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FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).

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Fig 1. C2C12 myoblasts overexpressing FRG1 exhibit a fusion defect. (A) Immunoblot analysis of FRG1 expression in C2C12 myoblasts expressing HA-vector or HA-FRG1
Fig 2. Generation of FRG1 and FRG1/FHL1 mice. (A) Immunoblot analysis of protein expression in the tibialis anterior, quadriceps, triceps and trapezius muscles from wild type, FRG1 and FRG1/FHL1 mice
Fig 3. FHL1 reduces muscle wasting in dystrophic FRG1 mice. (A) Representative X-ray images of the spine of mice from the indicated genotypes
Fig 4. FHL1 improves muscle pathology in dystrophic FRG1 mice. Representative images of transverse muscle sections from the triceps (A) or quadriceps (D) muscles of 6-week-old wild type, FRG1 and FRG1/FHL1 mice stained with H&E
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