[PDF] Top 20 Ubiquitin in the peroxisomal protein import pathway
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Ubiquitin in the peroxisomal protein import pathway
... between the monoubiquitination rates of PEX5 and a PEX5 protein possessing a cysteine-to-lysine substitution yielded negative results ...not the PIM was working at its maximum capacity in ... See full document
17
The pex5-mediated import pathway: characterization of the translocation step
... present in almost all eukaryotic cells. They were first described in 1954, by Rhodin, as microbodies (Rhodin, ...who, in 1966, defined them as a cellular compartment harboring at least one oxidase, ... See full document
140
The ubiquitin/proteasome pathway from Lemna minor subjected to heat shock
... decrease in the ubiquitin (Ub) monomer pool size and the accumulation of high molecular mass Ub-protein conjugates, possibly reflecting an increment in the supply of ... See full document
8
The proteasome-ubiquitin pathway in the Schistosoma mansoni egg has development- and morphology-specific characteristics
... packaged in a tanned protein shell, are produced by paired worms residing in the mesenteric veins of the human ...host. The vitelline cells are degraded as the larval ... See full document
8
Mouse Peroxisomal Protein cDNA Cloning and Characterization of its Intraclleular Localization
... Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxi- somal localization, and interaction with Pex1p-Pex6p ...Abnormality ... See full document
8
The first minutes in the life of a peroxisomal matrix protein
... events. The same conclusion is probably valid for monomer folding and monomer-PEX5 interaction because some active oligomeric peroxisomal proteins can be detected in the cytosol of cells ... See full document
26
Protein translocation across the peroxisomal membrane.
... on the PTS2 import pathway is still very ...of the WD-repeat protein fam- ily ...to the peroxisomal compartment. Indeed, in mammals this process requires Pex5L, ... See full document
18
Characterization of the mechanisms of protein translocation across the mammalian peroxisomal membrane
... all the advances made in recent years, there are still many aspects of this protein import pathway that remain ...regards the quaternary structure of the PEX5-cargo ... See full document
101
The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo
... PNS-based in vitro assay in the absence (lane 1) or presence (lane 2) of 10 µM ...PAGE/autoradiography. The autoradiograph (upper panel) and the corresponding Ponceau S-stained membrane ... See full document
40
The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.
... testicular protein extracts were prepared from postnatal day 20 testes by homogenization in lysis buffer (50 mM HEPES, ...with protein A agarose beads (Invitrogen) and centrifuged prior to use for IP ... See full document
7
Ubiquitin reference technique and its use in ubiquitin-lacking prokaryotes.
... of protein degradation by the N-end rule pathway ...by the proteasome [11,12,20–27]. The main determinant of an N-degron is a destabilizing N-terminal residue of a ...of the ... See full document
7
Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
... that the steady state level of one protein, FabD, is strongly regulated by pupylation while other confirmed (KasB, FabG4) and presumed (KasA) pupylated proteins in the same pathway are ... See full document
9
Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants.
... Rsp5p ubiquitin ligase, besides its well documented role in the entry of proteins into endocytic or MVB vesicles, also regulates the trafficking in the early secretory ... See full document
17
In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein
... found in human, mouse and rat genomes (GenBank AJ277365, AF525300, ...located in each C- terminal ...and the functional implications are dis- cussed. The model consists of 65 residues from ... See full document
7
Mapping of the cargo protein membrane translocation step into the PEX5 cycling pathway.
... associated protein complexes and protein folding or unfolding in an ATP-dependent manner ...includes the Walker A and B motifs for ATP binding and ATP hydrolysis respectively [234, ...domains ... See full document
86
Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein
... mechanism, the so-called cycling receptor model, are now numerous (18, 23, ...of the “details” of this pathway is still quite poor, leaving room for controver- sies between researchers in ... See full document
8
Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding.
... replicate in the cytoplasm and bud from the plasma ...is the major structural protein in paramyxoviruses that mediates viral assembly and ...Curiously, the matrix proteins ... See full document
17
A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway
... Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery 645. components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs 646[r] ... See full document
43
The peroxisomal protein import machinery displays a preference for monomeric substrates
... Interestingly, in a small number of cells (less than 5%), expression of ACOX1- Flag also resulted in a staining pattern that partially, but very weakly, overlapped with that of the peroxisomal ... See full document
13
The peroxisomal matrix protein import machinery - a PEX5 - centered perspective
... holdase-like protein. The data behind this concept comes from the finding that PEX5 binds monomers of human catalase (a tetrameric protein in its native state) and monomers of mouse ... See full document
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