[PDF] Top 20 The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury

... After the chest was opened along the midline, the trunk of the pulmonary artery was separated, and a #1 suture was placed (without ...into the left ventricle, a transverse ... See full document

... photomicrograph of the lung tissues from group I and Figure 2 illustrates representative photomicrograph of the lung tissues from group II that obtained 24h after ... See full document

... Most of the knowledge gathered so far about the intracellular mechanisms of trimetazidine was obtained from animal models perfused with ...Because ischemia is associated with a ... See full document

... used in simi- lar experimental ...analogue of EPO, is a more useful agent due to its easier administration and its long-term ...studies in the contempo- rary literature regarding EPO, which ... See full document

... levels in naïve and IPC groups. The results indicated that in both groups there was a rise in serum IL-6 after 120 minutes of reperfusion, but it was significant higher in ... See full document

... used in our study. Rats were separated randomly into six groups consisting of seven rats as sham, torsion, torsion- detorsion, torsion- detorsion+saline, torsion-detorsion+resveretrol (20 mg/kg) and ... See full document

... hemorrhage in the I/R group at a statistically significant level but had no such effect on myofibrillar ...edema. The statistical significance of our study was increased by lowering ... See full document

... I/R. The molsidomine is a potent vasodilator that is widely used as antianginous, relaxing the smooth muscle by stimulating guanylate cyclase, increasing the levels of cyclic guanosine ... See full document

... apoptosis in periods of early reperfusion (4h) and late reperfusion ...those in the control group. Although the full mechanism involved was not explored, our results ... See full document

... transplantation model was induced according to methods previously described ...anesthesia, the abdomen was opened through an inverted T- incision, and the left diaphragmatic, hepatoesophageal ... See full document

... Due of the antioxidative properties of Dex, it seems possible that using Dex before ischemia/reperfusion may protect the testis tissue against oxidative I/R ...To the best ... See full document

... Thus the argument that bradykinin is a substrate of DPP- 4 is not entirely ...confirmed. In our study, we found that bradykinin was down-regulated with DPP-4 inhibitor treatment, and therefore ... See full document

... mediating the lung dysfunction that results from intestinal IRI ...role in asthma, not only in the induction of the Th2 immune response but also in amplifying and ... See full document

... product of degradation of protein metabolism and produced with the detoxification of toxic-effect ammonia, is a marker of renal function test ...Hence, the term BUN is ... See full document

... (SD). The normal distribution of the data was evaluated by Shapiro-Wilks ...met, the groups were compared by an analysis of variance (ANOVA) followed by Tukey’s multiple comparison ... See full document

... conclusion, the results from our experiments suggest that LD treatment may decrease cardi- ac infarct size and inhibit apoptosis, inflammation and oxidative ...with the activation of the AKT ... See full document

... investigated the protective effect of crocetin from Crocus sativus ...myocardial ischemia-reperfusion injury (MORO) in ...sham-operated, model, and low-, ... See full document

... protect the small intestine mucosa against an ischemic insult, according to different periods of ...Methods: The gut of 32 male rats was subjected to 60-min ischemia (clamping ... See full document

... investigate the gene expression related to inflammation on mice subjected to intestinal ischemia and reperfusion (I/R) and treated with ischemic preconditioning ...distributed in five groups ... See full document

... distributed in individual cages with water and rodent feed (Presence®) ad libitum and acclimatized in the laboratory for 7 ...handled in accordance with the precepts of ethics ... See full document