Desenvolvimento de um modelo experimental de hidrocefalia por neurocisticercose

(1)

!! !

!

UNIVERSIDADE ESTADUAL PAULISTA

“JÚLIO DE MESQUITA FILHO”

FACULDADE DE MEDICINA

! ! ! ! ! ! ! ! !

Pedro Tadao Hamamoto Filho

! ! ! ! ! ! ! ! ! !

Desenvolvimento de um Modelo Experimental de

Hidrocefalia por Neurocisticercose

! ! ! ! ! ! ! ! ! !

Dissertação apresentada à

Faculdade de Medicina,

Universidade Estadual Paulista

“Júlio de Mesquita Filho”, Câmpus de Botucatu, para obtenção do título de Mestre em Bases Gerais da Cirurgia !! !! !! ! !

(2)

!! !!

! ! !

Pedro Tadao Hamamoto Filho

! ! ! ! ! ! ! ! !

Desenvolvimento de um Modelo Experimental

de Hidrocefalia por Neurocisticercose

!! !! !! ! ! ! ! ! ! !

Dissertação apresentada à

Faculdade de Medicina,

Universidade Estadual Paulista “Júlio de Mesquita Filho”, Câmpus de Botucatu, para obtenção do título de Mestre em Bases Gerais da Cirurgia !! !! !! !! ! ! ! ! !

Orientador: Prof. Dr. Marco Antônio Zanini

(3)

Palavras-chave: Hidrocefalia; Modelo experimental; Neurocisticercose.

Hamamoto Filho, Pedro Tadao.

Desenvolvimento de um modelo experimental de

hidrocefalia por neurocisticercose / Pedro Tadao Hamamoto Filho. - Botucatu, 2015

Dissertação (mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina de

Botucatu

Orientador: Marco Antônio Zanini Capes: 40102084

1. Hidrocefalia - Tratamento. 2. Cérebro - Doenças. 3. Neurocisticercose - Estudos experimentais.

(4)

!"#$%&'()$&_! ! ! ! ! !

!"#$%&'"()*+,"$"-.&/-()0+,"1)"$2-&34.5-)'"/,("6$"3$("5,.1%*-1,")37")8%-'"/,("6$"($)9-*)(",&"

&,.:,&'"/,("$&3)("&$6/($"5,6-;,<""

!

(5)

!"#$%&'()&*+,-. !

!

"#!$%#&'!()%*#!"+,-+.#!/)+.+.0!123!#%.2+,)4#%0!5%2*25,#%!2!126,%20!5#%!6215%2!12! .+*2+,.7)%0!5#%!12!&#%1)%!+23%#*.%3%8.9#0!2!5#%!62%!#!2:215;#!42!5%#&.66.#+);!21!<321!12!

2652;=#>!+#!*3.4)4#!*#1!#6!5)*.2+,26!2!+)!2:*2;?+*.)!4)!,@*+.*)!*.%A%8.*)'! !

B!C3;.)+)0!123!)1#%0!1.+=)!*#15)+=.)0!5#%!12!2+*=2%!#6!4.)6!42!);28%.)!2!#!&3,3%#!42! 2652%)+D)0!&2;.*.4)42!2!)1#%'!

!

B!1.+=)!192!";.*20!5#%!12!,2%!4)4#!#!<32!42!12;=#%!62!5#42!4)%!)#6!&.;=#6>!243*)D9#!2! *)%E,2%F!5#%!,2%!6.4#!5).!2!192F!5#%!62%!2:215;#!42!7.4)'!

!

B!1.+=)!.%19!$%.6*.;)0!)1.8)!42!,)+,)6!=#%)60!52;#!)1#%0!)5#.#!2!.+*2+,.7#!42!6215%2'! !

"#!$%#&'!G#H2%,#!I#;.*=.#!J)H)%%)0!5#%!12!,2%!%2*2H.4#!+)!K23%#*.%3%8.)!*#1#!5).0!52;#! )&2,#!*#1!<32!6215%2!12!.+*2+,.7#3'!

!

"#6!5%#&266#%26!G#4%.8#!L)M)+0!N3.M!I)%;#6!O3;*)+#!2!J2%1)+#!P%)+*.6*#!L.#+4.!52;#! )5#.#!5)%)!)!%2);.M)D9#!426,2!,%)H);=#'!

!

B!()%.)++)!O)M!G#4%.83260!Q.28#!J2+2%#6#0!R2%);4#!"+4%@!I),);)+!G#6)0!!C#6@!"+,#+.#! J2%1.+.)+#!2!R@;.#!G3H2+6!42!I)%7);=#!K3+260!5#%!*#;)H#%)%21!+)6!4.72%6)6!2,)5)6!4)!

%2);.M)D9#!4#!,%)H);=#'! !

"#!Q%'!";2:)+4%2!S#4#%#7.*!P)H%#0!52;)!*#;)H#%)D9#!+)!)+E;.62!=.6,#;T8.*)'! !

"#6!&3+*.#+E%.#6!4#!Q25)%,)12+,#!42!K23%#;#8.)0!$6.*#;#8.)!2!$6.<3.),%.)>!O)+42%*.! (#%2.%)0!"4%.)+#!U2;5.60!J2%);4#!4#6!U)+,#6!2!O)+266)!K)=6)+0!52;)!)V34)!*#,.4.)+)'!

! ! !

(6)

!"#$%&!

! '

'

("#")*&+*,%")-&' ."' $%' %&."+&' "/0"1,%")-2+' ."' 3,.1&4"52+,2' 0&1'

)"$1&4,#-,4"14&#"!

"#$%&'()*('#%'&)#! +! ,! -&#./,! 0,%,)(*1%(,! 2,()! '&2$2! -&! )()*#2,! .#%3&)&! '#.*%,45! 6!

',$),-,! 0#4,! (.7#)*8&! -#! &3&)! -#!!"#$%"& '()%*+9! '$:,)! 4,%3,)! )#! (.)*,4,2! .&)! -(3#%)&)!

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

.#$%&'()*('#%'&)#5!M.&'$4,2&)!'()*&)!-#!!"#$%"&,-"''%,#.'&N'#)*&-&!,.14&7&!,&!!/&'()%*+O!

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

J,4,3%,)S'@,3#T!@(-%&'#=,4(,U!.#$%&'()*('#%'&)#U!2&-#4&!#E0#%(2#.*,4! !

(7)

!"#$%&'$(

( (

(

)*+*,-./*0$( -1( &0( *2.*%3/*0$&,( /-4*,( 0*5%-'6#$3'*%'-#3#73045'*4(

864%-'*.8&,5#(

!"#$%&'()*&"$&%(*(+*(+),"+-%()+&%--%.+/0$0(*)*&+1*("0("+%2+),"+&".)$03+."$4%#(+('()"-5+

6)+*(+&0#("1+7'+),"+*.8"()*%.+%2+"88(+2$%-+!"#$%"&'()%*+9+:,%("+30$40"+3%18"+*.+),"+7$0*.+

0.1+ *.)$0&$0.*03+ &%-/0$)-".)(5+ ;."+ %2+ ),"+ -0*.+ &%-/3*&0)*%.(+ %2+ ."#$%&'()*&"$&%(*(+ *(+

,'1$%&"/,03#(9+ :,*&,+ -0'+ 7"+ /$"(".)+ *.+ #/+ )%+ <=>+ %2+ /0)*".)(5+ ?$"0)-".)+ %2+

,'1$%&"/,03#(+ *.+ ."#$%&'()*&"$&%(*(+ *(+ -%$"+ 1*22*&#3)+ ),0.+ *.+ %),"$+ 2%$-(+ %2+

,'1$%&"/,03#(5+?,"$"+0$"+,*8,+$0)"(+%2+4".)$*&3"@/"$*)%."03+(,#.)+-032#.&)*%.9+-%$7*)'+

0.1+ 1"0),5+ A"&".)+ "B/"$*-".)03+ -%1"3(+ %2+ ."#$%&'()*&"$&%(*(+ ,04"+ 2%&#("1+ %.+ ),"+

/0$0(*)"@,%()+ *.)"$0&)*%.5+ ;.+ ),"+ %),"$+ ,0.19+ "B/"$*-".)03+ -%1"3(+ %2+ ,'1$%&"/,03#(+

0&&%-/3*(,"1+ 2%$+ ),"+ #.1"$()0.1*.8+ %2+ 7$0*.(+ 3"(*%.(+ 1")"$-*."1+ 7'+ ),"+ *-7030.&"+ %2+

/$%1#&)*%.9+&*$&#30)*%.+0.1+07(%$/)*%.+%2+&"$"7$%@(/*.03+23#*15+C"+0*-"1+)%+1"4"3%/+0.+

"B/"$*-".)03+ -%1"3+ %2+ ."#$%&'()*&"$&%(*(@*.1#&"1+ ,'1$%&"/,03#(5+ C"+ *.%&#30)"1+ &'()(+

2$%-+!"#$%"&,-"''%,#.'+D0+&"()%1"+(*-*30$+)%+!/&'()%*+E+*.+),"+(#70$0&,.%*1+(/0&"+%2+$0)(+

),$%#8,+ 0+ (#7%&&*/*)03+ /#.&)*%.+ %2+ ),"+ &*()"$.0+ -08.05+ F08.")*&+ $"(%.0.&"+ *-08*.8+

(,%:"1+ 4".)$*&3"+ 0.1+ 70(03+ &*()"$.(+ ".30$8"-".)5+ F*&$%(&%/*&+ 0(("((-".)+

1"-%.()$0)"1+ 7$0*.+ 3"(*%.(+ *.1#&"1+ 7'+ ,'1$%&"/,03#(+ 0.1+ *.230--0)%$'+ *.2*3)$0)"(+ )%+

),"+ &"$"7$%@(/*.03+ 23#*1+ &%-/0$)-".)(5+ ?,"("+ 2*.1*.8(+ $"/$%1#&"1+ ,#-0.+

."#$%&'()*&"$&%(*(@*.1#&"1+ ,'1$%&"/,03#(G+ -"&,0.*&03+ %7()$#&)*%.+ %2+ ),"+ &"$"7$%@

(/*.03+ 23#*1+ &*$&#30)*%.+ 0.1+ *.230--0)%$'+ *.2*3)$0)"(+ 2$%-+ ),"+ ,%()+ *--#."+ $"(/%.("+

080*.()+),"+/0$0(*)"5+

+

(8)

!"#$%&'()#'*+$+,&-.'*!

+ + "#$%&!'!()*(+,-./(%&!

012!'!34/5-(6!/4-7,*8!89854:!

02;!'!34-4<-,8+./(6!=6*.>!

0?!'!3,:+*54-.@4>!5,:,A-(+B9!

CD"!'!C85(>,8!D/.>,8!>(!":E-.3(!

F!'!F(*A4!

GC!'!B4:(5,H.6./(!4!4,8./(!

IJ!'!)*(-5,!K74/5-L3*6,M!

NA!'!)*.6,A-(:(!

:6!'!:.6.6.5-,!

::!'!:.6L:45-,!

::O_{!'!:.6L:45-,!3P<.3,!}

QRI!'!:(A/45.3!-48,/(/34!.:(A./A!

:8!'!:.6.884A*/>,!

,_{0!'!A-(*8!0468.*8!}

RQ!'!-488,/S/3.(!:(A/E5.3(!

210!'!8.854:(!/4-7,8(!34/5-(6!

?!'!5486(!

?B!'!?!B46+4-!3466!

D1C2$!'!D/.74-8.>(>4!C85(>*(6!$(*6.85(!

D2"!'!D/.54>!25(548!,=!":4-.3(!

J$!'!74/5-.364%+4-.5,/4(6!!"#$%&'(

(9)

!

"#$%&'(_! !

!

"#$%&'()*&!+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++,!

!"#$%!,!-!.%$/0&!'1!213/4*&!5+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++6!

7(4$/8/9:$/3:!5+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++;;!

<=>1$/3&4!5++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++;?!

@:$1%/:/4!1!@A$&'&4!5+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++;6!

214(B$:'&4!5+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++C;!

!"#$%!;!-!.%$/0&!'1!214(B$:'&4+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++CC!

!"#$%!C!-!.%$/0&!'1!214(B$:'&4+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++?D!

E/49(44*&!555++55555555555555555555555555555555555555+5DD!

F&#9B(4G14!55+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++6,!

2181%H#9/:4!5+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++6C!

F&IJ%&3:#$1!'1!:J%&3:)*&!'&!J%&>1$&!'1!J14K(/4:!J1B&!FLM.!5555555555555+6N!!!

.#1O&4!5555+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++6P!

!

(10)

(11)

#" !"#$%&'()%"

" $%&'()*+,*)%')(+%" -" ." /'*0)*/.1" 2(%03." /.'.+*,4'*." 2(" +*+,%5." 0%'6(+." )%0,'.1"

78$9:" %5" ,(2(" (" 5&02(" 7;1*++%'" %," .1<=" #>>?:<" @" ,.5A-5" &5." ).&+." *5/(',.0,%" 2%"

%/*1%/+*.".2B&*'*2."0."*2.2%".2&1,."%5"'%C*D%+"%02E5*).+"79(F1%="#>!G:<"H/%+.'"2%"+%&"

/(,%0)*.1" 2%" %''.2*).3I(" .,'.6-+" 2%" 5%2*2.+" +.0*,4'*.+=" ." 0%&'()*+,*)%')(+%" -" &5."

2(%03." 0%C1*C%0)*.2." %" /%'5.0%)%" %02E5*)." 0." H5-'*)." J.,*0.=" KL'*)." 8&AM8..'*.0." %"

%5".1C&5.+"'%C*D%+"2."K+*.<";1&N(+"5*C'.,O'*(+"+I("'%+/(0+46%*+"/%1("./.'%)*5%0,("2%"

0(6(+" ).+(+" 0(+" P+,.2(+" Q0*2(+" %" P&'(/." 7R.11*0" %" S&',TU%=" #>>GV" 9(F1%" %," .1<=" #>!#V"

WX$%.1"%";1%)U%'="#>!Y:<"

" $%&'()*+,*)%')(+%" -" &5." 2(%03." /1%(5O'L*)." 79.'/*(" %," .1<=" #>!?:<" 9*+,(+" 2%"

!"#$%"&'()%*+"/(2%5"+%".1(Z.'"%5"B&.1B&%'"%+/.3("2("+*+,%5."0%'6(+(")%0,'.1<"$."L('5."

5.*+")(5&5="(+")*+,(+"+I("%0)(0,'.2(+"0("/.'E0B&*5.")%'%A'.1"%"/(2%5").&+.'")'*+%+"

%/*1-/,*).+=")%L.1%*."%"2-L*)*,+"L().*+"7[.')*."%,".1<="#>!G:<"$."L('5."%N,'./.'%0B&*5.,(+.="

(+")*+,(+"/(2%5"+%"1().1*T.'"0."5%2&1."%+/*0\.1="0("C1(A("()&1.'"(&"0(+")(5/.',*5%0,(+"

1*B&O'*)(+<" 9*+,(+" %5" L('5." 2%" ).)\(+" 2%" &6." 0(" %+/.3(" +&A.'.)0O*2%(" ).&+.5" ."

)\.5.2." 0%&'()*+,*)%')(+%" '.)%5(+.<" $." L('5." %N,'./.'%0B&*5.,(+." " \4" 64'*.+"

)(5/1*).3D%+" )(5(" 6.+)&1*,%" 7)(5" )(0+%B&%0,%+" .)*2%0,%+" 6.+)&1.'%+" )%'%A'.*+:="

0%&'(/.,*." 2%" 0%'6(+" )'.0*.0(+=" 5%0*0C*,%" )*+,*)%')O,*).=" \*2'()%L.1*.=" \*/%',%0+I("

*0,'.)'.0*.0."%"5(',%"7P+,.](1"%,".1<="!^_`V"a.\.1%"%,".1<="#>!Y:<"

" 9*+,(+" 0(+" %+/.3(+" 1*B&O'*)(+" %6().5" '%+/(+,.+" *0L1.5.,O'*.+" B&%" ).&+.5"

%/%02*5*,%="6%0,'*)&1*,%"%".'.)0(*2*,%<"9(5(")(0+%B&E0)*.="\4"&5"2%+%B&*1bA'*("0."1*6'%"

)*')&1.3I(" 2%" 1bB&('<" 9*+,(+" *0,'.6%0,'*)&1.'%+" ,.5A-5" /(2%5" ).&+.'" (A+,'&3I("

5%)c0*).".("L1&N("1*B&O'*)(<"W"'%+&1,.2("2%+,%+"5%).0*+5(+"-"."\*2'()%L.1*."7a.,&+\*,."

(12)

?" " d*2'()%L.1*." 0." 0%&'()*+,*)%')(+%" -" &5" /'(A1%5." 2%+.L*.2('" /.'."

0%&'()*'&'C*D%+<" e*L%'%0,%5%0,%" 2%" (&,'.+" ).&+.+" 2%" \*2'()%L.1*.=" (" 5.0%Z(" )1b0*)(" %"

)*'f'C*)(" -" 5.*+" )(5/1%N(" 79(11*" %," .1<=" #>>#?<" e'(C.+" .0,*/.'.+*,4'*.+" '(,*0%*'.5%0,%"

&,*1*T.2.+" 0." L('5." /.'%0B&*5.,(+." 0I(" +I(" ,I(" %L%,*6.+" )(0,'." )*+,(+" 0(+"

)(5/.',*5%0,(+"1*B&O'*)(+"%"/(2%5="*0)1&+*6%="/*('.'"."'%+/(+,."*0L1.5.,O'*."7[.')b."%,"

.1<=" #>>#?<" g('" (&,'(" 1.2(=" .+" 2%'*6.3D%+" 6%0,'*)&1.'%+" &,*1*T.2.+" /.'." \*2'()%L.1*." ,E5"

'*+)(" )(0+*2%'46%1" 2%" 2*+L&03D%+" %" *0L%)3D%+=" 2%5.02.02(" '%6*+D%+" )*'f'C*).+"

L'%B&%0,%+"7S%11%F"%,".1<="#>>#?<"H"0%&'(%02(+)(/*."-"&5.",-)0*)."B&%"5&*,(")(0,'*A&*&"

0(" ,'.,.5%0,(" 2." \*2'()%L.1*." /('" 0%&'()*+,*)%')(+%" /('-5" 0I(" -" %L*).T" %5" ,(2(+" (+"

).+(+"7h.0C%1M9.+,*11."%,".1<="#>>^?<"

" W" ,'.,.5%0,(" 2." 0%&'()*+,*)%')(+%" /%'5.0%)%" %5" 2*+)&++I(" %=" ./%+.'" 2(+"

.6.03(+"%"%6*2E0)*.+=".*02.",%5"5&*,.+"B&%+,D%+"."+%'%5"'%+/(02*2.+<"8%"/('"&5"1.2(="

5.*+" %0+.*(+" )1b0*)(+" +I(" 0%)%++4'*(+=" /('" (&,'(" 1.2(=" ." )(5/'%%0+I(" )(5/1%,." 2%"

5%).0*+5(+" L*+*(/.,(1OC*)(+" %5" \&5.0(+" -" 1*5*,.2." /%1." %+).++%T" 2%" ,%)*2(+"

2*+/(0b6%*+" %" /%1." *0,%'L%'E0)*." 2(" ,'.,.5%0,(" )(5" )(',*)(,%'./*.<" H++*5=" %+,&2(+" )(5"

/%+B&*+." A4+*)." +I(" ,.5A-5" 0%)%++4'*(+" /.'." 2%,%'5*0.'" ." 0.,&'%T." 2(" /'()%++("

*0L1.5.,O'*("B&%"()(''%"0."0%&'()*+,*)%')(+%"7$.+\"%,".1<="#>>`?<"P+,%+"%+,&2(+"/(2%'I("

\.A*1*,.'".")(5&0*2.2%")*%0,bL*).".")(5/'%%02%'"5%1\('"(+"5%).0*+5(+"%"5(2&1.2('%+"

2."*0L1.5.3I("%".++*5"/'(/('"0(6(+".16(+",%'./E&,*)(+<"

" P+,&2(+" )(5" 0%&'()*+,*)%')(+%" %N/%'*5%0,.1" ,E5" +*2(" /&A1*).2(+=" /('-5" )(5"

E0L.+%"0."L('5."/.'%0B&*5.,(+."2."2(%03.<"9(0,'*A&*3D%+"%+/%)*.*+"6*%'.5"2("C'&/("2%"

H16.'%T" %" i%.1%<" P+,%" C'&/(" )'*(&" &5" 5(2%1(" 2%" *0()&1.3I(" 2(" )%+,(2(",#'(-#'.(%/#'&

-(0.%_{" 0." )(06%N*2.2%" )%'%A'.1" 2%" ).5&02(0C(+<" 8%&+" '%+&1,.2(+" 5(+,'.'.5" .+" 6*.+" 2%"}

5*C'.3I(" 1%&)()*,4'*." 2(+" 6.+(+" /.'." (" ,%)*2(" )%'%A'.1=" .+" /'(,%b0.+" 2(" )(5/1%N("

(13)

G" %"("/.2'I(")%1&1.'"'%)'&,.2("0."'%+/(+,.")(0,'."("/.'.+*,."79.'2(0."%,".1<="!^^^V"H16.'%T"

%" i%.1%=" #>>jV" H16.'%T" %" i%.1%=" #>>_:<" $(" %0,.0,(=" %+,%" )%+,(2(" ,%5" ." )./.)*2.2%" 2%"

/%0%,'.'" %" *06.2*'" (" /.'E0B&*5." )%'%A'.1=" (" B&%" 0I(" )(''%+/(02%" .(" )(5/(',.5%0,("

A*(1OC*)("2."!1&'()%*+"0("+*+,%5."0%'6(+(")%0,'.1<"

" P5" '%6*+I(" +(A'%" 5(2%1(+" %N/%'*5%0,.*+" 2%" 0%&'()*+,*)%')(+%=" %+,%" C'&/(" 2%"

.&,('%+"./(0,."&5"(&,'(")%+,(2("+*5*1.'"k"!1&'()%*+"B&%"/(2%'*."+%'"&,*1*T.2(l",'.,.M+%"

2."!"#$%"& -0"''%-#2'<" g('-5" %+,%" /.'.+*,." 2*+,(')%" .+" %+,'&,&'.+" *0,'.)'.0*.0.+=" (" B&%"

+%'*." &5." 1*5*,.3I(" 2%" +%&" &+(" )(5(" 5(2%1(" %N/%'*5%0,.1" 7H16.'%T" %," .1<=" #>!>:<" g('"

(&,'(" 1.2(=" ." 2*+,('3I(" 2(" ,%)*2(" 0%'6(+(" -" &5." 2.+" ).'.),%'b+,*).+" 2." L('5."

%N,'./.'%0B&*5.,(+."2."0%&'()*+,*)%')(+%<"

" !1& -0"''%-#2'" -" &5" /1.,%15*0,(" )&Z(+" \(+/%2%*'(+" *0,%'5%2*4'*(+" +I(" '(%2('%+"

+*16%+,'%+" %" )&Z(+" \(+/%2%*'(+" 2%L*0*,*6(+" +I(" 1(A(+=" './(+.+" %" )I%+<" P+,%" /.'.+*,." ,%5"

&5."C'.02%")./.)*2.2%"/'(1*L%'.,*6.l"(+")*+,*)%')(+"/(2%5"+%'"%N,'.b2(+"2%"'(%2('%+"%"

5.0,*2(+" *02%L*0*2.5%0,%" 0." ).6*2.2%" /%'*,(0%.1" 2%" ).5&02(0C(+=" (02%" +%"

'%/'(2&T%5"2%"L('5.".++%N&.2."/('"C%5&1.3I("7R*115+"%"m.'&A*.0="#>!>:<"

" a.,(+M8*16." %" )(1.A('.2('%+" 7#>!#:" *0()&1.'.5"!1& -0"''%-#2'" 0(" /.'E0B&*5."

)%'%A'.1" 2%" ).5&02(0C(+" %" (A+%'6.'.5" 2*L%'%0,%+" /.2'D%+" 2%" *0L1.5.3I(" 2%" .)('2("

)(5" ." 1*0\.C%5" 2(+" .0*5.*+<" g('" .).+(=" (A+%'6.'.5" 6%0,'*)&1(5%C.1*." %5" .1C&0+"

.0*5.*+="/('-5"%+,%"0I("L(*"("(AZ%,*6("2("%+,&2("%"0%5"'%)%A%&"5.*('"2%,.1\.5%0,(<"

" ;*0.15%0,%="5(2%1(+"%N/%'*5%0,.*+"2%"\*2'()%L.1*.",E5"+*2("%+,&2.2(+"\4"5&*,("

,%5/(<" e%" L.,(=" \4" 5.*+" 2%" )%5" .0(+=" (+" %+,&2(+" 2%" e.02F" L('.5" L&02.5%0,.*+" /.'." ."

)(5/'%%0+I(" 2." L*+*(1(C*." 0('5.1" 2." )*')&1.3I(" 1*B&O'*)." 7e.02F" %" n1.)UL.0=" !^!G:<"

e%+2%" %0,I(=" 2*L%'%0,%+" +&A+,c0)*.+" L('.5" %5/'%C.2.+" 0." ,%0,.,*6." 2%" *02&T*'"

\*2'()%L.1*."%N/%'*5%0,.15%0,%"7d()\o.12="!^_Y:<"W".C%0,%"5.*+")(5&5%0,%"&,*1*T.2("

(14)

Y" A.'.,." %" %L%,*6." /.'." *02&T*'" \*2'()%L.1*." %5" .0*5.*+<" P+,%" 5(2%1(" ,%5" +*2(" 5&*,(" f,*1" /.'.".")(5/'%%0+I("2%".1,%'.3D%+"%+,'&,&'.*+=")(5/(',.5%0,.*+"%"'.2*(1OC*).+").&+.2.+" /%1." \*2'()%L.1*."7e%1" n*C*(="!^^?V" J(/%+" %," .1<="#>>^V" 8UZ(12*0C" %," .1<="#>!>V" W1(/.2%"%," .1<=" #>!#:<" g('-5" ." \*2'()%L.1*." *02&T*2." /%1(" ).&1*5" C%'.15%0,%" -" './*2.5%0,%" /'(C'%++*6."%").&+.".2(%)*5%0,("*5/(',.0,%"2(+".0*5.*+="("B&%"1*5*,.".041*+%+"."1(0C("

(15)

(16)

Y`" L269'66)%*

" P+,&2(+" %N/%'*5%0,.*+" +I(" f,%*+" %" 0%)%++4'*(+" /.'." (" %0,%02*5%0,(" 2(+"

5%).0*+5(+" L*+*(/.,(1OC*)(+" %06(16*2(+" 0.+" 2(%03.+=" %+/%)*.15%0,%" /.'." .B&%1.+" )&Z("

%+,&2(" 2%,.1\.2(" 2%" 5%).0*+5(+" +%Z." 2*L*)&1,.2(" /%1." 6.'*.A*1*2.2%" 2%" ./'%+%0,.3I("

)1b0*)."%"/%1."*0L1&E0)*."2("/'O/'*(",'.,.5%0,(=")(5("-"(").+("2."0%&'()*+,*)%')(+%<"

" e*6%'+(+" %+,&2(+" %N/%'*5%0,.*+" ,E5" +*2(" /&A1*).2(+" )(5" L()(" 0." L('5."

/.'%0B&*5.,(+." 2." 0%&'()*+,*)%')(+%<" g('-5" 0." /'4,*)." )1b0*)." ." L('5."

%N,'./.'%0B&*5.,(+."-"2%"5.0%Z("5.*+")(5/1%N(="%+/%)*.15%0,%"B&.02("\4"\*2'()%L.1*."

.++()*.2.<" g('" (&,'(" 1.2(=" (+" %+,&2(+" %N/%'*5%0,.*+" 2%" \*2'()%L.1*." 0I(" '%/'(2&T%5"

)(5" %N.,*2I(" (" B&%" ()(''%" 0." \*2'()%L.1*." 2." 0%&'()*+,*)%')(+%" r" %5" C%'.1=" &5."

%6(1&3I("5.*+"*0+*2*(+.<"

" H++*5=" &5" 5(2%1(" %N/%'*5%0,.1" 2%" \*2'()%L.1*." /('" 0%&'()*+,*)%')(+%" /(2%" +%'"

f,*1" 0." )(5/'%%0+I(" 2." L*+*(/.,(1(C*." 2." 2(%03.=" %+/%)*.15%0,%" )(5" '%1.3I(" k+"

*0,%'.3D%+"%0,'%"/.'.+*,."%"\(+/%2%*'("0("%+/.3("1*B&O'*)(<"

" P+,&2(+" %N/%'*5%0,.*+" )(5"!1&'()%*+" ,%'*.5" (" /(,%0)*.1" 2%" L('0%)%'" '%+&1,.2(+"

5.*+"/'ON*5(+"2("B&%"()(''%"0."2(%03."%5"\&5.0(+="/('-5"+%5/'%"+%".)'%2*,(&"B&%"!1&

'()%*+" 0I(" *0L%),." '.,(+" %N/%'*5%0,.1" 7H16.'%T" %," .1<=" #>!>:<" P+,&2(" '%)%0,%" )(0+%C&*&"

*02&T*'"0%&'()*+,*)%')(+%"%5"'.,(+")(5")%/.+"2%"!1&'()%*+"7v%'.+,%C&*"%,".1<="#>!Y:<"g.'."

*++(=" (+" .&,('%+" '%,*'.'.5" (6(+" 2%" /'(C1O,*2%+" 2(" 6%'5%" .2&1,(<" H" +%C&*'=" *02&T*'.5" ."

5.,&'.3I("2%"(0)(+L%'.+"2(+"(6(+"%".+"*0Z%,.'.5"%5"'.,(+<"H/O+"G"5%+%+=")(0+%C&*'.5"

2%5(0+,'.'".1,%'.3D%+"/.,(1OC*).+"%0)%L41*).+<"9(0B&.0,("+%Z."/'(5*++('.=".",-)0*).",%5"

C'.02%")(5/1%N*2.2%"5%,(2(1OC*)."/.'."%N%)&3I(<"H++*5="("&+("2%")%+,(2(+".041(C(+"%"

2%"L4)*1"5.0&,%03I(=")(5(",1&-(0.%"%"!1&-0"''%-#2'="-",.5A-5"f,*1<""

" H" )./.)*2.2%" 2%" 2*+,('3I(" 2%" %+,'&,&'.+" %0)%L41*).+" /('"!1& -0"''%-#2'" /(2%" +%'"

(17)

Yj" +%"/'(1*L%'.5")(5(").)\(+"2%"&6."0("%+/.3("+&A.'.)0O*2%("(&"6%0,'*)&1.'<"$."6%'2.2%=" (" %+,&2(" 2%" a.,(+M8*16." %" )(1.A('.2('%+" 7#>!#:" 6%'*L*)(&" ." ()(''E0)*." 2%" 6%0,'*)&1(5%C.1*.".++*5-,'*)."%5".1C&0+"2%"+%&+".0*5.*+<"

" W+"'%+&1,.2(+"2."/'*5%*'."%,./."2%"0(++(",'.A.1\("5(+,'.'.5"6%0,'*)&1(5%C.1*." )(5" ." *0()&1.3I(" )*+,%'0.1" 2%"!1& -0"''%-#2'<" g('-5" ." 2*1.,.3I(" 2(" +*+,%5." 6%0,'*)&1.'" /(2%'*."+%'"+*5/1%+5%0,%"'%+&1,.2("2."(A+,'&3I("5%)c0*)."2.+"+.b2.+"2%"1bB&('"/%1("pv" 6%0,'b)&1(" (&" .*02." 0(" .B&%2&,(" )%'%A'.1" (&" L('.5%" 2%" a(0'(<" Q5." (A+,'&3I(" *0,%'5*,%0,%"%"/'(C'%++*6."/(2%'*."Z&+,*L*).'"("5.*('"0f5%'("2%".0*5.*+"\*2'()%L41*)(+" .(+" ?" 5%+%+" B&%" 0(" /'*5%*'(" 5E+" /O+M*0()&1.3I(=" A%5" )(5(" &5" 6(1&5%" 6%0,'*)&1.'" +*C0*L*).,*6.5%0,%" 5.*('" .(+" ?" 5%+%+<" g('" (&,'(" 1.2(=" %+,." %6(1&3I(" 5.*+" .''.+,.2." ,.5A-5"/(2%'*."+%"2%6%'"."&5")(5/(0%0,%"*0L1.5.,O'*(<"

" $."+%C&02."%,./."2(",'.A.1\(="6%'*L*).5(+"*0L*1,'.2(+"*0L1.5.,O'*(+"0("%/E02*5." %" 0(" /1%N(" )('O*2%<" H" %/%02*5*,%" -" &5" .)\.2(" *0,'.(/%'.,O'*(" A%5" )(0\%)*2(" 0." \*2'()%L.1*."/('"0%&'()*+,*)%')(+%"7g'(.]("%,".1<=""#>>^:<"W+"%+,&2(+"2%"H16.'%T"%"i%.1%" ,.5A-5" 5(+,'.'.5" (" %/E02*5." )(5(" &5." 6*." *5/(',.0,%" 2%" *0L*1,'.3I(" 1%&)()*,4'*." /.'." (+" %+/.3(+" 1*B&O'*)(+" 7H16.'%T" %" i%.1%=" #>>j:<" P5" 0(++(" 5(2%1(=" ." '&/,&'." 2(" %/E02*5." /%1." /'O/'*." \*2'()%L.1*." /(2%'*." L.)*1*,.'" ." *0L*1,'.3I(" 2%" 1%&)O)*,(+" /.'." ." ).6*2.2%" 6%0,'*)&1.'<" g('" (&,'(" 1.2(=" 0(" 5(2%1(" %N/%'*5%0,.1" 2%" 0%&'()*+,*)%')(+%" %5" ).5&02(0C(+")(5",1&-(0.%="("/1%N(")('O*2%"0I("-"&5"+b,*("*5/(',.0,%"2%"*0L*1,'.3I("2%" 1%&)O)*,(=" )(0B&.0,(" (" +%Z." %5" )-'%A'(+" 0('5.*+" 7H16.'%T" %" i%.1%=" #>>`:" %" 0(" B&%" (A+%'6.5(+"0("5(2%1("('."2%+%06(16*2(<"

(18)

Y_" " H+" .1,%'.3D%+" /.,(1OC*).+" (A+%'6.2.+" %5" 0(++(" 5(2%1(" %+,I(" 2%" .)('2(" )(5" ("

B&%"+%"(A+%'6."0."\*2'()%L.1*."%N/%'*5%0,.1"%5"C%'.1="(&"+%Z.="'&/,&'."%".2%1C.3.5%0,("

2(" %/*,-1*(" %/%02*54'*(=" %2%5." 2(" /1%N(" )('O*2%" %" /'(1*L%'.3I(" .+,'(C1*.1"

/'*0)*/.15%0,%"0."'%C*I("/%'*6%0,'*)&1.'"7e%1"n*C*(="!^^?:<"

" H1,%'.3D%+" )(5/(',.5%0,.*+" 2(+" .0*5.*+" +I(" A%5" 2()&5%0,.2.+" 0(+" 5(2%1(+"

%N/%'*5%0,.*+" 2%" \*2'()%L.1*." 7J(/%+" %," .1<=" #>>^V" W1(/.2%" %," .1<=" #>!#:<" P5" 0(++("

5(2%1(="%5A('."0I(",%0\.5(+"L%*,("&5.".041*+%"+*+,%54,*)."2(+".0*5.*+="0I("0(,.5(+"

.2(%)*5%0,("0%5".1,%'.3D%+"+*C0*L*).,*6.+"+%&")(5/(',.5%0,(<"p++("/(2%"+%'"%N/1*).2("

/%1." %6(1&3I(" 1%0,." 2." 2*1.,.3I(" 6%0,'*)&1.'=" (" B&%" /%'5*,*'*." .(+" .0*5.*+" ." .2(3I(" 2%"

5%).0*+5(+")(5/%0+.,O'*(+<"

" h%)%0,%5%0,%" ,%5M+%" %+,&2.2(" (" /./%1" 2." .B&./('*0.MG" 7HzgMG:=" &5" ).0.1" 2%"

4C&.=" )(5(" 6*." .1,%'0.,*6." /.'." .A+('3I(" 2%" 1bB&('<" P5" .0*5.*+" )(5" \*2'()%L.1*." \4"

.&5%0,("2."%N/'%++I("2."HzgMG"0."5%5A'.0."A.+(1.,%'.1"2%")-1&1.+"2("%/E02*5."%"0(+"

/-+" 6.+)&1.'%+" 2(+" .+,'O)*,(+" 7Wo1%'" %," .1<=" #>!>:<" P++." %N/'%++I(" .&5%0,.2." +%"

)(''%1.)*(0." )(5" 4'%.+" 2%" .1,%'.3I(" 2(" )(%L*)*%0,%" 2%" 2*L&+I(" ./.'%0,%" 2%" 4C&." %5"

%+,&2(+" )(5" '%++(0c0)*." 5.C0-,*)." 78UZ(12*0C" %," .1<=" #>!>:<" z&.02(" +&A5%,*2(+" k"

*0Z%3I(" )*+,%'0.1" 2%" ).&1*5=" .0*5.*+" )(5" 2%L*)*E0)*." 0." %N/'%++I(" 2%" HzgMG" ,E5"

\*2'()%L.1*." 2%" *0+,.1.3I(" 5.*+" '4/*2." 7n1()\" %," .1<=" #>>`:<" z&%+,*(0.5(+" +%" %5" 0(++("

5(2%1(=")(5"&5."\*2'()%L.1*."2%"%6(1&3I("5.*+"1%0,.="."HzgMG"/(2%",%'"&5"/.2'I("2%"

%N/'%++I("2*L%'%0,%"2("B&%"+%",%5"'%/(',.2("0."1*,%'.,&'.<"

" W&,'(++*5"0(++("5(2%1(".A'%"/%'+/%),*6.+"/.'."("%+,&2("2."\*2'()%L.1*.")'q0*).<"

$(")14++*)("5(2%1(")(5").&1*5="."\*2'()%L.1*."+%"*0+,.1."'./*2.5%0,%="("B&%"0I("()(''%"

%5",(2.+".+"L('5.+"2%"\*2'()%L.1*."%5"\&5.0(+<"H"%6(1&3I("'4/*2."2."\*2'()%L.1*."/('"

).&1*5" 1*5*,." ." /(++*A*1*2.2%" 2%" %+,&24M1." ." 1(0C(" /'.T(=" \.Z." 6*+,." (" .2(%)*5%0,(" 2(+"

(19)

Y^" g.'." )(0,('0.'" %+,%" /'(A1%5.=" e%1" n*C*(" /'(2&T*&" &5" 5(2%1(" 2%" \*2'()%L.1*." 2%" %6(1&3I(" .''.+,.2." ." /.',*'" 2%" /%B&%0.+" 2(+%+" 2%" ).&1*5" %5" '.,(+" )(5" ?" +%5.0.+" 2%" 6*2."%"B&%"L('.5"5.0,*2(+"6*6(+"/('"^"5%+%+"./O+"."*0()&1.3I(<"8%&+"'%+&1,.2(+"L('.5" +%5%1\.0,%+".("B&%"()(''%"%5"\&5.0(+"%5",%'5(+"2%"1%+I("2%"+&A+,c0)*."A'.0)."7e%1" n*C*(" %," .1<=" #>>?:<" d4" B&%" +%" 0(,.'=" /('-5=" B&%" ." *02&3I(" 2." \*2'()%L.1*." ()(''%&" %5" .0*5.*+" .(6%0+<" $%++%" +%0,*2(=" .&+,*L*).M+%" &5" 5(2%1(" %N/%'*5%0,.1" 2%" \*2'()%L.1*." %5" .0*5.*+".2&1,(+<"

" "

P%+%."AB#'&/(&.0"5"):(&

"" W" 0f5%'(" 2%" .0*5.*+" L(*" /%B&%0(" /.'." %+,.A%1%)%'" 5.*+" )(5/.'.3D%+" %0,'%" C'&/(+=" %+/%)*.15%0,%" )(5" ." *0.%3I(" 2%" ).&1*5<" g('-5" (" 0f5%'(" 2%" .0*5.*+" )(5" *0()&1.3I(" 2%" !1& -0"''%-#2'" L(*" +&L*)*%0,%" /.'." (A+%'6.'" .+" .1,%'.3D%+" 2%+%..2.+=" /'*0)*/.15%0,%"."2*1.,.3I("6%0,'*)&1.'<"

" $I(" '%.1*T.5(+" &5." .6.1*.3I(" +*+,%54,*)." 2(" )(5/(',.5%0,(" 2(+" .0*5.*+<" H" (A+%'6.3I(" 2%" B&%" 0I(" +(L'%'.5" .1,%'.3D%+" +*C0*L*).,*6.+" -" +&A.%,*6." %" 2%6%" +%'" )(5/'(6.2."%5"%+,&2(+"/(+,%'*('%+"

" z&%+,*(0.M+%" ,.5A-5" (" /./%1" 2%" )(5/(0%0,%+" *0L1.5.,O'*(+" /'%+%0,%+" 0." ).6*2.2%" /%'*,(0%.1" 2(+" ).5&02(0C(+" (02%" +%" 5.0,*6%'.5" (+" )*+,(+" 2%"!1& -0"''%-#2'<" P6%0,&.15%0,%"(+"2%A'*+"*0L1.5.,O'*(+"/%'*,(0%.*+"2%").5&02(0C(+"/(2%5",%'".1C&5." *0L1&E0)*."0."'%+/(+,."*0L1.5.,O'*."*0,'.)'.0*.0."2(+"'.,(+<"

" H"6.'*.A*1*2.2%"2."\*2'()%L.1*."*02&T*2."/%1(").&1*5"%5"0(++(+".0*5.*+",.5A-5" -" 2*C0." 2%" 0(,.=" %5A('." .1C&0+" %+,&2(+" 5%0)*(0%5" B&%=" 2%" L.,(=" ." '%+/(+,." .(" ).&1*5" )*+,%'0.1"0%5"+%5/'%"+%.."\(5(CE0%."78\.(1*0"%,".1<="#>!Y:<"

(20)

`>" .1,%'.3D%+"2%,%),.2.+"L('.5"+&L*)*%0,%+"/.'."2%,%'5*0.'"."()(''E0)*."2%"\*2'()%L.1*."%"."

5%0+&'.3I("2("6(1&5%"6%0,'*)&1.'<"

" 9(5" '%1.3I(" k" .041*+%" \*+,(1OC*).=" 0I(" B&.0,*L*).5(+" ." *0,%0+*2.2%" 2." '%+/(+,."

*0L1.5.,O'*." %5" ).2." .0*5.1<" H" .041*+%" ,.5A-5" +%" '%+,'*0C*&" k" )(1('.3I(" )(5"

\%5.,(N*1*0." %" %(+*0.<" W&,'.+" )(1('.3D%+" %" ,-)0*).+=" )(5(" *5&0(*+,(B&b5*).="

.)'%+)%0,.'*.5"*0L('5.3D%+")(5"'%1.3I("k+".1,%'.3D%+"*0L1.5.,O'*.+=".+,'(C1*(+%"'%.,*6."

%"/%'2."2%"5*%1*0."0."+&A+,c0)*."A'.0).<"

" i.5A-5" 0I(" %+,&2.5(+" .1,%'.3D%+" 1*B&O'*).+<" 8.A%M+%" B&%" 0." 0%&'()*+,*)%')(+%"

%N,'./.'%0B&*5.,(+." \4" .1,%'.3D%+" 2%" 1bB&('" )(5(" \*/(C1*)(''.B&*.="

\*/%'/'(,%*0(''.B&*.=".&5%0,("2%"1%&)O)*,(+"%"%(+*0(L*1*.<"W"%0)(0,'("2%++.+".1,%'.3D%+"

%5"0(++("5(2%1(")(''(A('.'*."."\*/O,%+%"2%"\.6%'"&5")(5/(0%0,%"*0L1.5.,O'*(")(5("

).&+."2."\*2'()%L.1*.<"

" ;*0.15%0,%=" ./%+.'" 2.+" +%5%1\.03.+" L*1(C%0-,*).+" %0,'%"!1&-0"''%-#2'&%"!1&'()%*+="

.+" '%.3D%+" *5&0(1OC*).+" %" *0L1.5.,O'*.+" 2%+%0).2%.2.+" /('" ).2." &5" 2%6%5" +%'"

2*L%'%0,%+<" H1-5" 2(" 5.*+=" ." *0()&1.3I(" 2(+" )*+,(+" 2*'%,.5%0,%" 0(" +*+,%5." 0%'6(+("

)%0,'.1" 0I(" '%/'%+%0,." (" 5%+5(" /'()%++(" 2%" .,*6.3I(" 2(+" )*+,(+" 2%"!1& '()%*+&" %5" +&."

/.++.C%5"/%1(",'.,("C.+,'(*0,%+,*0.1<"

(21)

(22)

`#"

D%"9;'6R.6_"

! H" *0()&1.3I(" )*+,%'0.1" 2%" )*+,(+" 2%"!1&-0"''%-#2'" *02&T" \*2'()%L.1*." %N/%'*5%0,.1"

%5"'.,(+V"

! H" \*2'()%L.1*." *02&T*2." /%1." *0()&1.3I(" 2%"!1&-0"''%-#2'" %5" '.,(+" 2%+%06(16%M+%"

1%0,."%"/'(C'%++*6.5%0,%V"

! $%+,%" 5(2%1(=" ." \*2'()%L.1*." /.'%)%" +%'" 2%6*2." ." &5." )(5A*0.3I(" 2%" (A+,'&3I("

5%)c0*)."%"*0L1.5.3I(<"

(23)

(24)

`G" 4.=.$S"92,6*

9):3)#&'")7)";63$2,'3$#2(2,'25)62,'6&,'2"#$%&,')6+$2(&,'52"2'5./<$32=-&>'

'

H16.'%T" sp=" a*+\'." nn=" [&02'." Qa=" a*+\'." gS=" i%.1%" sa<" a%+()%+,(*2%+" )(',*" *0,'.)'.0*.1" *0L%),*(0".+"."5&'*0%"5(2%1"L('"0%&'()F+,*)%')(+*+<"g.'.+*,(1(CF"#>!>V"!?jl?Y^Mj#<"

H16.'%T"sp="i%.1%"sa<"n'%.U2(o0"(L",\%"A1((2"A'.*0"A.''*%'".02"A1((2r)%'%A'(+/*0.1"L1&*2"A.''*%'" *+" .++()*.,%2" o*,\" 2*LL%'%0,*.1" 1%&U()F,%" 5*C'.,*(0" *0" 2*+,*0)," )(5/.',5%0,+" (L" ,\%" 9$8" 2&'*0C" ,\%")(&'+%"(L"5&'*0%"$99<"s"$%&'(*55&0(1"#>>`V"!j?lGYMYY<"

H16.'%T"sp="i%.1%"sa<"P6*2%0)%"L('"2*LL%'%0,*.1")\.0C%+"(L"Z&0),*(0.1")(5/1%N"/'(,%*0+"*0"5&'*0%" 0%&'()F+,*)%')(+*+"2%/%02%0,%"&/(0"9$8"6.+)&1.,&'%<"n'.*0"h%+<"#>>jV"!!`^l^_M!!!<"

H16.'%T" sp=" i%.1%" sa<" a&1,*/1%" %N/'%++*(0" (L" 5.,'*N" 5%,.1(/'(,%*0.+%+" *0" 5&'*0%" 0%&'()F+,*)%')(+*+l" *5/1*).,*(0+" L('" 1%&U()F,%" 5*C'.,*(0" ,\'(&C\" 5&1,*/1%" )%0,'.1" 0%'6(&+" +F+,%5"A.''*%'+<"n'.*0"h%+<"#>>_V"!#!Gl!GYM!Y_<"

n1()\" W=" H&C&+,%" Sp=" a.01%F" [i=" v%'U5.0" H8<" H))%1%'.,%2" /'(C'%++*(0" (L" U.(1*0M*02&)%2" \F2'()%/\.1&+"*0".B&./('*0MGM2%L*)*%0,"5*)%<"s"9%'%A"n1((2";1(o"a%,.A(1"#>>`V"#`l!Y#jM!Y?j<" 9.'2(0." HP=" h%+,'%/(" np=" s.'.5*11(" sa=" i%.1%" sa<" e%6%1(/5%0," (L" .0" .0*5.1" 5(2%1" L('" 0%&'()F+,*)%')(+*+l"*5&0%"'%+/(0+%"*+")\.'.),%'*T%2"AF"."/'%2(5*0.0)%"(L""ÇÉ"i")%11+<"s"p55&0(1<" !^^^V"!`#l^^YM!>>#<"

9.'/*(" H=" ;1%&'F" H=" d.&+%'" RH<" $%&'()F+,*)%')(+*+l" L*6%" 0%o" ,\*0C+<" $%&'(1" 91*0" g'.),<" #>!?V" ?l!!_M!#Y<"

9(11*"nW="9.'1(,,*"s'"9[="H++*'.,*"s'"sH="a.)\.2("dh="v.1%03."a="H5.,("a9a<"8&'C*).1",'%.,5%0,"(L" )%'%A'.1")F+,*)%')(+*l"1(0CM,%'5"'%+&1,+".02"/'(C0(+,*)"L.),('+<"$%&'(+&'C";()&+"#>>#V"!#l?<" 9(F1%" 9a=" a.\.0,F" 8=" m&0," sh=" R.11*0" ai=" 9.0,%F" gi=" R\*,%" s'" H9=" %," .1<" $%&'()F+,*)%')(+*+l" 0%C1%),%2"A&,"0(,"L('C(,,%0<"gn(8"$%C1"i'(/"e*+<"#>!#V"`l%!Y>><"

9(F1%"9a<"$%&'()F+,*)%')(+*+l".0"&/2.,%<"9&''"p0L%),"e*+"h%/<"#>!GV"!`lG?j<"

e.02F" RP=" n1).)UL.0" Se<" p0,%'0.1" \F2'()%/\.1&+<" H0" %N/%'*5%0,.1=" )1*0*).1" .02" /.,\(1(C*).1" +,&2F<"H5%'"s"e*+"9\*12"!^!GV"_lG>`MG_#<"

(25)

`Y"

e%1" n*C*(" ah<" $%&'(/.,\(1(C*).1" )\.0C%+" ).&+%2" AF" \F2'()%/\.1&+<" H),." $%&'(/.,\(1" !^^?V"

_YlYj?MY_Y<"

e%1"n*C*("ah="R*1+(0"as="P00("i<"9\'(0*)"\F2'()%/\.1&+"*0"'.,+".02"\&5.0+l"o\*,%"5.,,%'"1(++"

.02"A%\.6*('")\.0C%+<"H00"$%&'(1"#>>?V"Y?l??jM?G`<"

P+,.](1" n=" 9('(0." i=" HA.2" g<" H" /'(C0(+,*)" )1.++*L*).,*(0" (L" )%'%A'.1" )F+,*)%')(+*+l" ,\%'./%&,*)" *5/1*).,*(0+<"s"$%&'(1"$%&'(+&'C"g+F)\*.,'F"!^_`V"G^l"!!?!M!!?G<"

;1*++%'" H=" 8.',*" P=" J*C\,(o1%'+" a=" 8)\.0,T" g<" $%&'()F+,*)%')(+*+l" '%C*(0.1" +,.,&+=" %/*2%5*(1(CF="

*5/.),".02")(0,'(1"5%.+&'%+"*0",\%"H5%'*).+<"H),."i'(/*)."#>>?V"_jlG?MY!<"

[.')b."dd="P6.0+"HR="$.+\"iP="i.U.F.0.C&*"Wa="R\*,%"s'"H9="n(,%'("e="%,".1<"9&''%0,")(0+%0+&+"

C&*2%1*0%+"L('",'%.,5%0,"(L"0%&'()F+,*)%')(+*+<"91*0"a*)'(A*(1"h%6<"#>>#V"!YljGjMjY`<"

[.')*." dd=" $.+\" iP=" e%1" n'&,,(" Wd<" 91*0*).1" +F5/,(5+=" 2*.C0(+*+" .02" ,'%.,5%0," (L"

0%&'()F+,*)%')(+*+<"J.0)%,"$%&'(1<"#>!GV"!?l!#>#M!#!Y<"

d()\o.12"[a<"H0*5.1"5(2%1+"(L"\F2'()%/\.1&+l"'%)%0,%"2%6%1(/5%0,+<"g'()"8()"PN/"n*(1"a%2"

!^_YV"!j_l!M!!<"

S%11%F"h="e&(0C"ed="J()U%"[P<"9\.'.),%'*+,*)+"(L"6%0,'*)&1.'"+\&0,"5.1L&0),*(0+".5(0+"/.,*%0,+"

o*,\"0%&'()F+,*)%')(+*+<"$%&'(+&'C%'F"#>>#V"Y>ljYjMj`#<"

J(/%+"J8="81(A(2*.0"p="e%1"n*C*("ah<"9\.'.),%'*T.,*(0"(L"Z&6%0*1%".02"F(&0C".2&1,"5*)%"L(11(o*0C"

*02&),*(0"(L"\F2'()%/\.1&+"o*,\"U.(1*0<"PN/"$%&'(1"#>>^V"#!^l!_jM!^`<"

a.\.1%" hh=" a%\,." H=" h.0C.+%,,F" 8<" PN,'./.'%0)\F5.1" 7'.)%5(+%:" 0%&'()F+,*)%')(+*+" .02" *,+"

5&1,*,&2%"5.0*L%+,.,*(0+l".")(5/'%\%0+*6%"'%6*%o<"s"91*0"$%&'(1<"#>!YV"!!l#>?M#!!<"

a.,(+M8*16."d="h%)*/&,,*"ng="2%"g.&1."P9="W1*6%*'."HJ="a(&'."vnJ="v*0.&2"a9="%,".1<"PN/%'*5%0,.1"

%0)%/\.1*,*+" ).&+%2" AF" i.%0*." )'.++*)%/+" )F+,*)%')*" *0" 5*)%<" H'B" $%&'(/+*B&*.,'" #>!#V" j>l#_jM

#^#<"

a.,&+\*,." d=" g*0,(" ;9[=" 9.'2%.1" ee=" i%*N%*'." as<" dF2'()%/\.1&+" *0" 0%&'()F+,*)%')(+*+<" 9\*12+"

$%'6"8F+,<"#>!!V"#jl!j>^M!j#!<"

a(&,(0=" g<h<=" #>!G<" $%&'(+,%'%(1(CFl" Q0A*.+%2" 8,%'%(1(CF" (L" $%&'.1" 8F+,%5+=" L*'+," %2<" R*1%FM

(26)

``"

$.+\" iP=" 8*0C\" ae=" R\*,%" H9=" h.Z+\%U\.'" v=" J(%A" sH=" g'(.](" sv=" %," .1<" i'%.,5%0," (L"

0%&'()F+,*)%')(+*+l")&''%0,"+,.,&+".02"L&,&'%"'%+%.')\"0%%2+<"$%&'(1(CF"#>>`V"`jl!!#>M!!#j<"

WX$%.1" 8P=" ;1%)U%'" hd<" d(+/*,.1*T.,*(0" L'%B&%0)F" .02" )\.'C%+" L('" 0%&'()F+,*)%')(+*+=" Q0*,%2"

8,.,%+="#>>?M#>!#<"P5%'C"p0L%),"e*+<"#>!YV"#!l^`^M^j`<"

W1(/.2%" ;P=" 8\(U&0A*" ai=" 8*'-0" HJ<" i\%" '%1.,*(0+\*/" A%,o%%0" 6%0,'*)&1.'" 2*1.,.,*(0="

0%&'(/.,\(1(C*).1" .02" 0%&'(A%\.6*(&'.1" )\.0C%+" *0" \F2'()%/\.1*)" '.,+<" ;1&*2+" n.''*%'+" 9$8"

#>!#l^l!^<"

Wo1%'" nS=" g*,\.5" i=" R.0C" e<" HB&./('*0+l" '%1%6.0)%" ,(" )%'%A'(+/*0.1" L1&*2" /\F+*(1(CF" .02"

,\%'./%&,*)"/(,%0,*.1"*0"\F2'()%/\.1&+<"9%'%A'(+/*0.1";1&*2"h%+"#>!>V"jl!Y<"

g'(.](" sv=" i(''%+M9('T(" s=" h(2'bC&%+Me.11." v%))\*." h<" [&*T.'M8.\.C&0" [=" h.0C%1M9.+,*11." J<"

p0,'.6%0,'*)&1.'" .02" +&A.'.)\0(*2.1" A.+.1" )*+,%'0+" 0%&'()F+,*)%')(+*+l" ." )(5/.'.,*6%" +,&2F"

A%,o%%0" ,'.2*,*(0.1" ,'%.,5%0," 6%'+&+" 0%&'(%02(+)(/*)" +&'C%'F<" 9\*12+" $%'6" 8F+," #>>^V"

#Yl!G`jM!GjY<"

h.0C%1M9.+,*11."J="8%'/."sH="[(/*0.,\"8g="['.6*++"PH="e*.TMa.')\.0"g="R\*,%"s'"H9<"9(0,%5/('.'F"

0%&'(+&'C*).1".//'(.)\%+",("0%&'()F+,*)%')(+*+<"H5"s"i'(/"a%2"dFC<"#>>^V"_>l?j?M?j_<"

8\.(1*0"m="m\.0N*.0C"R="d.("{=";%*L%*"m="9.*B&.0"d="e(0C\.0"9"%,".1<"dF2'()%/\.1&+"*02&)%2"6*."

*0,'.6%0,'*)&1.'"U.(1*0"*0Z%),*(0"*0".2&1,"'.,+<";(1*."$%&'(/.,\(1"#>!YV"Y?l`>M`_<"

8UZ(12*0C"He="h(o1.02"ps="8(C..'2"Jv="g'.%,('*&+"s="g%0U(o."a="s&\1%'"a<"dF2'()%/\.1&+"*02&)%+"

2F0.5*)+" +/.,*(,%5/('.1" '%C&1.,*(0" (L" .B&./('*0MG" %N/'%++*(0" *0" ,\%" '.," A'.*0<" 9%'%A'(+/*0.1"

;1&*2"h%+"#>!>V"jl#><"

v%'.+,%C&*" ah=" a%Z*." H=" 91.'U" i=" [.6*2*." 9a=" a.5.0*" s=" 9)(/." ;=" %," .1<" $(6%1" '.," 5(2%1" L('"

0%&'()F+,*)%')(+*+"&+*0C"i.%0*."+(1*&5<"H5"s"g.,\(1"#>!YV"!_Yl##Y^M##`_<"

R.11*0"ai="S&',TU%"s;<"$%&'()F+,*)%')(+*+"*0",\%"Q0*,%2"8,.,%+l"'%6*%o"(L".0"*5/(',.0,"%5%'C*0C"

*0L%),*(0<"$%&'(1(CF"#>>GV"`?l!YY^r!Y`G<"

R*115+" S=" m&'.A*.0" h<" i.%0*." )'.++*)%/+l" *0" 6*6(" .02" *0" 6*,'(" 5(2%1+<" g.'.+*,(1(CF" #>!>V"

!?jl??YM?G`<"

(27)

`j"