• Os resultados da expressão da proteína HIF-1α ao longo do desenvolvimento do CXAP indicam que não há diferença da resposta hipóxica nos diferentes grupos estudados.
• Os resultados da imunoistoquímica sugerem que a proteína GLUT-1 esteja associada com a transformação maligna do AP enquanto a expressão das proteínas FASN e adipofilina aumente para suportar a proliferação das células tumorais.
CORRELAÇÃO ENTRE A EXPRESSÃO GÊNICA E IMUNOISTOQUÍMICA
• A ausência de diferença na expressão gênica e imunoistoquímica de HIF-1α entre as amostras estudadas reforça que tanto o AP quanto o CXAP são tumores com bom estado de oxigenação.
• O aumento na expressão gênica e imunoistoquímica de GLUT-1 confirma nossa hipótese de que a captação de glicose e a expressão de seus transportadores em células transformadas é importante para o desenvolvimento do CXAP.
• O aumento na expressão das proteínas FASN e adipofilina ao longo da carcinogênese do AP e a ausência da expressão da proteína GLUT-1 no AP pode refletir o papel dos controles regulatórios transcricionais e pós-traducionais que atuam na expressão destes genes.
REFERÊNCIAS*
Abdelrahman AE, Rashed HE, Elkady E, Elsebai EA, El-Azony A, Matar I. Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer. Ann Diagn Pathol. 2019 Apr; 39:42-52.
Abraham S, Hu N, Jensen R. Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system. J Neurooncol. 2012; 108:459–468.
Abu-Ghanem Y, Mizrachi A, Popovtzer A, Abu-Ghanem N, Feinmesser R. Recurrent pleomorphic adenoma of the parotid gland: institutional experience and review of the literature. J Surg Oncol. 2016 114(6):714–8.
Agostini M, Silva SD, Zecchin KG, Coletta RD, Jorge J, Loda M, Graner E. Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells. Oral Oncol. 2004 Aug;40(7):728-35.
Alo PL, Amini M, Piro F, Pizzuti L, Sebastiani V, Botti C, Murari R, Zotti G, Di Tondo U. Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. Anticancer Res. 2007 Jul-Aug;27(4B):2523-7.
Altemani A, Martins M, Freitas L, Soares F, Araújo N, Araújo V. Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology 2005 46(6):635–641
Ambrosio MR, Piccaluga PP, Ponzoni M, Rocca BJ, Malagnino V, Onorati M, De Falco G, Calbi V, Ogwang M, Naresh KN, et al. The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: Adipophilin. PLoS One. 2012;7:e44315.
Andreasen S, Therkildsen MH, Bjorndal K, Homoe P. Pleomorphic adenoma of the parotid gland 1985-2010: a Danish nationwide study of incidence, recurrence rate, and malignant transformation. Head Neck 2016 38(Suppl 1):E1364–9.
Antony J, Gopalan V, Smith RA, Lam AK. Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. Head Neck Pathol. 2012 Mar;6(1):1-9.
Aquino-Galvez A, Gonzalez-Avila G, Delgado-Tello J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016; 35:577–583.
Asahina M, Saito T, Hayashi T, Fukumura Y, Mitani K, Yao T. Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features. Histopathology. 2019 Feb;74(3):514-525.
_______________________________________
*De acordo com as normas da UNICAMP/FOP, baseadas na padronização do International Committee of Medical Journal Editors – Vancouver Group. Abreviatura dos periódicos em conformidade com o PubMed.
Bandyopadhyay S, Pai SK, Watabe M, Gross SC, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Markwell SJ, Wang Y, Huggenvik J, Pauza ME, Iiizumi M, Watabe K. FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene. 2005 Aug 11;24(34):5389-95.
Baredes S, Ludwin DB, Troublefield YL, Langer PD, Mirani N. Adenocarcinoma ex- pleomorphic adenoma of the lacrimal sac and nasolacrimal duct: a case report. Laryngoscope. 2003 Jun;113(6):940-2.
Barron CC, Bilan PJ, Tsakiridis T, Tsiani E. Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment. Metabolism. 2016 Feb;65(2):124-39.
Barsky SH. Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotype. Exp Mol Pathol. 2003 Apr;74(2):113-22.
Barthel A, Okino ST, Liao J, Nakatani K, Li J, Whitlock JP Jr, Roth RA. Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J Biol Chem. 1999 Jul 16;274(29):20281-6.
Batsakis JG, Kraemer B, Sciubba JJ. The pathology of head and neck tumors: The myoepithelial cell and its participation in salivary gland neoplasia, Part 17. Head Neck Surg 1983; 5:222-33. Batsakis JG, Regezi JA. The pathology of head and neck tumors: salivary glands, part 4. Head Neck Surg. 1979 Mar-Apr;1(4):340-9.
Bauerschlag DO, Maass N, Leonhardt P, Verburg FA, Pecks U, Zeppernick F, Morgenroth A, Mottaghy FM, Tolba R, Meinhold-Heerlein I, Bräutigam K. Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer. J Transl Med. 2015 May 7;13:146.
Bell D, Bullerdiek J, Gnepp DR, Schwartz MR, Stenman G, Triantafyliou A. Pleomorphic Adenoma. In: El-Naggar AK, Chan JK, Grandis Jennifer R, Takata T, Slootweg PJ, organizadores. WHO Classif Head Neck Tumours. Fourth. 2017;185-186.
Bellizzi AM, Mills SE. Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature. Am J Clin Pathol. 2008 Sep;130(3):355-62.
Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJO, Karpe F, Schulze A, Harris AL. Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia- reoxygenation. Cell Rep. 2014 Oct 9;9(1):349-365.
Bickel PE, Tansey JT, Welte MA. PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta. 2009 Jun;1791(6):419-40.
Boussahmain C, Mochel MC, Hoang MP. Perilipin and adipophilin expression in sebaceous carcinoma and mimics. Hum Pathol. 2013 Sep;44(9):1811-6.
Bowman J, Daudia A, Sahasrabudhe N, Belloso A. Coblator-Assisted Endoscopic Transnasal Resection of a Large Nasopharyngeal Pleomorphic Adenoma. Case Rep Otolaryngol. 2019 Feb 27; 2019:4654357.
Bozza PT, Viola JP. Lipid droplets in inflammation and cancer. Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):243-50.
Branco DC, da Costa NMM, Abe CTS, Kataoka MSDS, Pinheiro JJV, Alves Júnior SM. HIF- 1α, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Jan;127(1):e8-e17.
Brand, RA. Biographical sketch: Otto Heinrich Warburg, PhD, MD. Clin. Orthop. Relat. Res., 468 (2010):2831-2832.
Brasaemle DL. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res. 2007 Dec;48(12):2547-59.
Burns JS, Manda G. Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance. Int J Mol Sci. 2017 Dec 19;18(12).
Campbell WG Jr, Priest RE, Weathers DR. Characterization of two types of crystalloids in pleomorphic adenomas of minor salivary glands. A light-microscopic, electron-microscopic, and histochemical study. Am J Pathol. 1985 Feb;118(2):194-202.
Cantuaria G, Fagotti A, Ferrandina G, Magalhaes A, Nadji M, Angioli R, Penalver M, Mancuso S, Scambia G. GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy. Cancer. 2001 Sep 1;92(5):1144-50.
Cao Q, Ruan H, Wang K, Song Z, Bao L, Xu T, Xiao H, Wang C, Cheng G, Tong J, Meng X, Liu D, Yang H, Chen K, Zhang X. Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma. Int J Oncol. 2018 Jul;53(1):137- 147.
Cardone RA, Casavola V, Reshkin SJ. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer. 2005 Oct;5(10):786-95.
Cardoso CM, de Jesus SF, de Souza MG, Santos EM, Santos CKC, Silveira CM, Santos SHS, de Paula AMB, Farias LC, Guimarães ALS. Is HIF1-a deregulated in malignant salivary neoplasms? Gene. 2019 Jun 15; 701:41-45.
Carlson ER, Schlieve T. Salivary Gland Malignancies. Oral Maxillofac Surg Clin North Am. 2019 Feb;31(1):125-144.
Chatterjee T, Panda PK. A Pathological Study Of Benign And Malignant Tumours Of Salivary Glands. Med J Armed Forces India. 2000 Oct;56(4):282-286.
Chen J, Cao L, Li Z, Li Y. SIRT1 promotes GLUT1 expression and bladder cancer progression via regulation of glucose uptake. Hum Cell. 2019 Apr;32(2):193-201.
Chen X, Lu P, Zhou S, Zhang L, Zhao JH, Tang JH. Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis. Oncotarget. 2017 Feb 21;8(8):13206-13213.
Chen ZP, McConell GK, Michell BJ, Snow RJ, Canny BJ, Kemp BE. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1202-6.
Chen Y, Lu Y, Lu C, et al. Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1α expression. Pathol Oncol Res. 2009;15:487–493.
Cheng C, Geng F, Cheng X, Guo D. Lipid metabolism reprogramming and its potential targets in cancer. Cancer Commun (Lond). 2018 May 21;38(1):27.
Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci USA. 2003 May 27;100(11):6358- 63.
Cho KJ, El-Naggar AK, Mahanupab P, Luna MA, Batsakis JG. Carcinoma ex-pleomorphic adenoma of the nasal cavity: a report of two cases. J Laryngol Otol. 1995 Jul;109(7):677-9. Chong BM, Reigan P, Mayle-Combs KD, Orlicky DJ, McManaman JL. Determinants of adipophilin function in milk lipid formation and secretion. Trends Endocrinol Metab. 2011; 22:211–217.
Chooback N, Shen Y, Jones M, Kasaian K, Martin M, Ng T, Thomson T, Marra M, Laskin J, Ho C. Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy. Curr Oncol. 2017 Jun;24(3):e251-e254.
Coller HA. Is cancer a metabolic disease? Am J Pathol. 2014 Jan;184(1):4-17.
Conte M, Franceschi C, Sandri M, Salvioli S. Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective. Trends Endocrinol Metab. 2016 Dec;27(12):893-903.
Cori CF, Cori GT. The Carbohydrate Metabolism Of Tumors. II. Changes In The Sugar, Lactic Acid, And Co -Combining Power Of Blood Passing Through A Tumor. mJ. Biol. Chem. 1925, 65:397-405.
Costa AF, Tasso MG, Mariano FV, Soares AB, Chone CT, Crespo AN, Fresno MF, Llorente JL, Suárez C, de Araújo VC, Hermsen M, Altemani A. Levels and patterns of expression of hypoxia-inducible factor-1α, vascular endothelial growth factor, glucose transporter-1 and CD105 in adenoid cystic carcinomas with high-grade transformation. Histopathology. 2012 Apr;60(5):816-25.
Courtnay R, Ngo DC, Malik N, Ververis K, Tortorella SM, Karagiannis TC. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol Biol Rep. 2015 Apr;42(4):841-51. Cusano NE, Kiel DP, Demissie S, Karasik D, Adrienne Cupples L, Corella D, Gao Q, Richardson K, Yiannakouris N, Ordovas JM. A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study. Calcif Tissue Int. 2012 Feb;90(2):96-107.
Dann CE, Bruick RK, Deisenhofer J. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci USA. 2002 Nov 26;99(24):15351-6.
de Andrade BA, León JE, Carlos R, Delgado-Azañero W, Mosqueda-Taylor A, Graner E, de Almeida OP. Expression of fatty acid synthase (FASN) in oral nevi and melanoma. Oral Dis. 2011 Nov;17(8):808-12.
de Angelis, CM. Avaliação da expressão da enzima ácido graxo sintase (FASN) em carcinomas de glândulas salivares [dissertação]. Campinas: Faculdade de Ciências Médicas, Universidade Estadual de Campinas; 2019.
de Araújo VC, Altemani A, Furuse C, Martins MT, de Araújo NS. Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol. 2006 Nov;42(10):1011-6.
de Araújo VC, Furuse C, Cury PR, Altemani A, Alves VA, de Araújo NS. Desmoplasia in different degrees of invasion of carcinoma ex-pleomorphic adenoma. Head Neck Pathol. 2007 Dec;1(2):112-7.
de Brito BS, Giovanelli N, Egal ES, Sánchez-Romero C, Nascimento JS, Martins AS, Tincani ÁJ, Del Negro A, Gondak RO, Almeida OP, Kowalski LP, Altemani A, Mariano FV. Loss of expression of Plag1 in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma. Hum Pathol. 2016 Nov;57:152-159.
de Morais EF, Pinheiro JC, Sena DAC, Galvão HC, de Souza LB, de Almeida Freitas R. Extracapsular invasion: A potential prognostic marker for Carcinoma ex-pleomorphic adenoma of the salivary glands? A Systematic Review. J Oral Pathol Med. 2019 Feb 13.
de Souza LB, de Oliveira LC, Nonaka CFW, Lopes MLDS, Pinto LP, Queiroz LMG. Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands. Eur Arch Otorhinolaryngol. 2017 Jun;274(6):2549-2556.
de Berardinis RJ, Chandel NS. Fundamentals of cancer metabolism. Sci Adv. 2016 May 27;2(5):e1600200.
Demasi AP, Costa AF, Altemani A, Furuse C, Araújo NS, Araújo VC. Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. Int J Exp Pathol. 2010 Apr;91(2):107-13.
Deng Y, Zou J, Deng T, Liu J. Clinicopathological and prognostic significance of GLUT1 in breast cancer: A meta-analysis. Medicine (Baltimore). 2018 Nov;97(48):e12961.
Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer. 2008 Sep;8(9):705-13.
Di Palma S. Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol. 2013 Jul;7 Suppl 1:S68-76.
Díaz KP, Gondak R, Martins LL, de Almeida OP, León JE, Mariano FV, Altemani A, Vargas PA. Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of
malignant component in carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 2019 Mar;48(3):232-238.
Ding CS, Yap WM, Teo CH, Giron D, Chuah KL. Tracheal carcinoma ex pleomorphic adenoma: a rare tumour with potential problems in diagnosis. Histopathology. 2007 Dec;51(6):868-71.
do Prado RF, da Silva Machado AL, Colombo CE, Carvalho YR. Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors. J Oral Pathol Med. 2011 Jul;40(6):467-75.
dos Santos HT, Silva RN, Piña AR, de Souza do Nascimento J, de Almeida OP, Egal ES, de Andrade BA, Mariano FV, Altemani A. Lipid droplets are involved in the process of high-grade transformation of adenoid cystic carcinoma. Histopathology. 2016 Jul;69(1):160-2.
dos Santos HT. Gotas lipídicas intracitoplasmáticas em carcinomas de glândulas salivares: estudo imunohistoquímico. [Dissertação] Piracicaba: Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas; 2014.
Dulguerov P, Todic J, Pusztaszeri M, Alotaibi NH. Why Do Parotid Pleomorphic Adenomas Recur? A Systematic Review of Pathological and Surgical Variables. Front Surg. 2017 May 15;4:26.
Eastman SW, Yassaee M, Bieniasz PD. A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. J Cell Biol. 2009 Mar 23;184(6):881-94.
Egal ES, Mariano FV, Altemani AM, Metze K. Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma. Oral Oncol. 2018 Sep; 84:106-107.
Ellis GL, Auclair PL. Atlas of tumor pathology tumors of the salivary glands. 4rd ed. AFIP; 2008;155-373.
El-Naggar AK, Chan JK, Grandis Jennifer R, Takata T, Slootweg PJ, organizadores. WHO Classif Head Neck Tumours. Fourth. 2017;347p.
Endo Y, Ohashi R, Inai S, Yokoshima K, Nakamizo M, Shimizu A, Okubo K, Naito Z. Carcinosarcoma ex Pleomorphic Adenoma of the Submandibular Gland in a 64-Year-Old Man: A Case Report. J Nippon Med Sch. 2018;85(1):51-55.
Espinosa CA, Fernández-Valle A, Lequerica-Fernández P, Villalaín L, de Vicente JC. Clinicopathologic and Surgical Study of Pleomorphic Adenoma of the Parotid Gland: Analysis of Risk Factors for Recurrence and Facial Nerve Dysfunction. 2018 Feb:76(2): 347-354. Eveson JW, Auclair PL, Gnepp DR, El-Naggar AK. Tumours of the salivary gland. In:Barnes L, Eveson JW, Reichart P, Sidransky D, (Eds.). World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Lyon: IARC; 2005;164.
Eveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol 1985 146(1):51–8.
Fei X, Qi M, Wu B, Song Y, Wang Y, Li T. MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression. FEBS Lett. 2012 Feb 17;586(4):392-7.
Fenske W, Völker HU, Adam P, Hahner S, Johanssen S, Wortmann S, Schmidt M, Morcos M, Müller-Hermelink HK, Allolio B, Fassnacht M. Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome inadrenocortical carcinoma. Endocr Relat Cancer. 2009 Sep;16(3):919-28.
Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019
Ferreira LM. Cancer metabolism: the Warburg effect today. Exp Mol Pathol. 2010 Dec;89(3):372-80.
Fiorentzis M, Kalirai H, Katopodis P, Coupland SE. Adipophilin expression in primary and metastatic uveal melanoma: a pilot study. Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):1049-1051.
Flavin R, Peluso S, Nguyen PL, Loda M. Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol. 2010 Apr;6(4):551-62.
Frazell EL. Clinical aspects of tumors of the major salivary glands. Cancer. 1954 Jul;7(4):637- 59.
Fujimoto M, Matsuzaki I, Yamamoto Y, Yoshizawa A, Warigaya K, Iwahashi Y, Kojima F, Furukawa F, Murata SI. Adipophilin expression in cutaneous malignant melanoma. J Cutan Pathol. 2016; 44:228–236.
Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, Kamada S, Saito K, Iiizumi M, Liu W, Ericsson J, Watabe K. Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res. 2008 Feb 15;68(4):1003-11.
Gaissert HA, Mark EJ. Tracheobronchial gland tumors. Cancer Control. 2006 Oct;13(4):286- 94.
Galochkina T, Ng Fuk Chong M, Challali L, Abbar S, Etchebest C. New insights into GluT1 mechanics during glucose transfer. Sci Rep. 2019 Jan 30;9(1):998.
Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther. 2009 Jan;121(1):29-40.
Gentric G, Mieulet V, Mechta-Grigoriou F. Heterogeneity in Cancer Metabolism: New Concepts in an Old Field. Antioxid Redox Signal. 2017 Mar 20;26(9):462-485.
Giatromanolaki A, Sivridis E, Arelaki S, Koukourakis MI. Expression of enzymes related to glucose metabolism in non-small cell lung cancer and prognosis. Exp Lung Res. 2017 May - Jun;43(4-5):167-174.
Gnepp DR. Malignant mixed tumors of the salivary glands: a review. Pathol Annu. 1993;28 Pt 1:279-328.
Godoy A, Ulloa V, Rodríguez F, Reinicke K, Yañez AJ, García Mde L, Medina RA, Carrasco M, Barberis S, Castro T, Martínez F, Koch X, Vera JC, Poblete MT, Figueroa CD, Peruzzo B, Pérez F, Nualart F. Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol. 2006 Jun;207(3):614-27.
Gonzalez-Menendez P, Hevia D, Alonso-Arias R, Alvarez-Artime A, Rodriguez-Garcia A, Kinet S, Gonzalez-Pola I, Taylor N, Mayo JC, Sainz RM. GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress. Redox Biol. 2018 Jul; 17:112-127.
Gonzalez-Menendez P, Hevia D, Rodriguez-Garcia A, Mayo JC, Sainz RM. Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells. Endocrinology. 2014 Sep;155(9):3238-50.
Graner E, Tang D, Rossi S, Baron A, Migita T, Weinstein LJ, Lechpammer M, Huesken D, Zimmermann J, Signoretti S, Loda M. The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. Cancer Cell. 2004 Mar;5(3):253-61.
Griffith CC, Thompson LD, Assaad A, Purgina BM, Lai C, Bauman JE, Weinreb I, Seethala RR, Chiosea SI Salivary duct carcinoma and the concept of “early carcinoma ex pleomorphic adenoma”. Histopathology 2014 65(6):854–860
Grimm M, Munz A, Teriete P, Nadtotschi T, Reinert S. GLUT-1(+) /TKTL1(+) coexpression predicts poor outcome in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jun;117(6):743-53.
Hall AM, Brunt EM, Chen Z, Viswakarma N, Reddy JK, Wolins NE, Finck BN. Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice. J Lipid Res. 2010 Mar;51(3):554-63.
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4; 144(5):646-74.
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7; 100(1):57-70.
Hara S, Nakashiro K, Klosek SK, Ishikawa T, Shintani S, Hamakawa H. Hypoxia enhances c- Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells. Oral Oncol. 2006 Jul;42(6):593-8.
Harguindey S, Orive G, Luis Pedraz J, Paradiso A, Reshkin SJ. The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature. Biochim Biophys Acta. 2005 Sep 25;1756(1):1-24.
Harrison H, Pegg HJ, Thompson J, Bates C, Shore P. HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells. BMC Cancer. 2018 Jun 20;18(1):674. Harrison W, Pittman P, Cummings T. Pleomorphic adenoma of the lacrimal gland: A review with updates on malignant transformation and molecular genetics. Saudi J Ophthalmol. 2018 Jan-Mar;32(1):13-16.
Hatanaka M. Transport of sugars in tumor cell membranes. Biochim Biophys Acta. 1974 Apr 29;355(1):77-104.
Haugland HK, Vukovic V, Pintilie M, et al. Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation. Int J Radiat Oncol Biol Phys. 2002; 53:854–861.
Hayes MM, Lesack D, Girardet C, Del Vecchio M, Eusebi V. Carcinoma ex-pleomorphic adenoma of the breast. Report of three cases suggesting a relationship to metaplastic carcinoma of matrix-producing type. Virchows Arch. 2005 Feb;446(2):142-9.
Henriksson G, Westrin KM, Carlsöö B, Silfverswärd C. Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 1998 Feb 15;82(4):617-20.
Horiuchi C, Tsukuda M, Taguchi T, Ishiguro Y, Okudera K, Inoue T. Correlation between FDG-PET findings and GLUT1 expression in salivary gland pleomorphic adenomas. Ann Nucl Med. 2008 Oct;22(8):693-8.
Horree N, Gort EH, Van der Groep P, et al. Hypoxia‐inducible factor 1α is essential for hypoxic p27 induction in endometrioid endometrial carcinoma. J Pathol. 2008; 214:38–45. Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell. 2008 Sep