• Nenhum resultado encontrado

HIV infection and the kidneys, Part I

N/A
N/A
Protected

Academic year: 2017

Share "HIV infection and the kidneys, Part I"

Copied!
4
0
0

Texto

(1)

PREGLEDI IZ LITERAT URE

ЬЦѬЧќйЬфѳїЬѭдяѯѸѨдѸѳЦЧЬѸдЦѯЭЧѬЬйЬфЧЦйЬфЧ

ЬѻдѻѭЧє

I

DEO)

·Î¿ÃÑÒÑÍȳ¦È¬ÆºÈšÆº©

Institut za patologiju, Medicinski fakultet, Univerzitet u Beogradu, Beograd

ƭƳƢƵƢƭƴƢƧƳƩƢNJ

ƭǠǖǒǠǝǗǣǟǚǜǑǚǟǦǚǨǚǢǑǟǚǧǓǚǢǥǣǠǞǧǥǞǑǟǗǚǞǥǟǠǖǗǦǚǨǚǹǗǟǨǚǹǗ HIVǜǝǚǟǚǩǜǚǣǗǞǠǘǗǚǣǡǠǺǚǤǚǪǚǢǠǜǣǡǗǜǤǑǢ ǣǚǞǡǤǠǞǑǜǠǹǚǥǜǑǙǥǹǥǟǑǠǪǤǗǼǗǻǗǒǥǒǢǗǔǑưǑǹǩǗǪǼǗǣǗǹǑǓǺǑǑǜǥǤǟǑǚǟǣǥǦǚǨǚǹǗǟǨǚǹǑǢǑǖǑǒǥǒǢǗǔǑǜǠǹǑǹǗǠǒǚǩǟǠǡǠǣǝǗ ǖǚǨǑǣǗǡǣǗǧǚǡǠǤǗǟǙǚǹǗǚǝǚǟǗǦǢǠǤǠǜǣǚǩǟǚǧǑǔǗǟǣǑƲǠǢǗǖǑǜǥǤǟǗǚǟǣǥǦǚǨǚǹǗǟǨǚǹǗǢǑǖǑǒǥǒǢǗǔǑǜǠǖǚǙǓǗǣǟǠǔǒǢǠǹǑǒǠǝǗ ǣǟǚǜǑǹǑǓǺǑǣǗǟǗǦǢǠǡǑǤǚǹǑǚǙǑǙǓǑǟǑǣHIVǜǠǹǑǹǗǣǜǝǗǢǠǙǚǢǑǹǥǼǗǡǢǚǢǠǖǗǚǣǞǑǤǢǑǣǗǠǒǝǚǜǠǞǦǠǜǥǣǟǠǣǗǔǞǗǟǤǟǗǔǝǠǞǗǢǥ ǝǠǣǜǝǗǢǠǙǗǜǠǹǑǚǞǑǟǑǹǡǢǠǔǢǗǣǚǓǟǚǹǚǤǠǜ

ƭǺǥǩǟǗǢǗǩǚHIVǟǗǦǢǠǡǑǤǚǹǑǚǙǑǙǓǑǟǑǣHIVǦǠǜǥǣǟǠǣǗǔǞǗǟǤǟǑǔǝǠǞǗǢǥǝǠǣǜǝǗǢǠǙǑǑǜǥǤǟǑǚǟǣǥǦǚǨǚǹǗǟǨǚǹǑǒǥǒǢǗǔǑ

UVOD

ÇδœÊ»Î§ÎÀѧÜÀœÊ¨ª²ÎèÒÑԜ»Ñ»ÑÃѵœ¶ ÀԜʶξœ¸ÎÃÑ œÒÑÉÑÒܧ¨µÑ¨Ò֜»®¨µœÔ¨¿¶ÀΧª¶

§ÑҜ¨§¶ÒÎÜ֨®¨µœÒ®¨µœ HIV´¨Ò¨¸ÎÀœÃѾ¨¾¶

¾¿œ²»ÎÃÎÀξÑξθœ¸¨ªÎÃÀ¨Ãœ§Î²Ñξ¨Ê¨Éμʜ ±œÒ˜±¶Ê¨§²ÎèҜξµÑÔ¹œÒµœÉ¿Ô¨¿Ñö »Î§œÀœ»ÎÃÎÔ¨ª¾Î¸œÀÒ¨»ÑÎɨÀ¶µ¶¨É¿Î§œÒœÒѾ¶ ¾¿œÓ¨§Ñ£¿ÑÃÎÔ¨§Ñ»Îµ¨À¶À¸œÃ¨¸¨ÎɨÀÑÒµœ´¨ÊÑÔ Àɜ»ÊѿɿלÒѻεœÀ¶¶ÊÔ¿±œÒœ»ÎþθœÀÒ¨»Ñ»ÎÃ

»Îµ¨ªµœ¾¨¸ÑÉÎÊÔ¿±œÒÑHIV¨Ò֜»®¨µÑ#%¦Ñ»ÎÀ¶

kao posledicaHIV¨Ò֜»®¨µœÒѾ¶¾¿œÓ¨§ÑÎɨÀÑÒ¨

Ñ»¶ÊÒÑʶ¾¶¸À»ÑҜ»¿ÎÓѻεѧÎÁœÒÑÀÊÑʨ»ÑÎÉÎ À¸œÃ¨®Ñª¨ÉÎʜÒÓ¨µœÃœª¨Ã¿ÑÊÑ®¨µœÊµª¨ÉÎÔ蜧¨µ À»Î²¼Î»ÑÀœÉÀœ¿ÑèλÎÒÊ¿ÑÀÊÒ¨ªÑ²œÒÀѻε¨Àœ»Î ¿¨Àʜ¶Ã¨µÑ²ÒÎÀʨ´»œÀÔ¿ªœ¨¸¨Àœ§ÎÁœ¿ÑÓԨʨ»ÑÎ ÉÎÀ¸œÃ¨®ÑÉ¿¨§œÒœÒœÖ¿ÎÊλÀ¨´Ò¨ª¸œ»ÎÔÑ#% alergijski intersticijski nefritis, koji nastaje ¶À¸œÃÉ¿¨§œÒœ¸œ»ÎÔѻε¨Àœ»Î¿¨Àʜ¶¸œ´œ ¶À¨Ãœ »ÑμÊÎÀ¶Ê¿¨§œÊÎÉ¿¨§À¶¸ÖѧœÊλÀÑÓθҜֿΠ»Ñ¸®¨ÒÎÓѻѿ®¨ÒΧ¿œÒѸҨª¤œ¸¨µÑ»¿¨ÉÊÎ »Î»Ò¨ÑÉÀ®œÀ¨¿ÑÓ¸¨´¨ÊœÉ¿Î§œÒœÒѲ¸Î§œ¿¶¸¨ §Ñº¨¼œ²Î輠ѨÀɨʨÔÑ ÑÀ¶ÉλÑÓѸÑÃѶÀ»¸Î ɶÀ¨Ãœ»ÎþθœÀÒ¨»ÑÃθÑÓ¨ÃÎμʜ¤œ Ñ¾¶ ¾¿œ²Ñ»ÎµœÀœ¨ÀÉιÑÔÑ»ÑÎҜֿÎÉÑʨµÑ¨ÓÑÓÔÑÒÑÀ

HIV#%»ÎµÑÔÑÊÑѸœ¿²¨µÀ»¨¨Òʜ¿Àʨ®¨µÀ»¨

Ҝֿ¨Ê¨À ¨ÓÑÓÔÑÒÉ¿¨§œÒΧ¸œ»ÎÔѨ§¶ÒλΧɸœ» ÀÒ¨²¸Î§œ¿¶¸ÎҜֿ¨Ê¨À¨Öλ¶ÀÒÎÀœ²§œÒÊÒ¶²¸Î§œ ¿¶¸ÎÀ»¸œ¿ÎÓ¶ÀɨʨÔÑ ÑÀ¶ÉλÑÓѸÑÃÑҜÉÎÀÊÎ µ¨»Î¿œ¸Ñ®¨µÑ¨Ó§œ±¶¿ÑÓÔεÑҜֿÎÉÑʨµœ¨ÓÑÓÔÑҜÀ

HIVÀÊÑ¿ÎÀʨξθœ¸¨ªÎÀξÑʿѵѠÑHIV¨Ò֜»®¨

µœ¨¸¨Ê¨ÉÑÎÉοʶҨÀʨ´»œ¨Ò֜»®¨µœ#%

ЦЧѬѭѯѱѳлЬфѳЬьѳьїѳЦѳяHIV

£¾¿ÎµÒ¨§¿ÑÃÎÔ¨§ÑÎɨÀÑҜÀ¶»¸¨Ò¨´»œ§ÑÒ¨ ֜ÀÊÑ®¨µœ»ÎµœÀœµÑԹѵ¶»ÎþθœÀÒ¨»ÑÀ»¸ÑÀ¨´ÒΧ nefropatijom izazvanom sHIV#%£ÀÔ¨§¨À

Ê¿ÑÁ¨ÔÑ ¨§Ñ¾Î¸œÀÒ¨»ÑÀÎÔ¨§Î¾Î¹œ œ§Ê¨É¨´Òœ À¶É¿Îʜ¨Ò¶¿¨µÑ »ÎµÑ´œÀÊÎÃÎÀʨÁœÔœ¸¨»œÔ¿œÃÒÎ Àʨ¨¨ÒÀ¶Ö¨®¨µœÒ®¨µÑ¿ÑÃѾ¶¾¿œ²Ñ°ÑÒ¨§¹¨Ôεœ ÃÑÀœ»ÎþθœÀÒ¨»Ñ»Îû娪Àœ¿ÑÓÔ¨µœÒœÖ¿ÎÊÀ»¨ À¨ÒÿΧ¿œÊ»Î¶ÊÔ¿±¶µ¶ª¨Éœ¿ªÎ¸œÀʜ¿Î¸œ§¨µÑ¨²œ

Ҝ¿Ñ¸¨ÓÎÔÑÒ¨ÎÊή¨#%¼ÊÎÀœÊ¶§Ñ´¨À§Ñ œ œ§ À¨ÒʜӜ¸¨ÉÎÉ¿Îʜ¨ÒѶµœÊ¿¨»ÎµœÀœµÑԹѶÀ»¸Îɶ

HIV¨Ò֜»®¨µœ£¸¨Êœ¿Ñʶ¿¨ÉÎÀÊεœ¿ÑÓ¸¨´¨Ê¨ÉÎ

ÃÑ®¨Î¶´œÀÊѸÎÀʨµÑԹѠѪ¨Éœ¿ÊœÒÓ¨µœ»Îþθœ snika s nefropatijom izazvanom sHIVžÎ»ÀœÉ¿œ§Ñ

¿œÓ¶¸ÊÑʨ§Ñ¨ÀÊ¿ÑÁ¨ÔѠѵœÃҜ²¿¶Éœ¨ÀÊ¿ÑÁ¨ÔÑ´Ñ ª¨Éœ¿ÊœÒÓ¨µÑµÑԹѻÎÃξθœ¸¨ªÎÀξÑÿ¶²¨ ѶÊο¨À§Ñʿѵ¶ÃѵœÊѵɿޜÒÑÊÔ¿¸Î§Ñ¸¨5ÀԜ²Ñ #%ÒÑÀ¶É¿ÎÊÔ¨ÀλΧɿޜÒʶÒο§ÎʜÒÓ¨Ô Ò¨ª¨ª¨ÉÎʜÒÓ¨ÔÒ¨ª¾Î¸œÀÒ¨»Ñ½ÎÃÉεœÃ¨Ò¨ª¾Î ¸œÀÒ¨»ÑÓѾœ¸œÁœÒœÀ¶¨§¨»¿Îªœ§Ñʶ¿¨µÑ¨Àʜ¿¨¸ ÒÑɨµ¶¿¨µÑ#%£¸Ê¿ÑÓÔ¶´Ò¨§É¿œ²¸œÃΧµœ¶ÊÔ¿ ±œÒÎÃÑÀ¶¾¶¾¿œÓ¨ÎÔ¨ª¾Î¸œÀÒ¨»ÑÉÎÉ¿ÑÔ¨¸¶¶Ôœ¤Ñ Ò¨¨ª¨Éœ¿œªÎ²œÒ¨#%ƾ霠œ¾¶¾¿œ²ÑµœÒѵ´œ ¼¤œÖ¶¸§¨ÒÑÒÊÒβÊλѨÓÑÔ¿¼ÑÔÑÀœ¶¿œ§¨µÎ§ÉÎ À¸œÒœ»Î¸¨»ÎҜܹѨ¸¨Ê¿¨´œÊ¨¿¨§œÀœ®ÑÎõÑÔ¹Ñ  ÑɿԨªÀ¨§ÉÊΧÑ#%

šÑµ´œ¼¤ÑÉÑÊΧοÖθμ»ÑɿלÒѻεÑÀœÎɨÀ¶ µœ»ÎþθœÀÒ¨»ÑÀÑҜֿÎÉÑʨµÎ§¨ÓÑÓÔÑÒΧÀHIVje »Î¸ÑÉÀÒÑÖο§ÑÖλ¶ÀÒÎÀœ²§œÒÊҜ²¸Î§œ¿¶¸ÎÀ»¸œ ¿ÎӜ ij·³#%¦œ¿§¨Ò<»Î¸ÑÉÀÒÑ=ÎÓÒÑ´ÑÔѨӿÑÁœ Ò¶¿œÊ¿Ñ»®¨µ¶¨¸¨ÒѾ¨¿Ñ œ²¸Î§œ¿¶¸Î¾ÑÓѸҜ§œ§ ¾¿ÑҜ ·Í˼ÊΨ§ÑÓÑÉÎÀ¸œÃ¨®¶Î»¸¶Ó¨µ¶¸¶§œ ÒѲ¸Î§œ¿¶¸À»¨ª»Ñɨ¸Ñ¿Ñ»ÎµÑ§ÎÁœ¾¨Ê¨Àœ²§œÒÊ ÒѨ¸¨´œ¼¤œ²¸Î¾Ñ¸ÒÑ£ÓѪÔѤœÒ¨§Àœ²§œÒʨ§Ñ ɿѻʨ´ÒÎÀœÒœ§ÎÁœ¶Î´¨Ê¨§œÓÑÒ²¨µÀ»Ñɿθ¨Öœ ¿Ñ®¨µÑ»ÑÎÒ¨ª¨µÑ¸¨ÒÎÓÑ·ÎÊÎÔλÎÃÀÔ¨ª¾Î¸œÀÒ¨ »Ñ¶Î´ÑÔѵ¶Àœ¨Ó¿ÑÁœÒѪ¨Éœ¿Ê¿ÎÖ¨µÑ¨ª¨Éœ¿É¸ÑÓ¨ µÑÔ¨À®œ¿Ñ¸Ò¨ªœÉ¨Êœ¸Ò¨ª¤œ¸¨µÑ»Îµœ¨ÓÒÑûθÑÉ ÀÒΨӧœ œÒ¨ª¸Î¾¶¸¶ÀÑÔÑÀ»¶¸Ñ¿Òβ»¸¶¾œÊѲ¿Ñ Ü®œ¸¶¸Ñ¿ÒœÉθ¶§œÀœ´ÑÀʜÖο§Ñ®¨µœº¨À®œ¿Ñ¸Òœ œÉ¨Êœ¸Òœ¤œ¸¨µœ ÉÎÃή¨Ê¨À¶ÓÒÑÊÒΨӧœ œÒœ­¨ ªÎÔεœÃ¿Îµœ¶Ôœ¤ÑÒΨԜӨ»¶¸Ñ¿ÒÎѶ®¨ÊÎɸÑÓ§¨ ÀœÒѸÑӜ¾¿ÎµÒœÉ¿Îʜ¨ÒÀ»œ¿œÀοɮ¨ÎҜ»Ñɹ¨®œ »ÑΨԜ¤¨¾¿Îµ§¨ÊÎÓѝÀɨʨÔѠѶ»Îµ¨§ÑÀ¶»Î ¿¨¼¤œÒÑPCNA proliferation cell nuclear antigenÑÒʨ

tela pokazala su visok proliferacioni potencijal ÉÎÃή¨ÊÑ#%ŜʻÎÀœÒѲ¸Î§œ¿¶¸¨§Ñ§Î²¶¶ÊԿè ʨ¸œÓ¨µœ»ÎµœÀ¶Ê¨É¨´ÒœÓÑij·³»ÑμÊÎÀ¶ÉÎԜ ¤Ñ œ§œÓÑÒ²¨µÀ»Î²§ÑÊ¿¨»ÀÑèÀ»¿œÊÒ¨Àœ²§œÒÊÒ¨ ÎÁ¨¹®¨ª¨µÑ¸¨ÒÎÓѨ»ÑÉÀ¶¸ÒœÑêœÓ¨µœ

½ÎòÎÊÎÔÎÀÔ¨ª¾Î¸œÀÒ¨»ÑÀҜֿÎÉÑʨµÎ§¨ÓÑ zvanom sHIV¶Î´ÑÔÑÀœÒœÀ»¸Ñèӧœ±¶¾¸ÑÁ¨ªÉ¿Î

(2)

ƴƳƲƴƭƫƢƳƸƫƤƪƢƹƨƮƱƭƶƲưƱƮƨƭƢƳƴƵƤƱ

ʶ¾¶¸Î¨Òʜ¿Àʨ®¨µÀ»¨ªÉ¿Î§œÒѻεœÎ¾¶ªÔÑÊѵ¶Ãœ ²œÒœ¿Ñ®¨µ¶¨¿œ²œÒœ¿Ñ®¨µ¶œÉ¨Êœ¸Ñ»ÑÒѸ¨¤Ñʶ¾¶¸ À»¶ÑÊ¿ÎÖ¨µ¶œÃœ§¨Ö¨¾¿ÎÓ¶¨Òʜ¿Àʨ®¨µ¶§Ñ¶»Î µœ§Àœ´œÀÊÎÒѸÑӜԜΧѨӿÑÁœÒ¨ÓÑÉѹœ À»¨¨Ò Ö¨¸Ê¿ÑʨÓ¿ÑÁœÒÎÀÊʶ¾¶¸Î¨Òʜ¿Àʨ®¨µÀ»¨ªÉ¿Î §œÒѵœ§ÒβÎԜ¤Ñ»ÎþθœÀÒ¨»ÑÀÎÔ¨§Î¾Î¹œ œ§ Ҝ²Î»ÎþθœÀÒ¨»ÑÀÑij·³¶À»¸Îɶªœ¿Î¨ÒÀ»œÒœ Ö¿ÎÉÑʨµœ¨¸¨ÎÀξÑξθœ¸¨ªÎèèÎÉÑÊÀ»œÄ³·³ Òʜ¿Àʨ®¨µÀ»¨¨ÒÖ¨¸Ê¿ÑʨÀ¶ÀÑÀÊÑÔ¹œÒ¨É¿œÊœ

ÁÒÎÎø¨§Öή¨ÊѨÊÎÉ¿œÃΧ¨ÒÑÒÊÒÎCD8+T¤œ

¸¨µÑÉοœÃ»Îµ¨ªÀœÒѸÑÓ¨¨§Ñ ¨¾¿ÎµÉ¸Ñӧή¨ÊÑ monocita iB¸¨§Öή¨ÊѺœ¤µœÉלҶÊÎÃÑÀœ»ÎÃ

Ԝ¤¨Òœ¾Î¸œÀÒ¨»Ñ¶Î´ÑÔѵ¶Ãœ²œÒœ¿Ñ®¨µÑ¨ÑÊ¿ÎÖ¨µÑ œÉ¨Êœ¸Ñ»ÑÒѸ¨¤ÑÆÀ¨§ÊβѴœÀÊÎÀœ¶ÊÔ¿±¶µœ¨§¨ »¿Î®¨Àʨ´ÒÑè¸ÑÊÑ®¨µÑʶ¾¶¸Ñ¿Ò¨ª¸¶§œÒѶ»Îµ¨ §ÑÀœÒѸÑӜ¾œ¸ÑÒ´œÔ¨ÒÑÀʨ®¨¸¨Òÿ¨ÀÑÀÊÑÔ¹œÒ¨ ÎÃѸ¾¶§¨ÒѨ¨§¶Òβ¸Î¾¶¸¨ÒÑѸ¨Ò¨»ÑÃѨ¦Ñ§ ÂοÀÖѸÎÔβ TammHorsfallÉ¿Îʜ¨ÒÑ#%

U skorije vreme kodHIVÉÎӨʨÔÒ¨ªÎÀξÑÎɨ

ÀÑÒµœÒÑÀÊÑÒÑ»ÉÎÀœ¾ÒβʨÉÑÑ»¶ÊÒβ¨Òʜ¿Àʨ®¨µ skog nefritisa poznat kaoDILS diffuse infiltrative lymphocytosis syndromeDILS µœ À¨Àʜ§À»Ñ ¾Î¸œÀÊ

»ÎµÑÀœµÑԹѻÎçѸβ¾¿ÎµÑ¾Î¸œÀÒ¨»Ñ¨ÒÖ¨®¨¿Ñ nih sHIVÑÎø¨»¶µœÀœ¨Ó¿ÑÁœÒΧ¨ÒÖ¨¸Ê¿Ñ®¨µÎ§

É¿œÊœÁÒÎCD8 T¸¨§Öή¨Êѻε¨É¿ÎÁ¨§Ñµ¶¨Òʜ¿

Àʨ®¨µ¶§É¹¶ÔÑ´Ò¨ªÁ¸œÓÃÑɸ¶¤Ñ²ÑÀʿΨÒʜÀʨ ÒѸÒβʿѻÊѨ¾¶¾¿œ²Ñ#%½ÎÃÎÔ¨ª¾Î¸œÀÒ¨»Ñ »¸¨Ò¨´»¨ÀœÒѵ´œ¼¤œ¿ÑÓÔ¨µÑ¿œÒѸÒÑʶ¾¶¸À»ÑÑ®¨ doza tipIV·œÒœÊÀ»Ñ¨ÀɨʨÔѠѻεÑÀ¶Òœ»Î¸¨»Î

ÉÎÀ¸œÃ ¨ª²ÎèÒÑԜΧÑѻʶœ¸ÒÑÎÊ»¿¨¸ÑÀ¶²œÒœÊ sku predispoziciju za razvoj nefropatije izazvane

sHIV»ÎÃÎÀξÑÓÑ¿ÑÁœÒ¨ªÎÔ¨§Ô¨¿¶ÀΧ½ÎÃ

¾Î¸œÀÒ¨»ÑÀѾ¶¾¿œÁÒ¨§§ÑҨ֜ÀÊÑ®¨µÑ§ÑÎÊ»¿¨ ven jeHLADR5alelDRB1*1102iliHLADR6alel

DRB1*1301#%

§¶ÒÎÖ¸¶Î¿œÀ®œÒÊÒ¨ ÒѸÑÓ ÒÑ Ê»¨Ô¶ ¾¶¾¿œ²Ñ »ÎÃÎÀξÑξθœ¸¨ªÎÃÀ¨ÃœµœÒœÀɜ®¨Ö¨´ÑÒ¢œÀÊÎ Àœ¶ÒœÀ»¸œ¿Îʨ´Ò¨§²¸Î§œ¿¶¸¨§Ñ§Î²¶¶Î´¨Ê¨Ãœ pozitiIgM,C3ÑҜ¼ÊœC1£¨Òʜ¿É¿œÊÑ®¨µ¨

¨§¶ÒÎÖ¸¶Î¿œÀ®œÒÊÒ¨ªÒѸÑÓÑÊ¿œ¾Ñ¾¨Ê¨ÔœÎ§ÑÎ¾Ñ Ó¿¨ÔÃÑÀœ¿œÀοɮ¨ÎҜ»Ñɹ¨®œÉ¿Îʜ¨ÒѻεœÀœÉΠӨʨÔÒξεœÀÑÒʨʜ¸¨§ÑIgG,IgA¨Ñ¸¾¶§¨ÒÑÑ´œ

ÀÊÎÀœÒѸÑӜ¶®¨ÊÎɸÑÓ§¨Ô¨À®œ¿Ñ¸Ò¨ª¤œ¸¨µÑҜ É¿Îʶ§Ñ´œ»ÑΨ§¶ÒÀ»¨ÃœÉÎӨʨ¶²¸Î§œ¿¶¸¨§Ñ

›¸œ»Ê¿ÎÒÀ»Î§¨»¿ÎÀ»ÎÉÀ»Î§ÑÒѸ¨ÓΧʻ¨ÔѾ¶ ¾¿œ²Ñ»ÎÃÎÀξÑξθœ¸¨ªÎÃҜֿÎÉÑʨµœ¨ÓÑÓÔÑҜ sHIV¶Ôœ»Àœ¶Î´ÑÔѵ¶»Î¸ÑÉÀҜɿלҜÒѲ¸Î§œ¿¶

¸¨§Ñ»ÎµœÀœ¨ÀÉιÑÔѵ¶¶Ô¨Ã¶ÒѾ¨¿Ñ Ñ¨À»Ô¿´Ñ ÔÑ ÑÀœ²§œÒÑÊÑ·Í˝¶À»¸œ¿Îʨ´Ò¨§¨¶ÒœÀ»¸œ ¿Îʨ´Ò¨§Àœ²§œÒʨ§ÑµÑԹѵ¶Àœª¨Éœ¿Ê¿ÎÖ¨µÑ¨§¨ »¿ÎÔ¨¸¶ÀÒÑ Ê¿ÑÒÀÖο§Ñ®¨µÑ Ô¨À®œ¿Ñ¸Ò¨ª ¤œ¸¨µÑ »ÑÎ ¨ À¸œÉ¹œ œ  ¨ªÎÔ¨ª É¿ÀÊÑÀʨª É¿ÎöÁœÊÑ»Ñ ÅœÊ»ÎÀœ¶²¸Î§œ¿¶¸¨§Ñ§œÓÑÒ²¨µ¶§¶¨À¶¾œÒÃÎʜ¸ ÒÎÎÃÒÎÀÒÎɜ¿¨§œ§¾¿ÑÒÎÓÒÎöÁɜ¿¨Öœ¿Ò¨ª»Ñ ɨ¸Ñ¿Ò¨ªÉœÊ¹¨ÎɨÀ¶µ¶§Ñ¸¨²¶ÀʨÜÉÎӨʨ½Îà Ԩ¼œÎþ¨ÎÉÀ¨µÀ»¨ªÒѸÑÓѶ²¸Î§œ¿¶¸¨§Ñ¨œÒ ÃÎʜ¸¶»¿ÔÒ¨ªÀ¶ÃÎÔÑÀœ¶Î´ÑÔѵ¶¾¿ÎµÒœÊ¶¾¶¸Î¿œÊ¨ »¶¸Òœ¨Ò»¸¶Ó¨µœÆÒœÀœÀÑÀÊεœÎÃʶ¾¶¸Ñ¿Ò¨ªÀÊ¿¶»

ʶ¿ÑÉ¿œ´Ò¨»ÑÎÃnm»ÎµœÀœ§œ±¶ÀξÒÎÀÉѵѵ¶

ÑÀ§œ¼ÊœÒœÀ¶¶Ã¨¸Ñʨ¿ÑÒ¨§®¨Àʜ¿ÒѧќÒÃÎÉ¸Ñ Ó§ÑÊÀ»Î²¿œÊ¨»¶¸¶§Ñ³¸¨´Òœ¨Ò»¸¶Ó¨µœÀœ§Î²¶ÒÑ ¤¨¨¶®¨ÊÎɸÑÓ§¨¸¨§Öή¨Êѻε¨ÀœÒѸÑӜ¶¨Ò Ö¨¸Ê¿Ñʶ»ÑΨ¶®¨ÊÎɸÑÓ§¨ÉÎÃή¨ÊÑŜ±œÀœ§Î

²¶¶Î´¨Ê¨²¿ÑÒ¶¸¨¿ÑÒÑܲœÒœ¿Ñ®¨µÑª¿Î§ÑʨÒѶµœ ÿ¶¨Òʜ¿Àʨ®¨µÀ»¨ª¨Ê¶¾¶¸À»¨ª¤œ¸¨µÑ®¨Êל ²Ñ¸ÎÔ¨¿¶ÀҜ¨Ò»¸¶Ó¨µœ¨ÉÎԜ¤ÑÒ¾¿ÎµÒ¶»¸œ¶ÀÒ¨ª œ¸œ»Ê¿ÎÒÀ»¨²¶ÀʨªÊœ¸Ñ¼Ñ®Ñ#%

ËÒ⨨ÀÊ¿ÑÁ¨ÔÑ´¨À¶Éλ¶¼Ñ¸¨ÃÑξµÑÀҜ§œ ªÑÒ¨ÓѧÒÑÀÊÑÒ»ÑÎÃÒÎÀÒÎÉÑÊβœÒœÓ¶ÒœÖ¿ÎÉÑʨ je izazvane s HIVÇ¿œ§Ñ§¨¼¹œ ¶µœÃÒ¨ªÎÒѾ¨

§Î²¸Ñ ¾¨Ê¨ ÉÎÀ¸œÃ¨®Ñ 远»ÊÒβ μʜ¤œ Ñ ®¨ÊÎ ÉÑÊÀ»¨§ œÖœ»Ê¨§Ñ œÉ¨Êœ¸Ò¨ª Ô¨À®œ¿Ñ¸Ò¨ª ¨ ʶ ¾¶¸À»¨ª¤œ¸¨µÑ¶À»¸ÎɶԨ¿¶ÀҜ¨Ò֜»®¨µœÉÑ¿œÒ ª¨§Ñ¾¶¾¿œ²ÑÇ¿œ§Ñ§¨¼¹œ ¶Ã¿¶²¨ªÉ¿Î§œÒœÒÑ ÀÊѵ¶¨Ò远»ÊÒ¨§Î¼Êœ¤œ œ§¾¶¾¿œ²Ñ»ÎµœÒÑÀÊѵœ ÊѻμÊ検¸¨µœ¾¶¾¿œ²ÑÃÎÀɜÔѵ¶§Î¸œ»¶¸¨ÀÑÔ¨ ¿¶ÀÒ¨§Éѿʨ»¶¸Ñ§Ñ»Îµ¨ÀœÒѸÑӜ¶®¨¿»¶¸Ñ®¨µ¨ šÑ»¿Ñµ¶Òœ»¨¨ÀÊ¿ÑÁ¨ÔÑ´¨À§Ñʿѵ¶Ãѵœ§œªÑÒ¨ Óѧμʜ¤œ Ñ¾¶¾¿œ²Ñ¨Ò远»ÊÑÒ¨ÃѵœÉÎÀ¸œÃ¨ ®ÑÎÀ¸Î¾Ñ±Ñ Ñ®¨Êλ¨ÒÑÎÃÀÊ¿ÑҜÓÑ¿ÑÁœÒ¨ª¸¨§ focita ili monocita, kako u cirkulaciju, tako i u ÉÑ¿œÒª¨§¾¶¾¿œ²Ñ¶»Îµœ§ÀœÒѸÑӜ¶Ô¨Ã¶¨ÒÖ¨¸ Ê¿ÑÊѺ¿¸ÎԜ¿ÎÔÑÊÒΨӲ¸œÃÑʶ§Ñ´œ œÃѶ¿ÑÓÔε¶ nefropatije izazvane sHIVÔÑÁÒ¶¶¸Î²¶¨§Ñµ¶§œªÑ

Ò¨Ó§¨œ»ÀÉ¿œÀ¨µœ²œÒѸή¨¿ÑÒ¨ªÒѤœ¸¨µÑ§ÑÉÑ¿œÒ ª¨§Ñ¾¶¾¿œ²Ñ»Îµ¨À¶¨Ó§œ œÒ¨®¨Êλ¨Ò¨§Ñ¨ÖÑ»ÊÎ ¿¨§Ñ¿ÑÀÊÑÆÔ¨É¿Î®œÀ¨ÃÎÔÎÜÃΨÒʜ¿Àʨ®¨µÀ»œ Ö¨¾¿ÎӜ¨ÉεѴÑÒβÀÊÔѿѠѲ¸Î§œ¿¶¸À»Î²§ÑÊ¿¨» ÀѝӲ¸œÃÑÉ¿¨¿ÎÃÒÎÃÑ»¹¶´Ò¶¶¸Î²¶¶ÒÑÀÊÑÒ»¶Òœ fropatije uHIVinfekciji ima priroda odgovora ÃΧѤ¨ÒÑÒÑÔ¨¿¶ÀÒ¶¨Ò֜»®¨µ¶

šœ»¨ ¨ÀÊ¿ÑÁ¨ÔÑ´¨ ¨Àʨ´¶ §Î²¶¤ÒÎÀÊ Ã¨¿œ»ÊҜ

¨Ò֜»®¨µœ¤œ¸¨µÑ¾¶¾¿œ²ÑÀHIV½Ñή¨¹ÒלÀÊÎ

direktne virusne infekcije navodi se mezangijska ¤œ¸¨µÑ¶²¸Î§œ¿¶¸¶ËœÓÑÒ²¨µÀ»œ¤œ¸¨µœ¨§Ñµ¶§ÒβΠÀ¸¨´Ò¨ªÎÀξ¨ÒÑÀ§ÎÒή¨Ê¨§ÑžÎ»ÑÓÑÒεœÃÑÎҜ ÉÎÀœÃ¶µ¶§Î²¶¤œHIV§œ§¾¿ÑÒÀ»œ¿œ®œÉÊοœCD4ÑÒ

tigen iFcR#%›»Àɜ¿¨§œÒʨÒÑÁ¨ÔÎʨ Ñ§ÑÀ¶

pokazali daHIV§ÎÁœÃѨÒÖ¨®¨¿Ñ¨ÃÑÀœ¿œÉ¸¨®¨

ra u endotelnim, a u mawoj meri i u mezangijskim ¤œ¸¨µÑ§Ñ²¸Î§œ¿¶¸ÑѸ¨Òœ¨¶Ô¨À®œ¿Ñ¸Ò¨§œÉ¨Êœ¸ Ò¨§¤œ¸¨µÑ§ÑšÎ¨ÉοœÃÊβÑÎɼʜµœÉ¿¨ªÔѤœ ÒΧ¨¼¹œ œÃÑÀ¶¨§¶ÒΪ¨ÀÊڜ§¨µÀ»Ñ¾Îµœ Ñ¿Ñè dokazivawa virusnih proteinap24,p17,gp41igp120

¶Ê»¨Ô¶»ÎµœµœÖ¨»À¨¿ÑÒζÖο§Ñ¸¨Ò¶¨»Ñ¸¶É¹œÒÎ ¶ÉÑ¿ÑÖ¨Ò¶»¿Ñµ œÒœÉζÓÃÑÒўÑÒÑÀµœÒѵ¼¨¿œÉ¿¨ ªÔѤœÒΧ¨¼¹œ œÃѵœÃ¨¿œ»ÊÒѨÒ֜»®¨µÑ¾¶¾¿œ ga sHIV§œ±¶HIVÉÎӨʨÔÒ¨§¾Î¸œÀÒ¨®¨§Ñ´œÀÊÑ

Ѹ¨Ò¨µœÃÎÔιÒÑÓÑÒÑÀÊÑÒѻҜֿÎÉÑʨµœÓѻε¶À¶ ҜÎɪÎÃÒ¨¨Ã¿¶²¨É¿Ñʜ¤¨ÖÑ»Ê羽ÑÒÑÀÀœÓÒÑ da za razvoj nefropatije nije neophodno prisustvo Ô¨¿¶ÀѶʻ¨Ô¶¾¶¾¿œ²Ñ£Ò유œÔ¨¿¶ÀÒ¨ª²œÒÀ»¨ª É¿Îö»ÑÊѧÎÁœÊ¿ÑÒÀѻʨÔÑ®¨µÎ§²œÒÑÃΧѤ¨ÒÑ Ã¨¿œ»ÊÒΠ远»ÊÒ¨§ ܵÀÊÔΧ Ô¨¿¶ÀÒ¨ª ²œÒÀ»¨ª É¿Îö»ÑÊÑÒÑ®¨¹Òœ¤œ¸¨µœ¨¸¨¨Ò远»ÊÒÎ É¿œ»Î ÎÊɶ¼ÊœÒ¨ª®¨Êλ¨ÒÑÉλ¿œÒ¶Ê¨ÒÑÀÊÑÒѻҜֿΠÉÑʨµœ£Ãѹœ§À¸œÃ¶ÃβѱѵÑÃθÑÓ¨ÃÎѻʨԨ¿Ñ  Ñ¾ÑÓ¨´Òβ֨¾¿Î¾¸ÑÀÊÒβÖÑ»ÊοѿÑÀÊÑ bFGF) i

¾œÊÑÊ¿ÑÒÀÖ裡¼¶¤œ²ÖÑ»ÊοѿÑÀÊÑ TGFʊ°ÑÒ¨

§¹¨ÔεœÃѵμҨµœÉ¿œ®¨ÓÒÎÜ֨ҨÀÑÒѻʨÔÒ¨ ÜÎÔ¨¿¶ÀÒⲜÒÑÇ¿œÊÉÎÀÊÑÔ¹ÑÀœÃѶÊΧÀ§¨À¸¶ §œ±¶Ô¨¿¶ÀÒ¨§É¿Îʜ¨Ò¨§ÑÓÒѴѵҶ¶¸Î²¶¨§ÑÊÑÊ »Îµ¨§Î²¶ÎÀ¸Î¾Ñ±Ñʨ¤œ¸¨µœ¨ÒÖ¨®¨¿ÑҜԨ¿¶ÀΧ ¦ÑÊ ÉÎÃÀʨ´œ §Ñ»¿ÎÖѲœ »ÎÀÊҜ À¿Á¨ ÃÑ ÉÎÀɜ¼œ produkcijuTGFʊ»ÑΨ²¸¨µÑ¸Òœ¤œ¸¨µœÃÑÉÎԜ¤Ñ

(3)

ƴƳƲƴƭƫƢƳƸƫƤƪƢƹƨƮƱƭƶƲưƱƮƨƭƢƳƴƵƤƱ

֜»®¨µÑÊѻᜧÎÁœ¨ÓÑÓÔÑʨÉœ¤Ñµ¿œ²¶¸Ñ®¨ µœ¿ÑÓ¸¨´¨Ê¨ª®¨Êλ¨ÒÑÃΧѤ¨ÒѶ»¹¶´¶µ¶¤¨IL-1,

IL-6,TNF-α tumor necrosis factor alfa), kao i faktore »Îµ¨Àʨ§¶¸¨¼¶»Î¸ÎÒ¨µœ²¿ÑÒ¶¸Î®¨ÊѨ§Ñ»¿ÎÖÑ²Ñ Ëœ±¶Ê¨§ÎɼʜµœÉ¿¨ªÔѤœÒΧ¨¼¹œ œÃÑÉ¿Îö» tiHIVvirusnih genaper seÒ¨À¶ÃÎÔιҨÃÑÀÔ娧

ܵÀÊÔΧ¨ÓÑÓÎԶɿלҜ¶Î¾¸¨»¶ÒœÖ¿ÎÉÑʨµœžÑ ¸¨¤œÃÎÉεÑԜҜֿÎÉÑʨµœ¨ÓÑÓÔÑҜÀHIVÃΤ¨¨¸¨

ҜÓÑÔ¨À¨ÉοœÃÉלҶÊβܵÀÊÔÑÔ¨¿¶ÀѨÎÃÀÊÑ  ÑÎÃÒÎÀÒÎÎòÎÔοѨÒÖ¨®¨¿ÑÒβο²ÑÒ¨Ó§Ñ ÃÎ §Ñ¤¨ÒњÑÀªœ§¨É¿¨»ÑÓÑÒµœ§Î²¶¤¨ÒÑÀÊÑÒѻҜ fropatije u sklopuHIV¨Ò֜»®¨µœ

ьѳќъдгѳќ

½ÎþθœÀÒ¨»ÑÀÑHIV¨Ò֜»®¨µÎ§»¸¨Ò¨´»¨Àœ

§ÎÁœ¨ÀÉι¨Ê¨¼¨¿Î»Àɜ»ÊÑ¿À¨§ÉÊΧѻ娶»Ñ Ó¶µ¶ÒÑμʜ¤œ œ¾¶¾¿œ²ÑšÑµ´œ¼¤œÀœµÑÔ¹ÑÑ»¶ÊÒÑ ¨ÒÀ¶Ö¨®¨µœÒ®¨µÑ¿ÑÃѾ¶¾¿œ²Ñ ȝͻεѵœÎ¾¨´ÒÎ ÉÎÀ¸œÃ¨®ÑÀœÉÀœª¨ÉÎʜÒÓ¨µœ¨¸¨ÒœÖ¿ÎÊλÀ¨´Ò¨ª ѲœÒÀѽÎèÓԜÀÒβ¾¿ÎµÑ¾Î¸œÀÒ¨»Ñ§ÎÁœÒÑÀÊÑʨ nefropatija izazvana sHIV»ÎµÑµœÀ»¸œ¿ÎÓ¨¿Ñµ¶¤œ

É¿¨¿ÎÜ ¨ À§ÑÊ¿Ñ Àœ ξ¸¨»Î§ Öλ¶ÀÒÎÀœ²§œÒÊҜ ²¸Î§œ¿¶¸ÎÀ»¸œ¿ÎӜ»ÎµÑ¨§ÑÒѵɿβ¿œÀ¨ÔÒ¨µ¨Êλ U skorije vreme kodHIVÉÎӨʨÔÒ¨ªÎÀξÑÎɨÀÑÒ

µœÒÑÀÊÑÒÑ»ÉÎÀœ¾ÒβʨÉÑÑ»¶ÊÒβ¨Òʜ¿Àʨ®¨µÀ»Î² nefritisa poznat kaoDILS³¨§ÉÊΧ¨Î¼Êœ¤œ Ñ¾¶

¾¿œ²Ñ§Î²¶ÀœµÑԨʨ¶¾¨¸Î»ÎµÎµÖÑÓ¨HIV¨Ò֜»®¨

µœ³§Î¿Öθμ»Î²ÑÀɜ»Êѧœ±¶¿ÑÓÒÎÔ¿ÀÒ¨§ÀԜ ʸÎÀÒΧ¨»¿ÎÀ»ÎÉÀ»¨§É¿Î§œÒѧѵœÃ¨ÒÎÀ¶§¨»¿Î ®¨Àʨ´ÒÑè¸ÑÊÑ®¨µÑ»ÑÒѸ¨¤Ñ¾œ¸ÑÒ´œÔ¨ÒÑÀʨ§®¨ ¸¨Òÿ¨§Ñ ¨Òʜ¿Àʨ®¨µÀ»Ñ ¨ÒÖ¨¸Ê¿Ñ®¨µÑ ¨ Öλ¶ ÀÒÎÀœ²§œÒÊÒѲ¸Î§œ¿¶¸ÎÀ»¸œ¿ÎÓѶÊÔ¿±œÒ¨»ÎÃԜ ¤¨ÒœÎ¾Î¸œ¸¨ªÎÀξѝ§¶ÒÎÖ¸¶Î¿œÀ®œÒÊÒ¨ÒѸÑÓ µœÒœÀɜ®¨Ö¨´ÑÒÃ뵜ÒѸÑӜ¸œ»Ê¿ÎÒÀ»œ§¨»¿ÎÀ»Î ɨµœ¶Ôœ¸¨»Îµ§œ¿¨Àɜ®¨Ö¨´ÑҨɿœÃÀÊÑÔ¹ÑÉÎ¶Ó ÃÑÒèµÑ²ÒÎÀʨ´»¨§œÊÎÃ

LITERATURA

1. Gasrdenswartz MH, Lerner CW, Seligson GR, et al. Renal disease in patients with AIDS: A clinicopathologic study. Clin Nephrol 1984; 21:197-204.

2. Valeri A, Neusy AJ. Acute and chronic renal disease in hospitalized patients. Clinical Nephrol 1991; 35:110-8.

3. Rao TK, Freidman EA. Outcome of severe acute renal failure in patients with aquired immunodeficiency syndrome. Am J Kidney Dis 1995; 25:390-8.

4. D’Agati V, Suh JI, Carbone L, et al. The pathology of HIV nephrop-athy: A detailed morphologic and comparative study. Kidney Int 1989; 35:1358-70.

5. Pardo V, Bell M, Ortiz C, et al. The spectrum of glomerular lesions in patients with HIV infection [abstract]. Fed Proc 1989; 3:A1281. 6. Seney FD, Burns DK, Silva FG. Acquired immunodeficiency

syn-drome and the kidney. Am J Kidney Dis 1990; 16:1-13.

7. Mazbar SA, Schoenfeld PY, Humphreys MH. Renal involvement in patients infected with HIV: Experience at San Francisco General Hospital. Kidney Int 1990; 37:1325-30.

8. Bourgoignie JJ. Renal complications of human immunodeficiency virus type I. Kidney Int 1990; 37:1571-84.

9. Rao TK, Freidman EA, Nicastri AD. The types of renal disease in acquired immunodeficiency syndrome. N Engl J Med 1987; 316:1062-8.

10. Bourgoignie JJ, Meneses R, Ortiz C, et al. The clinical spectrum of renal disease associated with human immunodeficiency virus. Am J Kidney Dis 1988; 12:131-7.

11. Carbone L, D’Agati V, Cheng JT, Appel G. The course and progno-sis of human immunodeficiency syndrome. Am J Med 1989; 87:389-95.

12. Rao TK, Filippone EJ, Nicastri AD, et al. Associated focal and seg-mental glomerulosclerosis in the acquired immunodeficiency syn-drome. N Engl J Med 1984; 310:669-73.

13. Barisoni L, Szabolcs M, Ward L, D’Agati V. Visceral epithelial cell alterations in focal segmental glomerulosclerosis [abstract]. Mod Pathol 1994; 7:157A.

14. Cohen AH, Nast CC. HIV-associated nephropathy: A unique com-bined glomerular, tubular and interstitial lesion. Mod Pathol 1988; 1:87-97.

15. Itescu S, Brancato LJ, Buxbaum J, et al. A diffuse infiltrative CD8 lymphocytosissyndrome in human immunodeficiency virus (HIV) infection: A host immune response associated with HLA-DR 5. Ann Intern Med 1990; 112:3-10.

16. Itescu S, Brancato LJ, Winchester R. A sicca syndrome in HIV infection: Association with HLA-DR5 and CD8 lymphocytosis. Lancet 1989; ii:466-8.

17. Itescu S, Rose S, Dwyer E, Winchester R. Certain HLADR5 and -DR6 major histocompatibility complex class II alleles are associat-ed with a CD8 lymphocytic host response to human immunodefi-ciency verus type I characterized by low lymphocyte viral strain heterogeneity and slow disease progression. Proc Natl Acad Sci USA 1994; 91:11472-6.

18. Radojević S, Basta-Jovanović G, Oklobdžija M, Radotić-Smiljanić K, Đorđević LJ. Morphological changes in kidney of AIDS patients and their significance in diagnostics. Archive of Oncology 2001; 9(Suppl 1).

19. Karlsson-Parra A, Dimeney E, Fellstrom B, Klarkeskog L. HIV receptors (CD4 antigen) in normal human glomerular cells. N Engl J Med 1989; 320:741.

SHEMA 1.ƸǚǡǠǤǗǤǚǩǜǑǡǑǤǠǔǗǟǗǙǑǟǗǦǢǠǡǑǤǚǹǗǚǙǑǙǓǑǟǗǣHIV

SCHEME 1. Hypothetical pathogenesis of nephropathy caused by HIV.

VIRUSNA INFEKCIJA

ǍƨƮƫNJƨƲƢƳƨưƸƫƯƢƣƶƣƳƨƥƢ ƫưƵƳƢƳƨưƢƮưƫƮƫƯƷƱƹƫƵƫƫƯƱưƱƹƫƵƫ ƮƫƯƷƱƹƫƵƫƫƯƱưƱƹƫƵƫƶƹƫƳƭƶƮƢƹƫNJƫ

ƹƫƵƱƲƢƵƫƺưƫƨƷƨƭƵƫ ƱƣƳƢƧƢƲƳƱƧƶƭƢƵƢƤƫƳƶƴưƫƸƥƨưƢ ƫưƧƶƭƹƫNJƢƹƫƵƱƭƫưƢƧƱƯƢǍƫưƢ

(4)

ƴƳƲƴƭƫƢƳƸƫƤƪƢƹƨƮƱƭƶƲưƱƮƨƭƢƳƴƵƤƱ

ABSTRACT

HIV- (Human Immunodeficiency Virus) infected patients may be faced with a variety of renal problem patterns. Acute renal failure is common and most often the result of sepsis, hypertension, and toxic agents. Besides acute renal failure, HIV-associated nephropathy occurs in many HIV-positive patients, representing a unique pattern of sclerosing glomerulopathy. Many authors consider it to be the most rapidly progressive form of focal segmental sclerosis.

Key words: HIV; HIV-associated nephropathy; focal segmental glomerulosclerosis; acute renal failure

Gordana BASTA-JOVANOVIĆ Takovska 21, 11000 Beograd Tel: 011 769 027

HIV INFECTION AND THE KIDNEYS (PART I)

Gordana BASTA-JOVANOVIĆ

Institute of Pathology, School of Medicine, University of Belgrade, Belgrade

Referências

Documentos relacionados

as this study intends to insert Portugal into the circuit of the literature on academic tourism and this is a country that does not have the appeals of s’s offered by the leaders

Risk factors associated with sexual transmission of HIV-1 infection in healthy individuals, HIV-1 exposed but uninfected individuals, HIV-1-infected asymptomatic, and patients

dubliniensis in samples isolated from HIV-positive and HIV-negative patients with oral erythematous candidiasis, in the city of São Paulo, Brazil.. MATERIAL

6 Colour evolution of a PU MC PhPh suspension: (a) PU MC PhPh aqueous suspension, (b) after addition of one drop of sodium hydroxide solution (0.5 M), (c) after colour

HIV positive patients in Colombia. The objectives of this study were: i) to determine the frequency of serologic evidence of HBV and HCV infection in a group of HIV infected

The aim of the present study was to evaluate the frequency of KSHV infection in KS lesions from HIV-positive and HIV-negative patients in Brazil, as well as to review the

The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of

In order to review the effect of HIV infection in the development of vascular access-related infection on HIV- infected patients undergoing hemodialysis, we performed a