[PDF] Top 20 Human factors required for mycobacterium tuberculosis macrophage infection
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Human factors required for mycobacterium tuberculosis macrophage infection
... M. tuberculosis can survive and even grow within macrophages, within phagosomes, a cellular compartment that provides camouflage from the immune system and limits the access and activity of some ...M. ... See full document
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Either non-homologous ends joining or homologous recombination is required to repair double-strand breaks in the genome of macrophage-internalized Mycobacterium tuberculosis.
... of infection, non- ingested Mtb were removed by extensive washing MØs three times with HBSS and after that the culture medium containing 1 mg/ml of gentamycin was added for 2 hours to kill extracellular bacteria, ... See full document
8
Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.
... during infection with modern strains is associated with a delayed inflammatory ...of macrophage cytokine responses to ancient versus modern strains at 24 h and 72 h post-infection from a single ... See full document
12
Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro.
... plasticity. Macrophage polarization during bacterial infection has been elucidated in numerous recent studies; however, macrophage polarization during tuberculous granulo- ma formation and ... See full document
16
Predicting and analyzing interactions between Mycobacterium tuberculosis and its human host.
... 85 human proteins and 53 Mtb ...The human proteins NFKB1 and CD74 are connected to 10 and 5 Mtb proteins, ...early infection, Mtb inhibits macrophage apoptosis by up- regulating the NF-kB ... See full document
12
Rv2190c, an NlpC/P60 family protein, is required for full virulence of Mycobacterium tuberculosis.
... be required for the invasion of macrophages ...was required for cell separation and cording, in addition to macrophage ...M. tuberculosis, limited work has been done with this family of ... See full document
8
Pathogenicity of Mycobacterium tuberculosis is expressed by regulating metabolic thresholds of the host macrophage.
... primary human PBMC-derived macrophages (HuMQ were infected with the indicated strains, and cultured either in complete RPMI (Utr), or in media supplemented with 5TG (10 ...of infection with the indicated ... See full document
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Differential MicroRNA Expression in Human Macrophages with Mycobacterium tuberculosis Infection of Beijing/W and Non-Beijing/W Strain Types.
... M. tuberculosis strain in south China, and it has caused large outbreaks of ...alters macrophage lysis and sub- sequent downstream immune response toward clearance of ... See full document
16
Manipulation of cysteine cathepsins during Mycobacterium tubersulosis infection of human macrophages
... the infection is generally capable of stopping the spread of the bacilli, containing them in histological structures called granulomas (Russell, ...latent infection, a situation where the person is infected ... See full document
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The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model.
... In this context, the preparation of the mycobacteria has much influence on the experimental observations: we and others found that mycobacteria bind to and activate macrophages to a much greater extent when sonicated ... See full document
13
glpx Gene in Mycobacterium tuberculosis Is Required for In Vitro Gluconeogenic Growth and In Vivo Survival.
... is required to achieve an initial instillation dose and also maintain high bacterial loads at later time points (acute and chronic ...post infection), however the rate of growth differs during the initial ... See full document
15
Identification and Manipulation of Cystatins to Control Mycobacterium tuberculosis Infection of Human Macrophages
... species Mycobacterium tuberculosis (Mtb), one of humankind’s most ancient and successful ...Mtb infection has been a problem over the ages, due to pathogen’s ability to survive in host cells and ... See full document
45
Proteases associated with mycobacterium tuberculosis infection
... M. tuberculosis is the ESX-1 type VII secretion ...virulence factors important for the pathogen replication in macrophages causing effects on host cells (Stanley et ...are required for their ... See full document
12
Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection
... tropical infection that affects millions of people in the ...cellular factors that play a role in T. cruzi infection have been uncovered, the molecular requirements for intracellular parasite growth ... See full document
13
Exogenous Re-infection by Multiple Exposures to <i>Mycobacterium tuberculosis</i> Contributes to Subsequent Development of Active Tuberculosis
... pulmonary tuberculosis in Western Europe with 47 new cases of active TB per hundred thousand inhabitants [5-7] ...of infection control practices [8-12] ... See full document
6
Immunologic evaluation and validation of methods using synthetic peptides derived from Mycobacterium tuberculosis for the diagnosis of tuberculosis infection
... This study was focused on the use of ESAT-6 and Ag85A synthetic peptides to improve the early diagnosis of patients infected with PTB and EPTB. Initial ELISA screens identified 13 peptides out of 22 that had accept- able ... See full document
9
High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography.
... and human population growth and travel ...of human tuberculosis (Figures 1 and 4D) ...major human MTBC lineages occur, and the deeply rooted lineages are present exclusively in West Africa ... See full document
14
Humoral response to HspX and GlcB to previous and recent infection by Mycobacterium tuberculosis
... Reference Center for infectious disease: Hospital de Doenças Tropicais (HDT). All hospital workers were invited to participate, 437 out of 540 HDT HCW were enrolled. Although, Goiania's TB incidence was 22/ 100,000 ... See full document
9
Mycobacterium Tuberculosis e a resistência do bacilo de Koch
... Bacterium tuberculosis, sendo que mais tarde, em 1886, Lehmann e Neumann alteraram o nome para Mycobacterium tuberculosis, presume-se que devido à sua semelhança com um fungo, tendo em conta a ... See full document
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Dormancy models for Mycobacterium tuberculosis: A minireview
... in human tuberculosis (Hu et ...drug-susceptible tuberculosis occurs in up to 5% of successfully treated patients and is thought to be the outcome when the dormant population is not sub- stantially ... See full document
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