Top PDF Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.
Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.
... unchanged in the optic nerve and brain, and in fact, it attenuated in the spinal cord in Olig1 2/2 mice (Figure ...survival of this Olig1 2/2 mouse ...level ...
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EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE).
... area of inflammatory infiltrate was estimated by examining the area of staining for macrophages / activated microglia, the most numerous immune cell types present in MOG- EAE white matter ...Areas ...
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Baicalin reduces the severity of experimental autoimmune encephalomyelitis
... signs of disease up to 60 days after immunization. Mice were scored according to their clinical severity as follows: grade 0, no abnormality; grade ...loss of tail tonicity, assessed by inability to ...
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Ctla-4 modulates the differentiation of inducible Foxp3+ Treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis.
... Ac1–9 in CFA. In both scenarios, iTreg cells delayed disease progression (Figures 1A and 1B), demonstrating that iTreg cells mediate immune regulation independent of tTreg ...cells. In ...
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Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
... S2A,B). In inducible Sgpl1-deficient mice, analyzed two weeks after induction of gene deletion, S1P in the tissues was elevated to a lesser degree, ranging from 4-fold (heart) to ...
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Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by photobiomodulation induced by 670 nm light.
... ) of 670 nm (LED bandwidth 25–30 nm at Full Width Max Power [FWHM]) were obtained from Quantum Devices (Barneveld, ...Unanesthetized Mice were placed individually into a polypropyl- ene restraint device ...
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GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice
... activity of indoleamine 2,3-dioxygenase (IDO), which promotes tryptophan starvation due to its catabolism into ...kynurenine. In fact, it was al- ready demonstrated that IDO-expressing plasmacytoid ...
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Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
... one of the most important stress-inducible ...steps in the apoptosis pathway. In addition, Hsp70 is actively released into the extracellular milieu, thereby promoting innate and adaptive immune ...
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Chloroquine treatment enhances regulatory T cells and reduces the severity of experimental autoimmune encephalomyelitis.
... is of recent concern that regulatory T cells may turn into effector inflammatory ...cells in vivo and in vitro ...stimulation of the mTOR cascade, which induces the differentiation of ...
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Protoporphyrin Treatment Modulates Susceptibility to Experimental Autoimmune Encephalomyelitis in miR-155-Deficient Mice.
... migration of chronical-stimulated miR-155 -/- T cells, it did not improve the capacity of T cells to produce effector cytokines, such as IFN-γ ...[8]. In the adoptive transfer model, the percentage ...
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Kinin B(2) receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice
... role of the kinin system on leuko- cyte entry into the CNS in MS remains unclear, it has been shown that BK can interfere with the mechanism of leuko- cyte recruitment in various tissues ...
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Regulatory T cell induction during Plasmodium chabaudi infection modifies the clinical course of experimental autoimmune encephalomyelitis.
... Academy of Sciences for the Developing World (TWAS; Grant # 05-049 RG/BIO/LA), The National Institute for Vaccine Development and Technology (CNPq-INCTV) and Rede de Malaria ...role in the study design, ...
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Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.
... pathways of the host ...that in the absence of Ctsb, one or more of these key signaling pathways are no longer silenced by ...range of new questions regarding the involvement of ...
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Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.
... role of DNA repair in hematopoietic homeostasis has become increasingly clear in recent years ...models of many DNA repair enzymes are characterized by either reduced stem cell function or ...
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HVEM signalling promotes colitis.
... min. in PBS containing ...digested in complete IMDM medium containing 10% FCS and ...diluted in PBS with ...fixed in BD lysis buffer (BD Biosciences), permeabilized using ...antibodies ...
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Decreased production of TNF-alpha by lymph node cells indicates experimental autoimmune encephalomyelitis remission in Lewis rats
... disease of the central nervous system (CNS) characterised by demyelination, T cell and macrophage infiltration and a decrease in neurological function (Adams et ...1989). Experimental ...
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Rev. bras. farmacogn. vol.22 número3
... findings of the present study, therefore, tend to suggest that ...seizures of the mice used by enhancing, or in some ways interfering with GABAergic ...dose of 400 and 800 mg/kg ...
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Age-related retinopathy in NRF2-deficient mice.
... Microscopy Mice were terminally anesthetized and subjected to whole body perfusion with 4% paraformaldehyde in phosphate-buffered saline ...post-fixed in the same fixative overnight before embedded ...
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BCG and BCG/DNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis
... analysis of IFN- � and IL-10 levels, produced by peripheral lymphoid organs, answered some mechanistic ...tion in the brain. In this sense, the most interesting inding was the accentuated drop ...
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Increased autoimmune diabetes in pIgR-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
... congenic mice. Cd55 (Daf1) was also identified as a promising candidate gene in their study using B10-derived congenic intervals for Idd5 sub-loci ...[34]. In contrast, our B6-derived congenic ...
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