[PDF] Top 20 Chronic graft-versus-host disease : a risk factor for secondary malignancies after allogeneic stem-cell transplant

... or chronic GVHD was exclusively based on the time of onset, with cGVHD occurring more than 100 days ...presents/persists after 100 days; besides the classic cGVHD there is the so-called overlap syndrome, ... See full document

... or chronic GVHD, and complained of muscle cramps or had clinical or electrodiagnostic signs of a peripheral nervous system disorder (Table 1, Table ...hematological malignancies were acute myeloid leukaemia ... See full document

... malignant disease itself GVHD is the most common cause of death for patients who have undergone stem cell transplantation ...[2]. Chronic GVHD can affect any organ system, especially skin, ... See full document

... for chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly chosen as salvage therapy for patients who are intolerant of IM, fail to achieve a ... See full document

... The finding that patients have few signs of psychological morbidity, such as stress and depression, despite the limitations imposed by chronic GvHD may be related to the care provided by the multidisciplinary team ... See full document

... - Graft versus-host disease (GVHD) is a potentially fatal immune-regulated injury occurring unpredictably in solid organ and bone marrow transplant ...limb transplant, determine ... See full document

... performed with the hydraulic hand dynamometer with the patient using the dominant hand, seated with the elbow bent at 90°, shoulder and forearm in neutral position, wrist slightly extended, with three measurements of the ... See full document

... oral chronic graft-versus-host disease, based on the histopathologic classification of the National Institutes of Health and correlate them with clinical ...of chronic ... See full document

... is graft-versus-host disease ...moderate-severe chronic GVHD ...against chronic GVHD (hazard ratio 0.23, p = 0.04). The 6-month transplant-related mortality, 1-year ... See full document

... The graft-versus-host disease (GVHD) is an immune-mediated syndrome expressed by cutaneous or cutaneous / systemic signals and symptoms, main- ly in recipients of allogeneic stem ... See full document

... overall survival do not appear to be affected by the incidence of CDI. These and other results suggest that while CDI is common after HSCT, it is rarely a life-threatening event. Over the last decade, heightened ... See full document

... xxx In this issue of the Revista Brasileira de Hematologica e Hemoterapia, Vigorito and colleagues describe the initial results of work by a group of Brazilian investigators to develop a platform for collaboration in ... See full document

... In four cases etanercept 25mg was administered twice a week with variable duration of treatment, achieving no response in 1 case (3 weeks), partial response in two 2 cases (4 weeks and 8 weeks) and a complete response in ... See full document

... All centres had high-resolution computed tomography and automated blood culture systems. Routine serum galacto- mannan testing was available only during the last 13 months of the study. The application of the test (as ... See full document

... The skin, gastrointestinal tract and liver are the main target organs affected in aGVHD. The first organ usually affected is the skin, in the form of a maculopapular rash in areas of the neck, ears, shoulders (cephalic ... See full document

... effects. Many late effects have a long latency period be- fore manifestation extending for many years after HCT. These data suggest the importance of regular surveillance for late effects among all survivors for ... See full document

... mesenchymal stem cells (4), or mesenchy- mal progenitor cells (MPC) ...adherent cell type evolving from bone marrow-derived low density mono- nuclear cells, cultured in a classical medium supplemented only ... See full document

... O mieloma múltiplo (MM) é uma neoplasia hematológica incurável com uma sobrevida mediana de três anos com a utilização de tratamento convencional. O transplante de células-tronco hematopoéticas alogênico (TCTH-alo) pode ... See full document

... crucial factor for Treg survival and growth [21,22] and can be utilized by Tregs more effectively than Tconvs because of their constitutive expression of the high affinity IL-2 receptor CD25/CD122/CD132 ...T ... See full document

... group, after adjusting for risk factors, correlated with higher female mortality, smoking, diabetes and peripheral arterial disease and/or carotid artery ... See full document