[PDF] Top 20 The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma

... immunity in MM. Tregs play an important role in the preservation of self-tolerance and modulation of overall immune responses against infections and tumor ... See full document

... fixed in 10% neutral buffered formalin, dehydrated, and embedded in ...Sections of 5 μm thickness were obtained for hematoxylin-eosin staining (H&E) and subsequent ex- amination by ... See full document

... a multiple ankyrin repeat containing protein, highly expressed in cancers, such as acute ...leukemia. The present study was undertaken to determine the expression and functional ... See full document

... use of other markers such as CTLA-4 and CD122, although also expressed under activation conditions, may aid in their ...characterization. In autoimmune disorders such as rheumatoid arthritis ... See full document

... occurrence of uncontrolled inflammatory responses in sarcoidosis suggests that the immunoregulatory process might be ...impaired. In our study, we found that the frequency of ... See full document

... investigate the hypothesis that osteoporosis is caused, at least in part, by elevated systemic sRANKL, experiments were performed using a mouse xenograft system in which the tumour ... See full document

... lower in patients who required therapy due to CLL during the follow-up period as compared to patients who were not treated, and correlated with the time from CLL diagnosis to the start ... See full document

... 7. Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation .Bone. 2007; 40: 251-264. 8. Del Fattore A, Teti A, Rucci N. Osteoclast receptors and signaling. Arch Biochem ... See full document

... that the primary MV infection of SSPE patients takes place predominantly below the age of two years, when the immune system of the host is still immature and ... See full document

... disease of the central nervous system (CNS), characterized by degradation of the myelin sheath and loss of oligodendrocytes, resulting in impaired nerve ...gression ... See full document

... populations of the adaptive immune system such as regulatory T cell subsets, T helper type 17 (Th17) and CD8 + cells are affected by gluten exposure in NOD ... See full document

... dysregulated in a number of solid tumors such as hepatocellular carcinoma, cholangiocellular carcinoma (15), and colorectal cancer ...(9). The present study extended this finding to MM ... See full document

... TLRs and NLR3 inflammasomes, acting in the induction and perpetuation of the inflammatory ...types of cells are involved in the innate immunity, such ... See full document

... [13]. The induction of Treg cells following UV irradiation is associated with UV-induced DNA ...Langerhans cells to move from the skin into the draining lymph nodes, and ... See full document

... present in developed and developing countries, but the most deaths occur in low-income ...prevalent in children and it is characterized by airway hyperresponsiveness (AHR), ... See full document

... Expression and function of Toll-like receptors (TLRs) in multiple myeloma (MM) has recently become the focus of several ...Knowledge of expression and ... See full document

... documented the capacity of Treg to control allergic diseases by down-regulating the priming of allergen-specific Th2- or Th1- type responses during the asymptomatic sensitization ... See full document

... multifactorial and chronic psychiatic ...cycles of mania and depression, with periods of remission or ...endocrine and immune systems in the pathophysiology of ... See full document

... stellate cells (HSCs), located in the space of Disse, are the cornerstone of liver fibrosis ...[15]. In response to inflammatory stimuli, quiescent HSCs usually activate ... See full document

... studies in non-obese diabetic (NOD) mice as well as Biobreeding (BB) rats have documented that the pathogenesis of type 1 diabetes (T1D) is influenced by diet ...onset in NOD mice: the ... See full document