Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway.

When EZH2 protein expression was significantly down-regulated by treatment with EZH2 siRNA the signal- ing proteins of the PI3K/Akt/mTOR pathway also showed a significant reduction

Constitutive activation of the PI3K/Akt pathway was demonstrated in T-ALL cell lines and our own data indicate that it is highly frequent in primary leukemia cells.. This

Another investigation also demonstrated that inhibition of PI3K/Akt signaling by Cbl (Cbl-b and c-Cbl) may be involved in both ATO-induced apoptosis of NB4 cells and ATO-induced

Hence, we have demonstrated the anti-cancer mechanism for MBT-induced cell cycle arrest and autophagy in HXO- RB44 cells to be through inhibition of PI3K/Akt signaling

umbella- tum is cytotoxic to human leukemia cells, promoting cell growth inhibition and inducing death via apoptosis by an increase in ROS generation, alterations in mitochondrial

O principal objectivo é ficar a conhecer melhor esta vertente do sofrimento, o seu real impacto, para que os profissionais de saúde ao ficarem mais sensibilizados para este

Assentamentos, variando a percentagem de compactação do aterro técnico Os gráficos seguintes representam a interacção solo – laje de transição e ilustram o resultado obtido

To analyze the role of mTOR in the autophagy induced by LA, we analyzed the phosphorylation of mTOR and its target S6 ribosomal protein by WB in SH-SY5Y cell line using