Association studies
Blocking approach for identification of rare variants in family-based association studies.
... variant association analysis is increasingly being conducted to identify genetic variants associated with complex ...variant association tests to rare variants association ...
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Epigenome-wide Association Studies and the Interpretation of Disease -Omics.
... Epigenome-wide association studies represent one means of applying genome-wide assays to identify molecular events that could be associated with human ...epigenomic studies represent a broader ...
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Utilizing twins as controls for non-twin case-materials in genome wide association studies.
... and association analysis ...disease-specific studies from the same background ...genetic association studies using twins as controls is that the genetic architecture of twins and non-twins is ...
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Statistical power of model selection strategies for genome-wide association studies.
... genome-wide association studies (GWAS), hundreds of thousands of markers are genotyped to identify genetic variations associated with complex phenotypes of ...
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Exploiting SNP correlations within random forest for genome-wide association studies.
... The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however, ...
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Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies
... in association studies conducted on this population, the clustering of “worse” variants was more prominent in the black than in both the Caucasian and the mulatto ...an association between these ...
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Correction of population stratification in large multi-ethnic association studies.
... most association studies include several hundred cases and controls from one single population, but the sample sizes are out of necessity increasing as a result of the expected relatively modest associa- ...
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Gene networks from genome wide association studies for pigs reproductive traits
... SNP association studies that consider continuous phenotypes under Gaussian assumptions, this trait is characterized as discrete variable, which could potentially follow other distributions, such as the ...
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A network-based approach to prioritize results from genome-wide association studies.
... Genome-wide association studies (GWAS) are a valuable approach to understanding the genetic basis of complex ...genetic association results into biological hypotheses suitable for further ...
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Properties of local interactions and their potential value in complementing genome-wide association studies.
... Local interactions between neighbouring SNPs are hypothesized to be able to capture variants missing from genome-wide association studies (GWAS) via haplotype effects but have not been thoroughly explored. ...
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Reporting of systematic reviews: the challenge of genetic association studies.
... the association between genetic variation and human diseases ...genetic association studies [5] and in the reporting of SRs of such associations ...
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Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.
... Genome-wide association studies (GWAS) have revealed many single nucleotide polymorphisms (SNPs) associated with complex ...these studies frequently fail to identify statistically significant ...
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Genome wide association studies for milk production traits in Chinese Holstein population.
... Genome-wide association studies (GWAS) based on high throughput SNP genotyping technologies open a broad avenue for exploring genes associated with milk production traits in dairy ...design. ...
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The search for circadian clock components in humans: new perspectives for association studies
... Designing association studies based on the HapMap drastically increases the chances of “tag- ging” the causal variant with an LD-based strategy, thus, preventing inconsistencies that may result in single ...
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On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
... family-based association test for genome-wide association studies that combines all sources of information about association, the between and the within-family information, into one single ...
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Use of genome-wide association studies for cancer research and drug repositioning.
... Since the advent of high-density single nucleotide polymorphism (SNP) genotyping arrays, re- searchers have used genome-wide association studies (GWAS) to identify innumerable loci as- sociated with a ...
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Quantifying the underestimation of relative risks from genome-wide association studies.
... Genome-wide association studies (GWAS) have identified hundreds of associated loci across many common diseases. Most risk variants identified by GWAS will merely be tags for as-yet-unknown causal variants. ...
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Prediction of disease and phenotype associations from genome-wide association studies.
... Genome-wide association studies (GWAS) have become a popular method for surveying genetic variations, such as single nucleotide polymorphisms (SNPs) and classifying heritable risk factors associated with a ...
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Informed conditioning on clinical covariates increases power in case-control association studies.
... case-control association studies often include data on clinical covariates, such as body mass index (BMI), smoking status, or age, that may modify the underlying genetic risk of case or control ...
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Detecting rare variants in case-parents association studies.
... genome-wide association studies (GWASs) in detecting common variants (minor allele frequency ...group-wise association between multiple rare (and common) variants in a gene region and a ...simulation ...
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