[PDF] Top 20 Drug-induced regulation of target expression.
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Drug-induced regulation of target expression.
... Many drug targets thought to be suitable for therapeutic purposes are subjected to positive or negative feedback loops upon chemical perturbations which might even account for the development of drug ... See full document
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Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations.
... mechanistic target of rapamycin (MTOR) pathway regulates cell growth, energy homeostasis, apoptosis, and immune ...protein of MTOR encoded by the RPTOR gene is a key component of this ... See full document
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POST-TRANSCRIPTIONAL REGULATION OF HFE GENE EXPRESSION
... levels of expression when compared to those obtained for an NMD-resistant HFE ...representation of the studied HFE minigenes designed to mimic human HFE genes that respectively encode normal (WT), ... See full document
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Subtractive libraries for prospecting differentially expressed genes in the soybean under water deficit
... Collections of cDNAs ex- pressed under stressed conditions have been a useful re- source to study gene expression and ...a target situation (Diatchenko et ...monitoring of citrus responses to ... See full document
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Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.
... functions of UA inhibit lipid peroxidation in a gentamicin- induced renal injury rat model, thus exerting an additional renal protective function ...inhibition of miRNA-21 expression in the ... See full document
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Retinoic acid signalling is activated in the postischemic heart and may influence remodelling.
... was induced through ligating the left coronary artery in ...activation of the RARs was measured by imaging RARE-luciferase reporter mice, and analysing expression of RAR target genes ... See full document
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Osteoblast-specific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts.
... member of the nuclear hormone receptor superfamily that regulates target gene transcription to ensure appropriate control of calcium homeostasis and bone ...lines of evidence that show that ... See full document
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Regulation of transgene expression in genetic immunization
... choice of promoter/enhancer to drive expression of the transferred ...upon target cell type as well as the func- tional goal of the ...production of many lym- phokines that can ... See full document
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Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation.
... ability of RvD1 to suppress development of ADR nephropathy can be attributed in large part to protecting against podocyte ...onset of heavy proteinuria coincided with a significant loss of ... See full document
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K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesis.
... effect of K13 on TPA-induced expression of RTA-target genes, we observed that it had no significant inhibitory effect on the induction of vIL6/K2 gene expression (Figure ... See full document
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Prediction of drug-target interactions and drug repositioning via network-based inference.
... activities of the compounds on ER, a yeast two-hybrid system was constructed by yeast co-transforma- tion with pGBKT7-ERa/bLBD and pGADT7-SRC1 according to the lithium acetate method ...301–553 of ERa and ... See full document
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The microRNAs in an ancient protist repress the variant-specific surface protein expression by targeting the entire coding sequence.
... length of 30 nts ...miRNA target site located completely within the 39 UTR. Instead, 39 UTR target sites usually straddle the stop codon with the miRNA seed sequence binding in the 3 9 UTR and the ... See full document
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MiR-142-3p attenuates the migration of CD4⁺ T cells through regulating actin cytoskeleton via RAC1 and ROCK2 in arteriosclerosis obliterans.
... analysis of the genes that are related to the regulation of actin cytoskeleton and have the miR-142-3p binding sites in their ...the regulation of actin cytoskeleton and cell ... See full document
10
Cytokine, antibody and proliferative cellular responses elicited by Taenia solium calreticulin upon experimental infection in hamsters.
... evidence of its role in immune regulation [10]. IL-10 expression induced by rTsCRT in local and systemic lym- phoid organs upon in vitro stimulation is in agreement with previous reports ... See full document
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Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation.
... through regulation of a series of downstream ...15% of all genes expression through binding on Figure 6. Inhibition of c-Myc suppresses proliferation and induces differentiation ... See full document
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ROD1 is a seedless target gene of hypoxia-induced miR-210.
... energy of -28.9 kcal/ mol (Fig.3B). The minimum free energy of miR-210/ROD1 interaction was comparable to those predicted for EFNA3 and ISCU, two well established miR-210 targets ...downstream of a ... See full document
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(Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1.
... the drug containing medium every 12 ...consisted of treatment with TSA, 5-aza- dC, TSA and 5-aza-dC, or culture medium ...concentrations of TSA and 5-aza-dC, which were previously empirically ... See full document
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Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.
... presence of mutations in the p53-dependent pathway ...effects of drug resistance caused by impaired p53 activation is to directly target downstream of p53, bypassing the need of ... See full document
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Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 –
... high expression in rat heart and is mainly located in the nuclei of H9c2 myogenic cells ...The expression pattern and nuclear localization suggest that Mipu1 plays a role in the regulation ... See full document
5
Transcriptional Regulation of Fibroblast Growth Factor 21 Expression
... FGF21 expression is induced by peroxisome proliferator-activated receptor α (PPARα) in the liver [15,16] and acts through endocrine mechanisms for adaptive starvation responses including gluconeogenesis, ... See full document
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