[PDF] Top 20 Metastatic colorectal cancer: treatment with panitumumab

... patients with metastatic colorectal cancer with EGFR expres- sion were randomized to receive panitumumab (6 mg/kg per IV infusion over 60 minutes every 2 weeks until disease ... See full document

... associated with the same disease phenotype tend to lie close to each other in a protein-protein interaction network ...that cancer signature genes are more likely to be close to known oncogenes and tumor ... See full document

... associated with response to fluoropyrimidine treatment in colorectal cancer patients remains controversial despite extensive ...254 colorectal cancer patients treated with ... See full document

... breast cancer cells with high proliferative activity, the concentration of the key enzyme TP is essentially higher than in other tissues, and even in tumors that are in chemotherapy- resistant areas ... See full document

... of panitumumab with fluorouracil, leucovorin, and irinotecan(FOLFIRI) compared with FOLFIRI alone as second- line treatment in patients with metastaticcolorectal ... See full document

... assessed with Pearson’s correlation ...(change<0%) with the highest sensitivity and specificity, the receiver operating characteristic (ROC) curves were cal- culated and the Youden’s index was used OS ... See full document

... Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide ...of metastatic CRC (mCRC). Standard of care for patients with mCRC who cannot undergo radical ... See full document

... patients with metastatic colorectal cancer treated with oxaliplatin (85 mg/m² on days 1 and 15 of each 28-day ...of treatment, using the NCI-CTC ... See full document

... 23% with FU/LV but has provided no meaningful survival ben- efit- median survival 11,0 months with FU alone versus 11,5 months with ...FU/FA treatment obtained in mCRC patients, other thera- ... See full document

... accordance with the ethical standards of the institutional and / or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical ...studies with ... See full document

... analyzed metastatic cancer patients from a single institution whose cancers had progressed after all available standard-of-care therapies and whose tumors underwent next-generation sequencing ...systemic ... See full document

... breast cancer disease and respective brain metastatic lesions ’ management reside in the need for devel- oping drugs that can recognize cancer cells and accumulate e fficiently ...The treatment ... See full document

... curative treatment for colorectal cancer is to detect asymptomatic recurrences with the premise that an important rate will be eligible for curative resection, improving overall ...patients ... See full document

... and metastatic cancers are still incurable despite the remarkable advances in translational and clinical research in the last ...patients with solid tumours in advanced ... See full document

... for treatment follow-up, prediction of recurrence or disease relapse and the sample collected for the prior purposes can be submitted to gene mutation detection, making ccfDNA a broad disease management ... See full document

... respectively, with a soft tissue penetration range of ...hours, with the remaining dose being taken up by the ...to metastatic bone pain from prostate ...partial, with different degrees of ... See full document

... breast cancer increased by 20% between 2008 and 2012, when ...common cancer in the world and the most common cancer among ...breast cancer increased in those four years by 14%, with a ... See full document

... on metastatic colorectal cancer and is combined with chemotherapeutic ...diagnosed with intestinal per- foration after bevacizumab treatment ten months after a metastatic ... See full document

... the treatment of metastatic colorectal cancer, amongst them the more efficient use of chemotherapy and the technological development, which has allowed for more complex liver surgery and less ... See full document

... patients with mCRC present with a deteriorated PS in clinical practice, the best treatment for these patients remains ...public cancer center had ECOG PS 3-4 at the time the first-line ... See full document