[PDF] Top 20 Evolution of mutational robustness in an RNA virus.
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Evolution of mutational robustness in an RNA virus.
... research in /6 and other RNA ...changed in robustness relative to their common ancestor could help shed light on the genetic mechanism(s) underlying this difference in the /6-derived ... See full document
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Effects of ploidy and recombination on evolution of robustness in a model of the segment polarity network.
... result in very weak or absent interactions ...distribution of mutational ...variety of processes (RNA stabilities, protein stabilities, transfer/diffusion rates, ...the ... See full document
18
Global organization of a positive-strand RNA virus genome.
... goal of enhancing the accuracy of the structural ...correctness of the entire model from a functional standpoint will be challenging, due to its large size and the likelihood that some of its ... See full document
15
Adaptation to fluctuating temperatures in an RNA virus is driven by the most stringent selective pressure.
... population of an RNA virus, the bacteriophage Qb, at its optimal growth temperature (37uC) and at two new temperatures, one above the optimal value (43 uC) and another one below ...the ... See full document
11
Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native Activity.
... which an emerging new function trades off with the original function is a key characteristic of the dynamics of enzyme ...cases of laboratory evolution have unveiled a characteristic ... See full document
18
Experimental evolution of an RNA virus in wild birds: evidence for host-dependent impacts on population structure and competitive fitness.
... replicate in wild-caught American crows (Corvus brachyrhynchos), house sparrows (Passer domesticus), and American robins (Turdus migratorius), bypassing the mosquito portion of the arbovirus cycle in ... See full document
19
Variation in RNA virus mutation rates across host cells.
... size of the host type in the above model was ...decrease in insect ...performed in mammalian and insect ...similar in BHK-21, S2, Sf21, and C6/36 cells using a genetically engineered ... See full document
7
Ebolavirus Evolution: Past and Present.
... single-stranded RNA viruses. Depending on the virus and the variant involved, case fatality rates in outbreak settings can vary between 25% and ...member of the Filoviridae family, Marburg ... See full document
10
The ascent of the abundant: how mutational networks constrain evolution.
... abundances of the natural molecules (as estimated by their contiguity statistics) are even more statistically pronounced than their ...which of contiguity or thermostability better distinguishes naturally ... See full document
11
RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion.
... is an evolutionary mechanism of segmented RNA viruses that plays an impor- tant but ill-defined role in virus emergence and interspecies ...understanding of the cellular ... See full document
6
Mutational robustness of gene regulatory networks.
... genes. In addition, TF proteins often physically interact with each other and form protein dimers, which in combination with regulatory interactions gives rise to an intricate network of ... See full document
9
Assessment Of Some Acceleration Schemes In The Solution Of Systems Of Linear Equations.
... to an approximate solutions less than or equal to the dimension of the coefficient matrix for each identified systems of linear ...methods in terms of number of ...systems ... See full document
8
Functional specialization of the small interfering RNA pathway in response to virus infection.
... source of sense-antisense viral dsRNA from which vsiRNAs were ...from virus transcription or genome-antigenome intermedi- ates generated during ...types of replication intermediates, their transcrip- ... See full document
14
A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis.
... variety of genetic and/or epigenetic alterations result in a common phenotype required for cancer initiation and ...progression. In an effort to categorize the effects of specific ... See full document
15
Evolution of the division of labor between genes and enzymes in the RNA world.
... number of plus strands can be reduced through evolution even to 1 or 2 gene strands per protocell in cases when trade-off is strong between replication and enzymatic ...survival of plus ... See full document
9
Investigating The Use Of Mobile Computing In Zimbabwe Polytechnics Case Of A Polytechnic In Zimbabwe
... become an invaluable and inevitable part of teaching and learning in educational institutions ...used in Zimbabwe ...Polytechnics in Zimbabwe and specifically the Polytechnic understudy ... See full document
5
An application of reliability-based robustness assessment of steel moment
... Median lowest aftershock ground motion spectral acceleration at the fundamental period of the intact structure that leads to failure (solid line and left vertical axis) and median residu[r] ... See full document
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Nicotiana small RNA sequences support a host genome origin of cucumber mosaic virus satellite RNA.
... elements in the Nicotiana ...helper virus infection ...level in CMV- infected than uninfected ...function of the 2b silencing suppressor that can repress DNA methylation in plants ... See full document
13
Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma
... expression of MLH1 in patients harbouring BRAF V600E mutations, RET/PTC rearrangements and transitions (IDH1 and ...set of samples may provide a more detailed understanding of this ...issue. ... See full document
7
Mutational analysis of angiogenin gene in Parkinson's disease.
... total of 1498 study participants including 750 PD patients and 748 age/gender matched control subjects were included in this ...history of PD, 500 were sporadic late-onset PD and 200 were early-onset ... See full document
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