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Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) c Activators and Pan-PPAR Partial Agonists

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Figure 5. Rosiglitazone and MCFAs stabilize PPARc LBD in distinct ways. Variations in crystallographic B-factors represented as width of the backbone trace in PPARc-NA (left) and PPARc+rosi (right).
Figure 7. MD Simulations reveal a role for water in PPARc- PPARc-MCFA Interactions. (A) LBP showing superposed configurations of NA (white) observed in the simulations overlaid on native NA positions observed in the X-ray structure (red) and the correspond

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g Also at Department of Physics, California State University, Fresno CA, United States of America. h Also at Department of Physics, University of Fribourg,