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SHBG is an important factor in stemness induction of cells by DHT in vitro and associated with poor clinical features of prostate carcinomas.

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Academic year: 2017

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Figure 1. DHT induces cell growth and clonogenicity in prostate cancer cell lines. (A) Cell growth curves show statistically significant difference in LNCaP cells with/without DHT treatment, but not in PC-3 cells (* means P,0.05)
Figure 2. Stem-like phenotype analyses by flow cytometry. (A–C) CD44, CD24 and CD90 expressions were analyzed by flow cytometry in LNCaP and PC-3 cells cultivated with/without DHT in 10 nM for 48 hours
Figure 5. DHT upregulates the expression of stemess factors through SHBG. (A) Stronger immunocytochemical staining of SHBG is shown in LNCaP and PC-3 cells treated with DHT (left panel, bar scale: 50 mm)
Table 2. Comparison of clinical and pathologic characteristics by tumor SHBG intensity.

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