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IMAGES IN NEUROLOGY

Transverse myelitis with Brown-Sèquard

syndrome after H1N1 immunization

Mielite transversa manifesta por síndrome de Brown-Sèquard após vacinação contra H1N1

Marcelo Adriano da Cunha e Silva Vieira

1

, Carlos Henrique N. Costa

2

, Chrystiany Plácido de B. Vieira

2

, Maria

do Amparo S. Cavalcanti

2

, Sebastião P. Ferreira-Filho

3

1Neurologist of Nathan Portella Tropical Diseases Institute, Federal University of Piauí, Teresina PI, Brazil; 2Nathan Portella Tropical Diseases Institute, Federal University of Piauí, Teresina PI, Brazil;

3Faculdade NOVAFAPI, Teresina PI, Brazil.

Correspondence: Marcelo Adriano da Cunha e Silva Vieira; Rua São Pedro 2.133; 64001-380 Teresina PI - Brasil; E-mail: macsvieira@superig.com.br Conflict of interest: There is no conflict of interest to declare.

Received 10 January 2012; Received in final form 09 March 2012; Accepted 16 March 2012. Durrant DH, True JM. Spinal cord syndromes and guide to neurological

1.

levels. In: Durrant DH, True JM (Eds). Myelopathy, radiculopathy and peripheral entrapment syndromes. Washington, DC: CRC Press, 2002:139-157.

Sheerin F, Collison K, Quaghebeur G. Magnetic resonance imaging of 2.

acute intramedullary myelopathy: radiological differential diagnosis for the on-call radiologist. Clin Radiol 2009;64:84-94.

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Agência 3.

Nacional de Vigilância Sanitária. Protocolo de vigilância epidemiológica de eventos Adversos pós-vacinação: estratégia de vacinação contra o vírus Influenza pandêmico (H1N1). Brasília: Ministério da Saúde, 2010.

References

Figure.

MRI image sagittal showing T2 hyperintese lesion on the dorsal aspect of the spinal cord at the level of the fourth thoracic

vertebra (A); axial MRI showing multiple tiny and T2 hyperintense lesions compromising the left lateral and dorsal aspect of the

spinal cord at same level (B and C).

A

B

C

A 52-year-old female had acute urinary hesitancy,

consti-pation, crural spastic asymmetric paraparesis and sensory

level at T6 (hypopalesthesia left and thermo-algesic

hypoes-thesia on the right mainly on sacral dermatomes) one week

after H1N1-trivalent immunization.

Magnetic resonance imaging showed thoracic

in-tramedullary lesion (Figure) and absence of brain indings.

Cerebrospinal luid was normal including electrophoresis,

viral polymerase chain reactions and cultures. HIV-serology,

VDRL, and anti-nuclear antibodies were nonreactive.

Brown-Sèquard syndrome commonly results from

trau-matic or tumor injury and is rarely found in other etiologies

1,2

.

Myelitis constitute possible adverse event temporally related

to immunization and his notiication contribute to

post-mar-keting studies on the safety of immunobiological extensively

Referências

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