• Nenhum resultado encontrado

Rev. Bras. . vol.72 número6 en a19v72n6

N/A
N/A
Protected

Academic year: 2018

Share "Rev. Bras. . vol.72 número6 en a19v72n6"

Copied!
1
0
0

Texto

(1)

849

BRAZILIAN JOURNALOF OTORHINOLARYNGOLOGY 72 (6) NOVEMBER/DECEMBER 2006 http://www.rborl.org.br / e-mail: revista@aborlccf.org.br

CASE REPORT

Cryptococcus Meningitis

and reversible hearing

loss

Janini Oliveira Matos 1, Andréia Migueres Arruda 2, Shiro

Tomita 3, Patricia de Pinho Marques Araujo 4, Felipe

Barbosa Madeira 5, Krishnamurti Matos de Araujo

Sarmento Junior 6

INTRODUCTION

Cryptococcosis is the most common fungal infection to strike the Central Nervous System. Its sub-acute manifestation includes fever, headache, nausea, and changes in behavior. Dysacousia takes place in up to 27% of patients, almost always bilaterally and suddenly1. Reversibility is rare and was described by Mayer et al. in 1990. In general terms, if no treatment is offered death is the ultimate consequence.

CASE STUDY

AJGG, female, 29 years of age, arrived in our center on December 25, 2003 with in-tense headache, discomfort, nausea, diplopia and reduced visual acuity; the symptoms had begun manifesting themselves two months before.

Her neck was stiff and the right ab-ducens paretic. CBC came back normal and the quick HIV test was negative. Latex test, nankin dye and LCR indicated Cryptococcosis. CT scan revealed cerebral edema.

The patient evolved to hypoacousia and then quickly to blindness and bilateral total hearing loss. The otolaryngological evaluation was normal, except for the paretic abducens.

The patient’s condition made it im-possible for audiometric tests to be conduc-ted. BERA had thresholds at 110 dBSPL to the

right and 100 dBSPL to the left, compatible with severe bilateral hearing loss for clicks. It was not possible to collect duplicated respon-ses at 130 dBNPL and thus waves I, III and V were not analyzed. Otoacoustic emissions were normal.

Treatment was initiated with intrave-nous Amphotericin B 50mg/day, getting to a dose of 1725 mg. The patient required a number of relief spinal taps and a ventriculo-peritoneal shunt.

After 100 days in the hospital the patient improved clinically and was dischar-ged without headache and neck stiffness, with partially recovered auditory acuity (picture) and multiple negative LCR cultures for fungi.

DISCUSSION

Cryptococcal meningitis may occur at any given age and is more prevalent in immunologically compromised patients 1.

Hypoacousia is described in as many as 27% of patients and may fluctuate1, with losses ranging from moderate unilateral to severe bilateral2. The mechanism leading to lesions in the auditory system has been stu-died. Igarashi et al.3 and Kwartler et al.4 have seen destruction of cochlear and vestibular structures, with the presence of microorga-nisms in the vestibulocochlear nerve, internal auditory meatus and cochlear structures.

Harada et al.5 have seen most of these alte-rations, however with normal Corti’s organ and preserved vestibular nerve in relation to the cochlear nerve. Therefore, despite the apparent disagreement as to the involvement of the cochlea, all authors concur that there is retrocochlear damage2. In this sense, normal otoacoustic emissions suggest preservation of the Corti’s organ.

Mayer et al. described Hypoacousia reversibility in 19908. The mechanism is ho-wever not fully comprehended.

Treatment of HIV-negative patients is done with amphotericin B and/or flucytosine for 6-10 weeks. This is a severe, potentially deadly disease.

CONCLUSIONS

Cryptococcal meningitis is a severe infection and its clinical signs are of diffi-cult diagnosis. Auditory involvement seems frequent, and its reversibility, rare. Early treatment is therefore of utmost importance, as is audiometric monitoring in the cases being followed.

REFERENCES

1. Hughes KV 3rd, Green JD Jr, Alvarez S, Reimer R. Vestibular dysfunction due to cryptococcal meningitis. Otolaryngol Head Neck Surg 1997;116(4):536-40.

2. Low WK. Cryptococcal meningitis: implications for the otologist. ORL J Otorhinolaryngol Relat Spec 2002;64(1):35-7.

3. Igarashi M, Weber SC, Alford BR, Coats AC, Jer-ger J. Temporal bone findings in cryptococcal meningitis. Arch Otolaryngol 1975;101(9):577-83.

4. Kwartler JA, Linthicum FH, Jahn AF, Hawke M. Sudden hearing loss due to AIDS-related cryp-tococcal meningitis--a temporal bone study. Otolaryngol Head Neck Surg 1991;104(2):265-9.

5. Harada T, Sando I, Myers EN. Temporal bone histopathology in deafness due to crypto-coccal meningitis. Ann Otol Rhinol Laryngol 1979;88(5 Pt 1):630-6.

6. Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, Sobel JD, Dis-mukes WE. Practice guidelines for the ma-nagement of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis 2000;30(4):710-8. Epub 2000 Apr 20. Keywords: cryptococcus meningitis, reversible hearing loss.

1 Second-year resident of otolaryngology.

2 Third-year resident of otolaryngology.

3 Full Professor of Otolaryngology, Head of the Otolaryngology Service. 4 Third-year resident of otolaryngology.

5 Otolaryngologist.

6 Otolaryngologist. Per-oral Endoscopist.

Otorhinolaryngology Department - Clementino Fraga Filho University Hospital – Federal University of Rio de Janeiro. E-mail: janini_matos@ig.com.br

Paper submitted to the ABORL-CCF SGP (Management Publications System) on March 8th, 2005 and accepted for publication on June 14th, 2006. cod. 22. Rev Bras Otorrinolaringol

Referências

Documentos relacionados

Despercebido: não visto, não notado, não observado, ignorado.. Não me passou despercebido

Para tanto, suponhamos a existˆ encia de um mapa pentacrom´ atico m´ınimo, normal ou n˜ ao, contendo um pa´ıs que possui quatro vizinhos.. Em seguida, retiraremos tal pa´ıs e,

As doenças mais frequentes com localização na cabeça dos coelhos são a doença dentária adquirida, os abcessos dentários mandibulares ou maxilares, a otite interna e o empiema da

Neste trabalho o objetivo central foi a ampliação e adequação do procedimento e programa computacional baseado no programa comercial MSC.PATRAN, para a geração automática de modelos

Peça de mão de alta rotação pneumática com sistema Push Button (botão para remoção de broca), podendo apresentar passagem dupla de ar e acoplamento para engate rápido

Estes dados sugerem uma exigência maior do mercado de trabalho atual deixando os egressos que foram formados mais recentemente inseguros ao sair da faculdade, vale salientar que

Assim o conhecimento se constitui num processo de homem com o mundo, como um conjunto de sistematizações no qual o homem produz para além de se comunicar, sobreviver e

Para determinar o teor em água, a fonte emite neutrões, quer a partir da superfície do terreno (“transmissão indireta”), quer a partir do interior do mesmo