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Dissertation to obtain the Master of Science Degree in Molecular Genetic and Biomedicine Supervisor: Professora Doutora Vanessa Alexandra Morais

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Academic year: 2019

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Figure  1.1  -  The  main  brain  regions  affected  in  Parkinson disease . Represented is a lateral brain’s  section,  with  the  anterior  to  the  left
Figure  1.2  -  Mitochondrial  Quality  Control.  Mitochondria have  different  pathways  to  promote  mitochondrial biogenesis  and  dynamics
Table 1.1  –  Most frequently genes implicated in monogenetic PD. Most frequently genes confirmed to be implicated in  autosomal dominant (AD) or autosomal recessive (AR) monogenetic PD
Figure 1.3 - PINK1 processing in healthy mitochondria; firstly PINK1 is imported into OMM through TOM, and then  IMM over TIM, where it is processed by MPP and PARL, exposing N-end rule substrate cytosolic and promoting PINK1
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