1118 Arq Neuropsiquiat r 2004;62(4)
ENTORHINAL CORTEX INVOLVEM ENT IN HUM AN M ESIAL TEM PORAL LOBE EPILEPSY (ABSTRACT)* .
DISSERTATION. M ARSEILLE, 2001.
DANIELA OLIVEIRA DE ANDRADE * *
* Ef eit o do t rat ament o in vit ro e in vivo do monot erpeno álcool perílico no cresciment o e cont role da expressão gênica no glioma de alt o grau (Resumo). Dissert ação de M est rado, Universidade Federal do Rio de Janeiro (Área: Neurologia). Orient adores: Abelardo de Queiroz-Campos Araújo; Thereza Quírico-Sant os
* * Address: Avenida Canal de M arapendi 1600 / 1303, 22631-050 Rio de Janeiro RJ, Brasil.
Introduction. Mesial temporal lobe epilepsy (MTLE)
is t he most f requent subt ype of t emporal epilepsy.
There is some evidence t hat mesial t emporal st
ruc-t ures oruc-t her ruc-t han ruc-t he hippocampus parruc-t iciparuc-t e in
seizure generat ion. In part icular, an increasing
num-ber of st udies demonst rat e t he involvement of t he
ent orhinal cort ex (EC) in t he TLE pat hogenesis.
Object ive. The role of t he EC in human M TLE
sei-zures genesis has rarely been directly studied. This study
aimed at det ermining t he respect ive role of t he EC
and ot her t emporal lobe st ruct ures in t he genesis of
M TLE seizures.
Method. Twenty seizures from 11 patients
present-ing w it h M TLE w ere analyzed. In addit ion t o visual
analysis of int racerebral recordings, a non-linear
measure of signal int erdependencies w as used t o
evaluat e t he f unct ional couplings occurring bet w een
t emporal lobe regions during seizures. Seizures w ere
classif ied according t o t w o f requent pat t erns of M TLE
seizure onset . The f irst pat t ern w as t he emergence
of a low -f requency, high-amplit ude rhyt hmic spiking
f ollow ed by a t onic discharge. The second pat t ern of
seizure onset w as t he emergence of a t onic discharge
in t he mesial st ruct ures.
Result s. The f irst pat t ern w as charact erized by an
init ial synchronizat ion bet w een mesial st ruct ures and
part icularly bet w een amygdala (A) and
hippocam-pus(H). Result s st rongly suggest ed t hat t he act ivit y of
t he EC w as secondarily t riggered by t he
hippocam-pus or in some cases t he amygdala. In pat t ern 2
seizures, t he t onic discharge af f ect ed simult
aneous-ly t he amygdala, t he hippocampus end t he ent
orhi-nal cort ex. These seizures appeared t o be init iat ed by
int eract ions bet w een t he EC and one of t he ot her
mesial st ruct ures (amygdala or hippocampus). The
ent orhinal cort ex w as f ound t o play a leader role
sug-gest ing t hat it is involved in t he init iat ion of t he ict al
discharge.
Conclusion. The ent orhinal cort ex is involved in
M TLE seizure generat ion in dif f erent w ays. It
appe-ars t o be a key st ruct ure in seizures t hat st art w it h
rapid discharges arising f rom mesial st ruct ures.
KEY WORDS: mesial t emporal lobe epilepsy,
ent orhinal cort ex, elect roencephalography.
and A172 cells. Furt hermore, previous in vit ro t reat
-ment of glioblast oma cells w it h 0.3% v/v and 0.03%
v/v POH show ed inhibit ion of cell migrat ion and ant
i-met ast at ic act ivit y in t he in vivo model of t he chick
embryo w it h C6 cell line.
Such result s indicat e t he chemot herapeut ic
ac-t ion of POH by promoac-t ing cyac-t oac-t oxiciac-t y and arresac-t ing
migrat ion of murine and human glioblast oma cell
lines.
KEY WORDS: glioblast oma chemot herapy, t
er-penes t herapeut ic use, gene expression, rat , in vit ro,
neovascularizat ion.
* Part icipação do córt ex ent orrinal na epilepsia do lobo t emporal mesial humana (Resumo). Dissert ação de M est rado, Universit é D`Aix-M arseille I, CHU Timone, INSERM EM I9926. Orient ador: Fabrice Bart olomei.
