• Nenhum resultado encontrado

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.

N/A
N/A
Protected

Academic year: 2017

Share "Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K."

Copied!
11
0
0

Texto

Loading

Imagem

Fig 1. Mutant PI3K can lead to colon cancer development. Approximately 60% of Fc + Pik3ca H1047R mice develop tumors within the colon which can result in these mice becoming moribund
Fig 2. Fc + Pik3ca H1047R colon cancers are similar to those in Fc + Pik3ca p110 * mice
Fig 3. The PI3K pathway is activated in Apc Min/+ , Fc + Pik3ca p110 * , and Fc + Pik3ca H1047R mice.
Fig 5. Dual PI3K/mTOR inhibition induces treatment responses in Fc + Pik3ca H1047R colon cancers
+2

Referências

Documentos relacionados

A relação do poetaJosé Craveirinha com o futebol não será a mais simples de.. enunciar. Se ela ilustra a situação comum do escritor interessado por um

When EZH2 protein expression was significantly down-regulated by treatment with EZH2 siRNA the signal- ing proteins of the PI3K/Akt/mTOR pathway also showed a significant reduction

Constitutive activation of the PI3K/Akt pathway was demonstrated in T-ALL cell lines and our own data indicate that it is highly frequent in primary leukemia cells.. This

In the present study, we demonstrated that Que postconditioning attenuates myocardial I/R injury in rats via activating the PI3K/Akt pathway and modulating Bcl-2 and Bax

em que estiver e vir-se para Espanha ou para qualquer outra parte que o a-de poder fazer livremente e eu prometo e dou minha palavra de não lhe empe- dir a ditta viagem que

Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells.. Initiation of human

Hence, we have demonstrated the anti-cancer mechanism for MBT-induced cell cycle arrest and autophagy in HXO- RB44 cells to be through inhibition of PI3K/Akt signaling

embrionário (2) o centro do eixo embrionário (3) centro de um doscotilédones. B) Fluxo de oxigênio em locais diferentes de sementes de trigo (vermelho) com 91% e 0% de viabilidade,