[PDF] Top 20 Genome-wide mapping of DNA strand breaks.
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Genome-wide mapping of DNA strand breaks.
... assess DNA damage include electrophoretic techniques such as pulse-field gel electrophoresis (PFGE)[1] or single-cell electrophoresis (Comet assay)[2] for a global assessment of DNA ...displaying ... See full document
10
Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae.
... most of the experiments described below, G1-synchronized diploid cells were plated and immediately irradiated with ...resulting DNA damage induces a crossover between the heterozygous SUP4-o gene and the ... See full document
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Optimization of Neutral Comet Assay for studying DNA double-strand breaks in pea and wheat
... A wide range of methods are presently used for detection of early biological effects of DNA-damaging agents in the environment, irrespective of whether they are toxic, mutagenic, ... See full document
7
Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis.
... role of DSB repair pathways during infection. A recA mutant of the ...cytotoxic DNA damage in the murine ...phenotype of BCG may have masked a recA deficiency cannot be ...attenuation ... See full document
8
Cohesin protects genes against γH2AX Induced by DNA double-strand breaks.
... absence of cohesin, leads to extended spreading farther away from the break unless some specific constraints counteract cH2AX ...nature of these potential constraints, we have compared our data with the ... See full document
17
Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase.
... a DNA sequence that is both necessary and sufficient for function; whereas, in most other eukaryotes, centromeres are maintained by poorly characterized epigenetic mechanisms in which DNA has a less ... See full document
10
Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas.
... specimens of leiomyoma and adjacent normal myome- trium were obtained from 10 Japanese women who had a single leiomyoma nodule to limit biological heterogeneity (Table ...size of leiomyoma ranged from 40 to ... See full document
13
Genome-wide association mapping of root traits in a japonica rice panel.
... linkage mapping studies conducted in smaller biparental populations detected many more QTLs per trait ...number of highly significant associations may be partly attributed to the fixation of some ... See full document
18
Genome-wide screen of DNA methylation changes induced by low dose X-ray radiation in mice.
... cause of chronic human diseases, including cancer [1]. Non- targeted effects of radiation contributed to mutagenesis and carcinogenesis are often grouped as bystander effects and radiation-induced genomic ... See full document
8
Genome-wide DNA methylation patterns and transcription analysis in sheep muscle.
... l of bisulfite treated DNA was amplified for 15–20 PCR cycles in four 100 m l reaction ...lane of an Illumina HiSeq sequencer using 100 bp paired-end reads (National Centre for Genome ... See full document
7
Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA.
... beginning of domestication, selected animals would freely breed among human settlements and would have had a flexible diet [12,13] resembling extensive pig production systems which still exist today ...mixture ... See full document
12
Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
... homologous DNA se- quence provided by the sister homologous chromatid to re- store a DSB ...binding of the MRN complex to the DSB ...‘ends of the DSB are digested by the exonuclease ac- tivity ... See full document
13
Association Study of an AFF1 Gene Polymorphism (rs340630) with Iranian Systemic Lupus Erythematosus Patients
... ml of the solution containing Taq DNA polymerase, stan- dard10x PCR buffer, 200 ng DNA, ...mM of each primer, 1.5mM of MgCl2 and 200 mM of dNTP mix and ...plified DNA ... See full document
6
Bayesian phylogeny analysis of vertebrate serpins illustrates evolutionary conservation of the intron and indels based six groups classification system from lampreys for ∼500 MY
... site of Bfl-spn-1 is preceded by the dipeptide motif Lys-Arg (KR), a distinct feature for substrates and inhibitors of proprotein convertases ...role of these serpins can be expected. Status ... See full document
25
Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort.
... Normality of the IL-6, IL-8, IL-10, IL-1ra and TNF-a quantitative phenotypes were assessed using descriptive statistics and distribution plots (histograms and q-q ...None of the cytokines were normally ... See full document
6
CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing.
... for genome-wide copy number is array comparative genomic hybridization (array CGH) [1, ...sequencing of genome partitions, such as the exome or a set of disease-relevant genes, is often ... See full document
18
Genome-wide association for mapping QTLs linked to protein and oil contents in soybean
... Association mapping detects and locates QTLs based on the correlation intensity between molecular markers and phenotypic ...both of the time (number of generations) passed since the recombination ... See full document
9
A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes.
... hypothesis of existence of longevity genes, another suggests that a lower frequency of risk alleles de- creases the incidence of age-related diseases in the long-lived ...role of ... See full document
12
A novel method for identification and quantification of consistently differentially methylated regions.
... Detection of regions displaying concordant methylation profiles in samples between probes is ideally suitable for high-density methylation data, such as data from tiling ...nature of the dependence ... See full document
11
Genome-wide DNA methylation profiling in cultured eutopic and ectopic endometrial stromal cells.
... expression of STAR and cyp19a1, which encode aromatase, the high SF-1 expression may have contributed to the high mRNA expression of STAR and cyp19a1 in the choESC and chocolate ...analysis of this ... See full document
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