[PDF] Top 20 Synthesis of novel α-santonin derivatives as potential cytotoxic agents
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Synthesis of novel α-santonin derivatives as potential cytotoxic agents
... high cytotoxic activity against several tumor lines tested, had been synthesized in our previous report with an overall yield of 5% [16] ...method of synthesis of this compound aiming ... See full document
7
Novel Penicillin Analogues as Potential Antimicrobial Agents; Design, Synthesis and Docking Studies.
... inoculums of these bacteria were pre- pared and diluted by sterilized normal ...turbidity of these cultures was adjusted by using ...mL of DMSO used as negative control in this ...concentration ... See full document
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Design, synthesis and biologival evaluation of novel isoniazid derivatives with potente antitubercular activity
... length of the substituent pro- motes the activity of these compounds is indeed ...activity of INH derivatives caused by an increase in the chain length of the substituent has already ... See full document
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Synthesis and evaluation of cytotoxic effects of Aminoester derivatives of natural α , β Amyrin mixture
... series of novel aminoacetyl α,β-amyrin derivatives were synthesized and their cytotoxic activities were evaluated against human colon carcinoma HCT-116, human acute promyelocytic ... See full document
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Synthesis of a new class of and evaluation of their potential as antitumoral agents
... A novel series of carbohydrate-based naphthoquinones was synthesized and evaluated for cytotoxicity against different cancer cell ...activity of these new naphthoquinone ...two derivatives were ... See full document
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Development of novel 4-azasteroid derivatives as potential 5a-reductase inhibitors Synthesis, biological and computational evaluation
... action of environmental agents that influence the acquisition of somatic genetic changes, and several other systemic or local factors including behavior/diet, hormones and growth factors resulting in ... See full document
148
Synthesis of Curcumin Derivatives As Potential P-Glycoprotein Inhibitors
... some novel curcumin derivatives 68-77 (Figure 14 and Scheme 12) were synthesized and their ability to inhibit tumor cell growth together with antiangiogenic activity was ...Most of the analogues ... See full document
145
Synthesis and biological evaluation of novel 6Hydroxybenzo[d]oxathiol2one Schiff bases as potential anticancer agents
... crystals of various derivatives 4 for single crystal structure ...crystals of 4q, grown from EtOH solution, were found to be of any ...one of the active compounds, see Table 1, the ... See full document
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Synthesis of 2,3Diyne1,4 derivatives and evaluation of cytotoxic activity against tumor cell lines
... series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling ...as ... See full document
7
Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents
... µL of another medium without the compound containing MTT ...µL of 20% SDS, and its absorbance was measured at 570 nm in a BioTek EL808 ...reader. Cytotoxic activity was quantified as the percentage ... See full document
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Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents
... 3-hydroxy-2-naphthoic acid (9.4 g, 0.050 mol), phloroglucinol (6.3 g, 0.050 mol) and freshly fused zinc chloride (20 g) was added phosphoryl chloride (50–60 mL). The reaction mixture was stirred at 70 °C for 2–3 h until ... See full document
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Synthesis of some novel pyrimidine, thiophene, coumarin, pyridine and pyrrole derivatives and their biological evaluation as analgesic, antipyretic and anti-inflammatory agents
... Handbook of Experimental ...reaction of β-amino-α,γ-dicyano -crotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial ... See full document
13
Synthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors
... because of their cardiovascular toxicity and their potential to increase the risk of ...classes of COX-2 Inhibitors. Materials and Methods: In this study, three novel analogues ... See full document
7
Synthesis and evaluation of novel pyrazole derivatives for cytotoxic activity
... review of the reported pyrazole derivatives regarding their cytotoxic ...pyrazole derivatives have well-known molecular targets, that are briefly ...The cytotoxic action of the ... See full document
119
Cytotoxic and inflammatory potential of a phospholipase A
... Platelet aggregation inhibitory assays were based on the turbidimetric method of Born [23], using platelet-rich plasma (PRP) and adenosine diphosphate (ADP) as agonist. PRP was obtained from blood collected by ... See full document
14
Mg(ClO 4) 2 catalyzed Eco-benign synthesis of 1,2,4-triazolinone derivatives as anti-tubercular agents
... green synthesis in organic transformations is increasing popularly day by ...eco-benign synthesis of 1,2,4-triazolinones incorporated with phthalimide and fluorenone functions using magnesium ... See full document
11
Synthesis of aryl b-N-acetylglucosaminedes modified at C-6 as potential antimicrovial agents.
... SYNTHESIS OF ARYL β-N-ACETYLGLUCOSAMINIDES MODIFIED AT C-6 AS POTENTIAL ANTIMICROBIAL ...the synthesis of aryl β-N-acetylglucosaminides containing azido, amino and acetamido groups at ... See full document
4
Synthesis and cytotoxic evaluation of new terpenylpurines
... terpenylpurine derivatives were efficiently prepared through alkylation of different purines with halogenated reagents derived from natural terpenoids, commercially available or isolated from their natural ... See full document
9
Synthesis, cytotoxicity and mechanistic evaluation of 4oxoquinoline3carboxamide derivatives : finding new potential Aaticancer drugs
... number of hydrogen bond donors (HBD) ≤ 5. Molecules violating more than one of these rules may show a low bioavailability ...profile of the derivative as a drug, showed 16b and 17b with the better ... See full document
20
Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential
... absence of the rigid spiroketal moiety (the analogs are classical aryl glycosides and therefore more flexible) is expected to impair the biological activity of the compounds, albeit not essential as we have ... See full document
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