[PDF] Top 20 Drugging p53 in cancer: from yeast to human cells
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Drugging p53 in cancer: from yeast to human cells
... mut p53 is based on its role as a transcriptional factor. Thus, according to the effect of the amino acid substitution, p53 mutants can generally be classified into two main categories: ... See full document
102
Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy
... colorectal cancer cell lines (HCT116, HCT8, HT29, SW480) and fetal human colon (FHC) cell line were purchased from the American Type Culture Collection and cultured according to their ...used ... See full document
9
Cytotoxicity of Marchantia convoluta leaf extracts to human liver and lung cancer cells
... n-butanol) from a plant used in folk medicine, Marchantia convoluta, to human non-small cell lung carcinoma (H1299) and liver carcinoma (HepG2) cell lines was ...liver cancer cell ... See full document
8
Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells.
... collected from human STC1 transgenic male mice (line 2) [32] and wildtype males (2–4 months of age) of the same genetic background (C57Bl/6 x CBA) using heparin to prevent ...temperature to ... See full document
11
The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells.
... System in the presence of 1% phenylmethyl- sulfonyl fluoride (PMSF) solution, 1% sodium orthovanadate solution and 1% protease inhibitor cocktail ...jected to 12% sodium docecyl sulphate-polyacrylamide gel ... See full document
21
Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells.
... up to 3vh were analyzed by western blotting to detect the phosphorylation of ATM, H2AX (cH2AX), and Chk1, 3 key members of the DDR pathway [67] ...Compared to the levels in untreated HMECs, ... See full document
13
Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.
... transcript to generate mRNA and protein isoforms with structural and functional ...shown to be associated with malignant phenotypes of cancer cells, such as chemo-resistance and invasive ... See full document
13
Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells.
... concentrations in such diverse cell types as neuroblastoma, leukemia and hepatoma ...apoptosis in melanoma cells [29], these data further confirm that thiazole antibiotics may affect a wide variety ... See full document
7
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
... structures in response to ECM ...epithelial cells in hypoxia might be mediated by loss of histone deacetylation, ...of human breast epithelial cell organoids grown at 21% and 1% oxygen ... See full document
12
Sensitization of human pancreatic cancer cells harboring mutated K-ras to apoptosis.
... isoforms in the regulation of cell growth or death are rather controversial, depending upon different types of cells or cellular ...roles in the regulation of cancer development or programmed ... See full document
10
Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.
... apoptosis in hESCs Since rAAV infection has been previously regarded as non-toxic in many other cell types, it was important to delineate the mechanism by which rAAV induces ...involved in the ... See full document
13
Barnase as a new therapeutic agent triggering apoptosis in human cancer cells.
... barnase in the MTT assay proved to be selectively cytotoxic for cancer ...of cancer cells (except HL-60 cells) by more than 70% while it inhibited the survival of hPBMCs by only ... See full document
13
The redox state of cytochrome C modulates resistance to methotrexate in human MCF7 breast cancer cells
... MCF7 cells, either sensitive or MTX-resistant, were harvested from confluent dishes and total extracts were prepared according to ...transferred to PVDF membranes (Immobilon P, Millipore, ... See full document
12
To nick or not to nick: comparison of I-SceI single- and double-strand break-induced recombination in yeast and human cells.
... that, in order for a nick to stimulate gene targeting at a distant site, a replication fork must be present and collapse at the ...induced in a replicating plasmid or on the chromosome could also ... See full document
15
Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin.
... studies from our group have shown that the expression levels of Orc6 were highly elevated in colorectal cancer patient specimens and the induction of Orc6 was associated with 5-fluorouracil (5-FU) ... See full document
5
Evaluation of the role of LRP1B in the response of human ovarian cancer cells to liposomal doxorubicin
... derived from human ovarian tumours, were used: A2780 (ovarian endometroid adenocarcinoma), Ovcar-4 (high grade ovarian serous adenocarcinoma) and Ovcar-8 (high grade ovarian serous ...adenocarcinoma). ... See full document
76
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells
... lysed in Ripa buffer (Cell Signaling, #9808), containing protease inhibitors (Roche, ...concentration in total soluble protein extracts was deter- mined by using the Pierce coomassie plus assay reagent ... See full document
22
ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.
... of p53-mediated HR suppression on ATR The S15 site of p53 is modified by ATM and ATR kinases [34,44,45], and both kinases have been shown to promote HR in cells with impaired or lost ... See full document
10
Dipyridamole increases the cytotoxicity of cisplatin in human larynx cancer cells in vitro
... purchased from Sigma ...experiment in unsup- plemented medium to minimize the hydroly- sis of ...prepared in DMSO and kept in the dark at ... See full document
9
In situ identification of CD44+/CD24- cancer cells in primary human breast carcinomas.
... method to identify the CD44+/CD242 cancer cell population, we performed in parallel flow cytometric experiments and immunofluorescence analysis in 5 consecutive breast ...cancers. To ... See full document
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