Alho, A. M., Belo, S., Meireles, J., & Carvalho, M. M. D. (2012). Dirofilariose Canina e Felina, uma Parasitose em Evolução (I) – Etiologia, Biologia e Epidemiologia. Clinica Animal, 25, 20–25.
Alho, A. M., Landum, M., Ferreira, C., Meireles, J., Gonçalves, L., de Carvalho, L. M., & Belo, S. (2014). Prevalence and seasonal variations of canine dirofilariosis in
Portugal. Veterinary Parasitology, 206, 99–105.
https://doi.org/10.1016/j.vetpar.2014.08.014
Almeida, C. (2010). Prevalência da Dirofilariose Felina na região do Sado. Dissertação de Mestrado Integradoem Medicina Veterinária, FMV - UTL, Lisboa.
American Animal Hospital Association. (2009). Compliance : Taking Quality Care to the Next Level. (A. J. & C. Hardesty, Eds.). Lakewood, Colorado: American Animal Hospital Asssociation.
American Heartworm Society. (2014a). Current Feline Guidelines for the Prevention , Diagnosis , and Management of Heartworm (Dirofilaria immitis) Infection in cats. American Heartworm Society. Wilmington.
American Heartworm Society. (2014b). Orientações atuais para Prevenção, Diagnóstico e Controle da Dirofilariose (Dirofilaria immitis) em cães. American Heartworm Society. Wilmington.
Araujo, A. M. (1996). Canine and human Dirofilaria immitis infections in Portugal. A review. Parassitologia, 38, 366.
Atkins, C. (2017). Canine and Feline Heartworm Disease. In S. J. Ettinger, E. C. Feldman, & E. Côté (Eds.), Textbook of Veterinary Internal Medicine (8th editio, pp. 3166– 3227). St. Louis, Missouri: Elsevier.
Atkins, C. E., DeFrancesco, T. C., Coats, J. R., Sidley, J. A., & Keene, B. W. (2000). Heartworm infection in cats: 50 cases (1985-1997). Journal of the American
Veterinary Medical Association, 217, 355–358.
https://doi.org/10.2460/javma.2000.217.355
Barney, S., Blagburn, B. L., Brawner, W., Cattley, R., Dillon, A. R., Tillson, M., Welles, B., Johnson, C., Rynders, P. (2017). The progression of heartworm associated respiratory disease (HARD) in SPF cats 18 months after Dirofilaria immitis infection. Parasites and Vectors, 10, 225–235. https://doi.org/10.1186/s13071-017- 2425-9
Boon, J. A., Mihaylova, L., & Venco, L. (2014). Right Pulmonary Artery Distensibility Index (RPAD Index). A field study of an echocardiographic method to detect early development of pulmonary hypertension and its severity even in the absence of
63 regurgitant jets for Doppler evaluation in heartworm-infec. Veterinary Parasitology, 206, 60–66. https://doi.org/10.1016/j.vetpar.2014.08.016
Bowman, D. D., & Atkins, C. E. (2009). Heartworm Biology, Treatment, and Control. Veterinary Clinics of North America - Small Animal Practice, 39, 1127–1158. https://doi.org/10.1016/j.cvsm.2009.06.003
Byeon, K. H., Kim, B. J., Kim, S. M., Yu, H. S., Jeong, H. J., & Ock, M. S. (2007). A serological survey of Dirofilaria immitis infection in pet dogs of Busan, Korea, and effects of chemoprophylaxis. The Korean Journal of Parasitology, 45, 27–32. https://doi.org/10.3347/kjp.2007.45.1.27
Calvert, C. A., & Thomason, J. D. (2016). Heartworm disease. In M. A. Oyama, M. M. Sleeper, F. W. K. Smith Jr., & L. P. Tilley (Eds.), Manual of Canine and Feline Cardiology (5th Editio, pp. 188–197). St. Louis, Missouri: Elsevier. https://doi.org/10.1016/B978-1-56053-629-1.50009-1
Cancrini, G., & Gabrielli, S. (2007). Vectors of Dirofilaria nematodes: biology, behaviour and host/parasite relationships. In C. Genchi, L. Rinaldi, & G. Cringoli (Eds.), Mappe Parassitologiche (1st editio, pp. 48–58). Naples: Rolando Editore.
Cardoso, L., Mendão, C., & Madeira De Carvalho, L. (2012). Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal - A
national serological study. Parasites and Vectors, 5, 1–9.
https://doi.org/10.1186/1756-3305-5-62
Carretón, E. (2012). Dirofilariosis en Hurones y otros hospedadores. In J. A. Montoya- Alonso & E. Carretón (Eds.), Dirofilariosis Pautas de manejo clínico (1a edicion, pp. 159–168). Barcelona: Multimédica Ediciones Veterinárias.
Carretón, E., González-Miguel, J., Montoya-Alonso, J. A., Morchón, R., Simón, F., Passeri, B., Cantoni, A. M., Kramer, L. (2013). D-dimer deposits in lungs and kidneys suggest its use as a marker in the clinical workup of dogs with heartworm (dirofilaria immitis) disease. Veterinary Parasitology, 191, 182–186. https://doi.org/10.1016/j.vetpar.2012.08.008
Carretón, E., Morchón, R., & Montoya-Alonso, J. A. (2012). Dirofilariosis Cardiopulmonar Canina. In J. A. Montoya-Alonso & E. Carretón (Eds.), Dirofilariosis Pautas de manejo clínico (1a edicion, pp. 1–130). Barcelona: Multimédica Ediciones Veterinárias.
Carretón, E., Morchón, R., & Montoya-Alonso, J. A. (2017). Cardiopulmonary and inflammatory biomarkers in heartworm disease. Parasites and Vectors, 10, 151– 163. https://doi.org/10.1186/s13071-017-2448-2
Carretón, E., Morchón, R., Simón, F., Juste, M. C., Méndez, J. C., & Montoya-Alonso, J. A. (2014). Cardiopulmonary and inflammatory biomarkers in the assessment of the
64 severity of canine dirofilariosis. Veterinary Parasitology, 206, 43–47. https://doi.org/10.1016/j.vetpar.2014.08.019
Dantas-Torres, F., & Otranto, D. (2013). Dirofilariosis in the Americas: A more virulent Dirofilaria immitis? Parasites and Vectors, 6, 1–9. https://doi.org/10.1186/1756- 3305-6-288
Dillon, A. R., Blagburn, B. L., Tillson, M., Brawner, W., Welles, B., Johnson, C., Cattley, R., Rynders, P., Barney, S. (2017). Heartworm-associated respiratory disease (HARD) induced by immature adult Dirofilaria immitis in cats. Parasites and Vectors, 10, 209–224. https://doi.org/10.1186/s13071-017-2452-6
Ferreira, C. A. C., De Pinho Mixão, V., Novo, M. T. L. M., Calado, M. M. P., Gonçalves, L. A. P., Belo, S. M. D., & De Almeida, A. P. G. (2015). First molecular identification of mosquito vectors of Dirofilaria immitis in continental Portugal. Parasites and Vectors, 8, 1–11. https://doi.org/10.1186/s13071-015-0760-2
Forum Estudante. (2005). Guias Univ - Braga + Guimarães. (P. Morais, Ed.) (1a ed.). Lisboa: Palmigráfica - Artes Gráficas, Lda.
Genchi, C., Guerrero, J., McCall, W., & Venco, L. (2007a). Epidemiology and prevention of Dirofilaria infections in dogs and cats. In C. Genchi, L. Rinaldi, & G. Cringoli (Eds.), Mappe parassitologiche (1st editio, pp. 147–161). Naples: Rolando Editore. Genchi, C., Rinaldi, L., Cascone, C., Mortarino, M., & Cringoli, G. (2005). Is heartworm disease really spreading in Europe? Veterinary Parasitology, 133, 137–148. https://doi.org/10.1016/j.vetpar.2005.04.009
Genchi, C., Rinaldi, L., Mortarino, M., Genchi, M., & Cringoli, G. (2009). Climate and Dirofilaria infection in Europe. Veterinary Parasitology, 163, 286–292. https://doi.org/10.1016/j.vetpar.2009.03.026
Genchi, C., Venco, L., & Genchi, M. (2007b). Guidelines for the laboratory diagnosis of canine and feline Dirofilaria infections. In C. Genchi, L. Rinaldi, & G. Cringoli (Eds.), Mappe Parassitologiche (1st editio, pp. 138–144). Naples: Rolando Editore. Governo Civil do Distrito de Braga. (1985). O distrito de Braga - Imagem real e potencialidades. (Governo Civil do Distrito de Braga, Ed.). Vila Nova de Famalicão: Centro Gráfico.
Harrus, S., & Baneth, G. (2005). Drivers for the emergence and re-emergence of vector- borne protozoal and bacterial diseases. International Journal for Parasitology, 35(11–12), 1309–1318. https://doi.org/10.1016/j.ijpara.2005.06.005
Hoch, H., & Strickland, K. (2008). Canine and feline dirofilariasis: Life Cycle, Pathophysiology, and Diagnosis. Compendium on Continuing Education for the Practicing Veterinarian, 30, 133–140.
65 Instituto Nacional de Estatística. (2012). Censos 2011 Resultados Definitivos - Região Norte. (Instituto Nacional de Estatistica, Ed.). Lisboa: Instituto Nacional de Estatistica, I.P. https://doi.org/ISBN 978-989-25-0148-2
Kramer, L. H. (2007). Immunopathogenesis of filarial infetions in dogs and cats: a role for Wolbachia endosymbiont? In C. Genchi, L. Rinaldi, & G. Cringoli (Eds.), Mappe Parassitologiche (1st editio, pp. 68–72). Naples: Rolando Editore.
Labarthe, N. V., Paiva, J. P., Reifur, L., Mendes-De-Almeida, F., Merlo, A., Pinto, C. J. C., Juliani, P. S., De Almeida, M. A. O., Alves, L. C. (2014). Updated canine infection rates for Dirofilaria immitis in areas of Brazil previously identified as having a high incidence of heartworm-infected dogs. Parasites and Vectors, 7, 1–8. https://doi.org/10.1186/s13071-014-0493-7
Landum, M., Ferreira, C. C., Calado, M., Alho, A. M., Maurício, I. L., Meireles, J. S., De Carvalho, L. M., Cunha, C., Belo, S. (2014). Detection of Wolbachia in Dirofilaria infected dogs in Portugal. Veterinary Parasitology, 204, 407–410. https://doi.org/10.1016/j.vetpar.2014.05.027
Lee, A. C. Y., & Atkins, C. E. (2010). Understanding Feline Heartworm Infection: Disease, Diagnosis, and Treatment. Topics in Companion Animal Medicine, 25, 224–230. https://doi.org/10.1053/j.tcam.2010.09.003
Lu, T., Wong, J. Y., Tan, T. L., & Hung, Y. W. (2017). Prevalence and epidemiology of canine and feline heartworm infection in Taiwan. Parasites and Vectors, 10, 7–15. https://doi.org/10.1186/s13071-017-2435-7
Maureen, C. G., & Nolan, T. J. (2011). Factors influencing heartworm, flea, and tick preventative use in patients presenting to a veterinary teaching hospital. Preventive
Veterinary Medicine, 93, 1–16.
https://doi.org/10.1016/j.prevetmed.2009.10.012.Factors
McCall, J. W. (2005). The safety-net story about macrocyclic lactone heartworm preventives: A review, an update, and recommendations. Veterinary Parasitology, 133, 197–206. https://doi.org/10.1016/j.vetpar.2005.04.005
McHaffie, J. (2012). Dirofilaria immitis and Wolbachia pipientis: A thorough investigation of the symbiosis responsible for canine heartworm disease. Parasitology Research, 110, 499–502. https://doi.org/10.1007/s00436-011-2644-5 Meireles, J., Paulos, F., & Serrão, I. (2014). Dirofilariose canina e felina. Revista
Portuguesa de Ciências Veterinárias, 109, 70–78.
Méndez, J. C., Carretón, E., Martínez-Subiela, S., Tvarijonaviciute, A., Cerón, J. J., & Montoya-Alonso, J. A. (2015). Acute phase protein response in heartworm-infected dogs after adulticide treatment. Veterinary Parasitology, 209, 197–201. https://doi.org/10.1016/j.vetpar.2015.02.036
66 Méndez, J. C., Carretón, E., & Montoya-Alonso, J. A. (2012). Dirofilariosis Cardiopulmonar Felina. In J. A. Montoya-Alonso & E. Carretón (Eds.), Dirofilariosis Pautas de manejo clínico (1a edicion, pp. 131–158). Barcelona: Multimédica Ediciones Veterinárias.
Montoya-Alonso, J. A., Carretón, E., Corbera, J. A., Juste, M. C., Mellado, I., Morchón, R., & Simón, F. (2011). Current prevalence of Dirofilaria immitis in dogs, cats and humans from the island of Gran Canaria, Spain. Veterinary Parasitology, 176, 291– 294. https://doi.org/10.1016/j.vetpar.2011.01.011
Montoya-Alonso, J. A., Carretón, E., Morchón, R., Silveira-Viera, L., Falcón, Y., & Simón, F. (2016). The impact of the climate on the epidemiology of Dirofilaria immitis in the pet population of the Canary Islands. Veterinary Parasitology, 216, 66–71. https://doi.org/10.1016/j.vetpar.2015.12.005
Montoya-Alonso, J. A., Morchón, R., Falcón-Cordón, Y., Falcón-Cordón, S., Simón, F., & Carretón, E. (2017). Prevalence of heartworm in dogs and cats of Madrid, Spain. Parasites and Vectors, 10, 1–6. https://doi.org/10.1186/s13071-017-2299-x
Montoya, J. A., Morales, M., Juste, M. C., & Corbera, J. A. (2007). Heartworm (Dirofilaria immitis) infection in dogs: current update in Spain. In C. Genchi, L. Rinaldi, & G. Cringoli (Eds.), Mappe Parassitologiche (1st editio, pp. 177–180). Naples: Rolando Editore.
Morchón, R., Carretón, E., González-Miguel, J., & Mellado-Hernández, I. (2012). Heartworm disease (dirofilaria immitis) and their vectors in Europe - new
distribution trends. Frontiers in Physiology, 3, 1–11.
https://doi.org/10.3389/fphys.2012.00196
Morchón, R., Ferreira, A. C., Martín-Pacho, J. R., Montoya, A., Mortarino, M., Genchi, C., & Simón, F. (2004). Specific IgG antibody response against antigens of Dirofilaria immitis and its Wolbachia endosymbiont bacterium in cats with natural and experimental infections. Veterinary Parasitology, 125(3–4), 313–321. https://doi.org/10.1016/j.vetpar.2004.08.003
Nelson, C. T. (2008). Dirofilaria immitis in Cats: Anatomy of a Disease. Compendium on Continuing Education for the Practicing Veterinarian, 30(7), 382–389.
Otranto, D., Dantas-Torres, F., Brianti, E., Traversa, D., Petrić, D., Genchi, C., & Capelli, G. (2013). Vector-borne helminths of dogs and humans in Europe. Parasites and Vectors, 6, 1–14. https://doi.org/10.1186/1756-3305-6-16
Ramos, C., Martins, A., Coimbra, M., de Sousa, B., Cristóvão, J., Cortes, S., Campino, I., Maia, C. (2012). A importância da Leishmaniose e Dirofilariose felinas no concelho de Olhão. In XVI Congresso Português de Parasitologia, 29 - 30 Novembro. Lisboa, Portugal.
67 Metropolitana de Lisboa. Dissertação de Mestrado Integrado em Medicina Veterinária, FMV - UTL, Lisboa.
Simón, F., Morchón, R., González-Miguel, J., Marcos-Atxutegi, C., & Siles-Lucas, M. (2009). What is new about animal and human dirofilariosis? Trends in Parasitology, 25(9), 404–409. https://doi.org/10.1016/j.pt.2009.06.003
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012). Human and animal dirofilariasis: The emergence of a zoonotic mosaic. Clinical Microbiology Reviews, 25, 507–544. https://doi.org/10.1128/CMR.00012-12
Strickland, K. N. (1998). Canine and feline caval syndrome. Clinical Techniques in Small Animal Practice, 13, 88–95. https://doi.org/10.1016/S1096-2867(98)80012-1 Traversa, D., Di Cesare, A., & Conboy, G. (2010). Canine and feline cardiopulmonary
parasitic nematodes in Europe: Emerging and underestimated. Parasites and Vectors, 3, 1–22. https://doi.org/10.1186/1756-3305-3-62
Venco, L., Genchi, C., Genchi, M., Grandi, G., & Kramer, L. H. (2008). Clinical evolution and radiographic findings of feline heartworm infection in asymptomatic
cats. Veterinary Parasitology, 158, 232–237.
https://doi.org/10.1016/j.vetpar.2008.09.011
Venco, L., Manzocchi, S., Genchi, M., & Kramer, L. H. (2017). Heat treatment and false- positive heartworm antigen testing in ex vivo parasites and dogs naturally infected by Dirofilaria repens and Angiostrongylus vasorum. Parasites and Vectors, 10, 129– 134. https://doi.org/10.1186/s13071-017-2444-6
Vieira, L., Silvestre-Ferreira, A. C., Fontes-Sousa, A. P., Balreira, A. C., Morchón, R., Carretón, E., Vilhena, H., Simón, F., Montoya-Alonso, J. A. (2015). Seroprevalence of heartworm (Dirofilaria immitis) in feline and canine hosts from central and
northern Portugal. Journal of Helminthology, 89, 625–629.
https://doi.org/10.1017/S0022149X14000352
Voller, A., Bartlett, A., & Bidwell, D. E. (1978). Enzyme immunoassays with special reference to ELISA techniques. Journal of Clinical Pathology, 31, 507–520. https://doi.org/10.1136/jcp.31.6.507
Ware, W. A. (2010). Filariosis. In C. G. Couto & R. W. Nelson (Eds.), Medicina Interna de Pequeños Animales (Cuarta edi, pp. 169–182). Barcelona: Elsevier.
Wolstenholme, A. J., Evans, C. C., Jimenez, P. D., & Moorhead, A. R. (2015). The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria
immitis. Parasitology, 142, 1249–1259.
xxvii
xxviii ANEXO I – Questionário aos tutores
xxix ANEXO II – Declaração de consentimento informado
xxx ANEXO III – Folha de explicação do processamento das amostras