Estudos.

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Estudos

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BASE OPTIKEL

Gel para queloides e cicatrizes hipertróficas

DESCRIÇÃO

Base Optikel é uma combinação dos silicones que promovem a formação de um filme protetor com sensorial substantivo e altamente biocompatível.

BENEFÍCIOS

 Incorporação de ativos: atividade redutora de queloides e cicatrizes;

 Praticidade: fácil aplicação;

 Sensorial: agradável ocasionando maior adesão do produto (local seco) e do paciente;

 Segurança: não é absorvido a nível sistêmico;

 Ação: restrita ao local de aplicação, podendo ser reaplicado quando necessário.

INDICAÇÕES

 Queloides;

 Cicatrizes hipertróficas.

 Profilaxia em pós procedimento dermatológico específico;

 Pós roller e cirurgia.

MODO DE USO DA BASE OPTIKEL

1. Aplicar o Optikel sobre a área previamente seca e limpa, de modo a formar uma película fina e uniforme; 2. Reaplicar o produto quando a película começar a se desprender da pele.

Obs.: O produto só deve ser usado sobre tecido já inicialmentecicatrizado e sem indicação de uso de esparadrapo ou

outro tipo de correlato.

SUGESTÕES DE FÓRMULAS

PRINCIPAIS REFERÊNCIAS

BATISTUZZO, J. A O; ITAYA, M.; ETO, Y. Formulário Médico-Farmacêutico. 5 ed. São Paulo: Pharmabooks, 2015.

BLEASDALE, B. et al. The Use of Silicone Adhesives for Scar Reduction. Adv Wound Care (New Rochelle). v. 4, n. 7, p. 422-430. 2015.

Disponível em:<https://www.ncbi.nlm.nih.gov/pubmed/26155385>. Acesso em: 28/09/2016, às 15:21.

Tintura de Allium cepa... 10% Heparina... 5000 UI Alantoína... 1% Base Optikel qsp... 15g Modo de uso: aplicar gel sobre a área seca e limpa,

deixando uma película firme e uniforme. Reaplicar quando película começar a se desprender, 2 a 3 vezes

ao dia.

Indicação: queloide e cicatrizes hipertróficas. Tamoxifeno... 0,5%

Ácido lático ... 5% Betaglucan ... 2% Base Optikel qsp... 30g Modo de uso: aplicar gel sobre a área seca e limpa,

deixando uma película firme e uniforme. Reaplicar quando película começar a se desprender, 2 vezes ao

dia.

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OUTRAS SUGESTÕES DE FÓRMULAS

Vitamina D... 30.000 UI Vitamina E... 0,2% Vitamina A... 50.000 UI Base Optikel qsp... 50g Modo de uso: aplicar gel sobre a área seca e limpa,

deixando uma película firme e uniforme. Reaplicar quando película começar a se desprender. Indicação: queloide e cicatrizes hipertróficas. Heparina... 0,5% Vitamina D... 0,5% Vitamina E... 2% Vitamina A... 5.000 UI Alantoina... 0,5% Base Optikel qsp... 30g Modo de uso: aplicar gel sobre a área seca e limpa,

dia.

Indicação: estimular a regeneração tecidual.

Ácido hialurônico ... 5% Acetato de clobetasol ... 0,5% Hidroviton ... 2% Vegelip... 5% Base Optikel qsp... 15g Modo de uso: aplicar gel sobre a área seca e limpa,

dia.

Indicação: estimular a regeneração tecidual em procedimentos dermatológicos mais específicos.

Vitamina A... 50.000 UI Fator IGF... 2% Fator EGF... 2% Óleo de rosa mosqueta ... 5% Base Optikel qsp... 15g Modo de uso: aplicar gel sobre a área seca e limpa,

dia.

Indicação: estimular a regeneração tecidual.

Fator EGF ... 2% Fator TGF-β₃ ... 1% Óleo de rosa mosqueta ... 3% Base Optikel qsp... 15g Modo de uso: aplicar gel sobre a área seca e limpa,

dia.

Indicação: estimular a regeneração tecidual. Modukine... 1%

Betaglucan... 2% Fator TGF-β₃... 1% Base Optikel qsp... 30g Modo de uso: aplicar gel sobre a área seca e limpa,

dia.

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OPTIKEL

ESTUDOS

The use of silicone adhesives for scar reduction

Significance: This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Recent Advances: Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. Critical Issues: While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. Future Direction: The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring.

Efficacy and safety of an advanced formula silicone gel for prevention of post-operative scars

INTRODUCTION: Scar formation is a natural part of the healing process that occurs when the skin repairs wounds caused by burns, trauma, surgery or disease. The appearance of scars often leads to adverse psychological effects, loss of self-esteem and the associated stigmatism and diminished quality of life. Silicones are emerging as the standard treatment for prevention of a wide range of scars. The present study evaluated the safety and efficacy of an advanced formula topical silicone gel for prevention of post-operative hypertrophic and keloid scars. METHODS: An open-label prospective trial was conducted. Patients who had undergone prior surgery (10 days-3 weeks) and having recent post-surgical scars were enrolled. Patients were asked to apply the gel twice daily to the affected areas for 3 months. Pigmentation, vascularity, pliability, height of scar and pain and pruritus in the scar were assessed. Photographs of scars were taken before commencement of treatment and at follow-up visits. RESULTS: A total of 36 patients were enrolled. At baseline, height of the scar was 2-5 mm in 57.6 % (19/33) of the subjects which was reduced in subsequent visits (P < 0.05). Hyperpigmentation (score 3) was present in 91% (30/33) of patients at baseline and was reduced to normal (score 0) after 2 months of treatment in 40% (6/14) of patients (P = 0.0313). Vascularity (54.6%, 18/33) at baseline was also reduced over the 3 months period (P = 0.0313) A significant decrease (30%, 3/10) (P = 0.0313) in pliability was seen after 3 months of treatment from the baseline (57.6%, 19/33). Only two patients reported pruritus and pain at the baseline visit; one patient reported improvement after treatment. Itching was reported as an adverse drug reaction in two patients. CONCLUSION: These preliminary findings suggest that advanced formula silicone gel is safe and effective in the prevention of hypertrophic and keloid scars; however, larger, controlled studies are warranted.

Comparative effect of topical silicone gel and topical tretinoin cream for the prevention of hypertrophic scar and keloid formation and the improvement of scars

BACKGROUND: Numerous modalities have been used to treat keloids and hypertrophic scars; however, optimal treatment has not yet been established. Therefore, prevention is the mainstay. Recently, silicone gel and tretinoin cream have been shown to be useful for the prevention of hypertrophic scars and keloids. However, there has been no comparative study of the two topical agents thus far. OBJECTIVE: To determine and compare the effectiveness of silicone gel and tretinoin cream for the prevention of hypertrophic scars and keloids resulting from postoperative wounds and for scar improvement. METHOD: This study included 26 patients with 44 different wounds. The postoperative wounds were divided into two treatment groups and one control group. The patients in the first and second treatment group applied silicone gel and tretinoin cream, respectively, twice a day on their wounds after their stitches were removed. In contrast, the control group patients did not apply anything.

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We used the Modified Vancouver Scar Scale to quantitatively examine the effectiveness of silicone gel and tretinoin cream just after stitches removal, and at 4, 8, 12 and 24 weeks after removal of the stitches. RESULTS: The silicone gel and tretinoin cream effectively prevented hypertrophic scars and keloids and improved scar effects in the two treatment groups compared with those in the control group. However, no significant difference was noted between the two treatment groups. CONCLUSION: To prevent hypertrophic scars and keloids and improve scars after surgery, application of a silicone gel or a tretinoin cream to the wounds is needed.

REFERÊNCIAS

BATISTUZZO, J. A O; ITAYA, M.; ETO, Y. Formulário Médico-Farmacêutico. 5 ed. São Paulo: Pharmabooks, 2015.

BLEASDALE, B. et al. The Use of Silicone Adhesives for Scar Reduction. Adv Wound Care (New Rochelle). v. 4, n. 7, p. 422-430. 2015.

Disponível em:<https://www.ncbi.nlm.nih.gov/pubmed/26155385>. Acesso em: 28/09/2016, às 15:21.

MEDHI, B. et al. Efficacy and safety of an advanced formula silicone gel for prevention of post-operative scars. Dermatol Ther (Heidelb). v. 3, n. 2,

p. 157-167. 2013. Disponível em:<https://www.ncbi.nlm.nih.gov/pubmed/24254957>. Acesso em: 28/09/2016, às 15:29.

KWON, S. Y.; PARK, S. D.; PARK, K. Comparative effect of topical silicone gel and topical tretinoin cream for the prevention of hypertrophic scar and keloid formation and the improvement of scars. J Eur Acad Dermatol Venereol. v. 28, n. 8, p. 1025-1033. 2014. Disponível em:<