ATP-binding cassette
The hypocholesterolemic activity of açaí ( Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat
... Previous studies have demonstrated that the ingestion of açaí pulp can improve serum lipid profile in various animal models; therefore, we hypothesized that açaí pulp (Euterpe oleracea Mart.) may modulate the expression ...
9
Prognostic significance and molecular mechanism of ATP-binding cassette subfamily C member 4 in resistance to neoadjuvant radiotherapy of locally advanced rectal carcinoma.
... active ATP-dependent export pump belonging to the ATP-binding cassette transporter super- family for exporting cyclic nucleotides and organic anions across extra- and intra-cellular membranes ...
10
Up-regulation of ATP-binding cassette transporters in the THP-1 human macrophage cell line by the antichagasic benznidazole
... Treatment of intracellular infections requires the use of chemotherapeutic agents capable of penetrating eukaryotic cells and reaching an optimal concentration to eliminate the causal agent (Tulkens 1990). The intra- ...
5
Whole-genome survey of the putative ATP-binding cassette transporter family genes in Vitis vinifera.
... The ATP-binding cassette (ABC) protein superfamily constitutes one of the largest protein families known in plants. In this report, we performed a complete inventory of ABC protein genes in Vitis ...
15
Association of three common single nucleotide polymorphisms of ATP binding cassette G8 gene with gallstone disease: a meta-analysis.
... The aims of our study are: 1) to evaluate the association between polymorphisms at D19H, T400K and Y54C and gallstone disease using meta-analysis; 2) to compare the hepatic ABCG5/G8 mRNA[r] ...
11
Arabidopsis thaliana AUCSIA-1 regulates auxin biology and physically interacts with a kinesin-related protein.
... Aucsia is a green plant gene family encoding 44–54 amino acids long miniproteins. The sequenced genomes of most land plants contain two Aucsia genes. RNA interference of both tomato (Solanum lycopersicum) Aucsia genes ...
17
Optimizing expression and purification of an ATP-binding gene gsiA from Escherichia coli k-12 by using GFP fusion
... of ATP binding cassette transporters can provide the necessary energy by binding and hydrolyzing ...an ATP binding transporter from ...cleotide binding domains of the ...
8
Application of selection mapping to identify genomic regions associated with dairy production in sheep.
... – CCR3 (OAR6:30.367–41.863 Mb). The three analysis methods identified this region of positive selection in the first half of OAR6, which includes the ABCG2 (ATP-binding cassette, sub-family G ...
13
The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells.
... Markers of metabolism: ATP-binding cassette transporter protein 1 ( Abca1 ), fatty-acid binding protein 3 ( Fabp3 ) and sterol regulatory element binding protein 1c ( Srebp-1c ), respect[r] ...
15
Paraoxonase-1 is not a major determinant of stent thrombosis in a Taiwanese population.
... Dual antiplatelet therapy with aspirin and clopidogrel, an adenosine diphosphate (ADP)-P2Y12 receptor antagonist, has become the standard treatment for patients with coronary artery disease (CAD) who undergo percutaneous ...
6
Rev. bras. farmacogn. vol.21 número5
... Abstract: Multidrug resistance of cancer cells and pathogenic microorganisms leading to the treatment failure of some forms of cancer or life-threatening bacterial or fungal infections is often caused by the ...
7
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
... of ATP-dependent fli- pase aminophospholipid translocases, which nor- mally brings PS back to the inner membrane (Fadok et ...(ATP)- binding cassette protein 1 (ABC A1) on the engulf- ment of ...
23
Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors.
... MM CSCs have been proposed to be responsible for drug resistance and a relapse although they are not properly defined yet [5]. SP cells are identified as a drug resistant fraction by their ability to efflux a Hoechst ...
9
c-Src binds to the cancer drug Ruxolitinib with an active conformation.
... Ruxolitinib binding to the ATP-binding pocket of c-Src To see how cancer drug Ruxolitinib interacts with a kinase, we determined the X-ray structure of c-Src in complex with Ruxolitinib to a ...
8
ATP as a presynaptic modulator
... store ATP together with acetylcholine [4,101] and that ATP is released with acetylcholine at neuromuscular synapses [23,102,103] make ATP a likely transmitter or modulator in these cholinergic ...
19
Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
... The ATP binding pocket is between the NTD and CTD, and it is surrounded by the hinge region, glycine-rich loop (G-loop, residues 46–54), and activation loop (A-loop, residues 191–202) [5] ...the ATP ...
7
Introdução à biocristalografia com o estudo estrutural da quinase dependente de ciclina...
... fosforilado para que a CDK2 se tome ativa, se reorienta completamente na estrutura do complexo temario e (5) 0 motivo "PSTAIRE" da CDK2, tambem chamado de helice de liga9ao de ciclina, muda sua localiza9ao e ...
182
Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model.
... poly(A) cassette insertion activates expression of Ube3a from the paternal chromosome, and ameliorates many disease-related symptoms in the AS mouse model, including motor coordination defects, cognitive deficit, ...
13
Fosforribosilpirofosfato sintase de Mycobacterium tuberculosis tipo selvagem : uma PRS classe II bacteriana?
... nucleotide binding pocket is located in a wide cleft, and the secondary structure elements might undergo conformational rearrangements upon ligand binding to accommodate both purine and pyrimidine bases, as ...
91
The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.
... Figure 7. The structure of Japanese luciferase in the vicinity of the main photolabeled residues. The structure is shown as a cross section through the luciferin pocket with DSLA bound in the luciferin and ATP ...
14