[PDF] Top 20 Mechanism of action and membrane selectivity of a novel antimicrobial peptide
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Mechanism of action and membrane selectivity of a novel antimicrobial peptide
... – antimicrobial peptides) tem aumentado, principalmente devido ao facto destas moléculas possuirem um grande espetro de ação contra uma variedade de agentes patogénicos (incluindo bactérias, vírus, fungos e ... See full document
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Analogues of the antimicrobial peptide BP214
... Because of this feature, positively charged AMPs can interact with the surface of the negatively charged bacterial cell, leading to membrane modification and disruption and then, ... See full document
69
Fold-unfold transitions in the selectivity and mechanism of action of the N-terminal fragment of the bactericidal/permeability-increasing protein (rBPI21)
... as antimicrobial peptides, for instance, adopt a helical structure when interacting with lipid vesicles and not the other way ...flexibility and low chemical conformational stability probably imply ... See full document
10
Mechanisms of action and antimycobacterial activity of antimicrobial peptides
... the peptide associates with the lipids inducing vesicles destruction, forming lamellar structures with the peptide “sandwiched” between ...6C and 7C). The interaction was exothermic throughout. In ... See full document
191
Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides
... tors and α2-adrenoceptors in the heart, mainly in cardiac atria, appeared very ...site of atrial natri- uretic peptide (ANP) ...member of the natriuretic peptide family that also ... See full document
7
Mechanism of action of novel piperazine containing a toxicant against human liver cancer cells
... purpose of this study was to assess the cytotoxic potential of a novel piperazine derivative (PCC) against human liver cancer ...SNU-475 and 423 human liver cancer cell lines were used to ... See full document
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Differential scanning calorimetry of whole Escherichia coli treated with the antimicrobial peptide MSI-78 indicate a multi-hit mechanism with ribosomes as a novel target
... well-studied and clinically tested analogue of magainin-2 (Zasloff, 1987; Gottler & Ramamoorthy, ...residues and possesses a +9 net charge, due to the abundance of lysine residues, as well ... See full document
22
A novel immune evasion strategy of candida albicans: proteolytic cleavage of a salivary antimicrobial peptide.
... conditions of immune dysfunction, colonizing ...salivary antimicrobial peptides are considered to be an important part of the host innate defense system in the prevention of microbial ... See full document
9
Identification of a novel antimicrobial peptide from human hepatitis B virus core protein arginine-rich domain (ARD).
... rise of multidrug-resistant (MDR) pathogens causes an increasing challenge to public ...health. Antimicrobial peptides are considered a possible solution to this ...consists of 16 arginine residues ... See full document
15
Antimicrobial Action of the Essential Oil of Lippia gracilis Schauer
... efficiency of the oil of L. gracilis in the inhibition of the microorganisms assessed in this work agree Lippia performed by Pascual et ...oils of the species showed in their majority ... See full document
9
Effects of Dimerization on the Structure and Biological Activity of Antimicrobial Peptide Ctx-Ha
... One of the principal problems that restrict the use of cAMPs as antibiotics is their toxicity, which is because cAMPs target the cell ...eukaryotic and prokaryotic ...cellular selectivity ... See full document
8
Underlying mechanism of antimicrobial activity of chitosan microparticles and implications for the treatment of infectious diseases.
... emergence of antibiotic resistant microorganisms is a great public health concern and has triggered an urgent need to develop alternative ...alternative antimicrobial agent. However, the underlying ... See full document
10
Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens.
... phage-display peptide library panned against E. coli cells and a successive optimization phase for biological activity, synthesis and purification procedures ...amphipathic and cationic, which ... See full document
8
Design of embedded-hybrid antimicrobial peptides with enhanced cell selectivity and anti-biofilm activity.
... position of RI16, as shown in Table 1 and ...hybrid peptide could enhance antibacterial activity and inherit the anti-biofilm activity from ...C-terminus of all the peptides was ... See full document
13
Synergistic effects of the membrane actions of cecropin-melittin antimicrobial hybrid peptide BP100
... vitro and in vivo growth of economically important plant pathogenic ...fluorescence of BP100 was taken advantage of to study the peptide’s binding affinity and damaging effect on ... See full document
13
Side chain hydrophobicity modulates therapeutic activity and membrane selectivity of antimicrobial peptide mastoparan-X.
... acids and HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-tria- zolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethy- lamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N- methylmethanaminium ... See full document
9
Peptide:lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional studies
... effects of BP100 on GUVs of POPC or POPC:POPG (70:30 molar ratio) were examined using phase contrast optical ...absence of peptide were stable under the microscope and retained the ... See full document
15
Rapid cytotoxicity of antimicrobial peptide tempoprin-1CEa in breast cancer cells through membrane destruction and intracellular calcium mechanism.
... the membrane permeablizing effect of temporin- 1CEa on MDA-MB-231 and MCF-7 cells, calcein AM and ethidium homodimer (EthD-1) were ...intact membrane. EthD-1 is excluded by the intact ... See full document
12
U NRAVELLING NOVEL MODES OF ANTIMICROBIAL ACTION
... number of human infections that cause systemic diseases of mild to life-threatening ...incidence of methicillin-resistant ...States and Europe more deaths than the human immunodeficiency virus ... See full document
238
Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.
... inhibitor of translation initiation in vitro and in vivo ...members of the cyclopenta[b]benzofurans, cyclopent[bc]benzopyrans, and benzo[b]oxepines family for their potential to inhibit ... See full document
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