β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites.

The cluster analysis based on sub-set B, which contained data for the non-covalent inhibitors (i.e. compounds that do not form a covalent bond to the catalytic serine residue) yielded

Figure 6. MS analysis identifies serine 61 as the principal phosphorylation site in Pdx1. To substantiate the NIA data we did mass spectometry to identify modified residues

In addition, the inhibitory effect of YC-1 on A b25–35 -induced m -calpain activation, p25 protein expression, and tau phosphorylation were significantly attenuated by pretreatment

The proinflammatory cytokines released by these cells bind to their receptor located in neurons and promote the activation of molecules such as JNK leading to serine phosphorylation

Mas se a comunidade de norte-americanos a residir em Portugal é residual, o mesmo já não acontece em relação ao turismo, o que não é de admirar, visto que os Estados Unidos são

Based on the idea that the addition of appropriate substituents at positions-1 and -3 might result in more potent compounds, we synthesized novel 1-substituted- phenyl- β

Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine

We demonstrated that the specific phosphorylation of this residue by the Hanks kinase YbdM stimulates phosphotransfer to DegU in vitro , and a phosphomimetic mutant of DegS leads to