[PDF] Top 20 Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
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Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.
... IETD-FMK that preferentially targets caspase-8, blocked cell death by only ...shows that the DEVD-FMK caspase-3 inhibitor blocked cell death by ...structure of CAAP. (A) SABLE ... See full document
14
Calcium and cell death signaling in neurodegeneration and aging
... shown that, in different tissues from senescent rats, there is an increase in Ca 2+ con- tent in the intracellular stores, such as the ER and mi- tochondria (Lopes et ...in apoptotic cell ... See full document
9
miR-24 regulates intrinsic apoptosis pathway in mouse cardiomyocytes.
... membrane, the initial step of mitochondrial-induced apoptosis, can be regulated by a variety of Bcl2 family ...them, the translocation of various Bcl2 family proteins from ... See full document
9
Identification of a novel Calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-κB pathway.
... enlargement of spleen, liver, abdominal glands, colic piles, worms and different inflammatory diseases ...evaluation of its wound healing potential [24]. The clinical and pathological effects ... See full document
14
Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration.
... range of biochemical proper- ties. Here, we investigated the anti-tumor effect of PMBPs on ovarian ...cancer. The results indicated that PMBPs significantly reduced the ... See full document
15
A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production
... in mitochondrial dysfunction and damage, as well as ROS production [13, ...14]. The Bcl-2 proteins are located within the outer mitochondrial membrane, the nuclear envelope and ... See full document
13
Arq. NeuroPsiquiatr. vol.75 número4
... One of the different genetic mechanisms involved in the carcinogenesis of meningiomas is influenced by interactions between proteins that induce and inhibit ...evaluate the ... See full document
7
Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway
... causes apoptosis (Fuchs & Steller, 2011; Kroemer, Galluzzi & Brenner, ...After mitochondrial membrane permeabilization induced by various apoptotic stimuli, Cyto c releases from ... See full document
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The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons.
... failure of arborization, and reduced synaptic ...accumulation of high concentrations of Phe in the brain ...documented that the final steps in caspase-dependent apoptosis ... See full document
7
MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H₂O₂)-induced apoptosis through targeting the mitochondria apoptotic pathway.
... more, the anti-apoptotic effect of miR-145 was neutralized when Bnip3, one of the predicted miR-145 targets, was over- ...over-expression of either Bnip3 CDS (containing ... See full document
9
Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.
... shown that decreasing myocardial G protein–coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial ...investigated the effect of ... See full document
10
Heparin modulates the expression of genes encoding pro and anti-apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats
... changes of the cell phenotype in response to IR injury 3,4 . Pro and anti-apoptotic proteins are involved in the cascade of IR injury 3,4 ...proposed that the use ... See full document
5
Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest.
... accumulation of free radical mediated damage may be a possible mechanism of cancer development ...oxidation of macromolecules and play an important role in mtDNA mutations, ageing, and cell death ... See full document
8
Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine proteases
... family of intracellular cysteine proteases with specificity for aspartic acid ...Two of these cysteine proteases, referred to as ‘‘initiator’’ and ‘‘effector’’ caspases, play important roles in the ... See full document
8
E. adenophorum Induces Cell Cycle and Apoptosis of Renal Cells through Mitochondrial Pathway and Caspase Activation in Saanen Goat.
... provinces of China. A rough estimate of the annual spreading rate of ...and anti-Inflammatory potential ...reported that the plant has neurotoxic and hepatotoxic effects ... See full document
16
Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
... activities. The ecological success of marine bivalves is based on the ability to modify their physiological functions in response to environmental ...One of the most important ... See full document
13
Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells.
... pathways that regulate cell processes, including cell proliferation, cell cycle progression and cell apoptosis, have significant impact on deciding cellular response to cis- ...shown that activation ... See full document
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Anticancer Effects of 1,3-Dihydroxy-2-Methylanthraquinone and the Ethyl Acetate Fraction of Hedyotis Diffusa Willd against HepG2 Carcinoma Cells Mediated via Apoptosis.
... reduction of MMP (Fig 4A) and increased intracellular ROS production (Fig 4B) were observed on DMQ and H-EtOAc fraction treated HepG2 cells in a dose and time dependent manner by flow ...to the con- ...to ... See full document
20
Yiwen Li, Yuqing Xu, Bo Lei, Wenxiu Wang, Xin Ge and Jingrui Li
... in the roots of a traditional Chinese herb, rhubarb, and has been shown to have some anticancer ...effects. The aim of the present study was to investigate the effect of ... See full document
9
Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
... patterns of Akt thus closely mirror the changes found in eNOS expression and phosphoryla- ...with the idea that the regulation Figure ...homogenates. Mitochondrial biogenesis ... See full document
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