Cancer progression
Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis.
... breast cancer into potentially clinically relevant ...breast cancer cohort ...breast cancer subtype classification, which in turn could enable clinicians to tailor treatment to individual ...
16
Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression.
... systemic progression in prostate cancer patients, and higher levels of TOP2A were found in hormone-resistant ...tumor progression we gener- ated TOP2A overexpressing prostate cancer cell ...
17
Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression.
... in cancer progression has been established in colorectal cancer (CRC) where lamin A expression predicts poor outcome when compared to lamin A negative cancers ...PCa progression (Fig ...
16
Modeling cancer progression via pathway dependencies.
... tumor progression rather than single ...tumor progression has studied single genes that can be used as markers of certain stages ...during progression has been missing. Recent research in prostate ...
13
Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression
... Hyper O-GlcNAcylation is known to upregulate key oncogenes and play an important role in cancer metabolism and tumorigenesis. However, the precise mechanism of oncogenic activation by O-GlcNAcylation resulting in ...
32
Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.
... of cancer, including lung ...examining cancer incidence in diabetic patients using TZDs demonstrated a 33% reduction in lung cancer risk [9], with an even more dramatic reduction in African-American ...
11
Cancer progression mediated by horizontal gene transfer in an in vivo model.
... that cancer progresses by vertical gene transfer, but this paradigm ignores that DNA circulates in higher organisms and that it is biologically active upon its uptake by recipient ...colon cancer patients ...
12
Network analysis of breast cancer progression and reversal using a tree-evolving network algorithm.
... The HMT3522 isogenic human breast cancer progression series has been used to study the effect of various drugs on the reversion of the breast cancer cells. Despite significant efforts to delineate ...
18
Elevated microRNA-31 expression regulates colorectal cancer progression by repressing its target gene SATB2.
... Over the last decade, it has become evident that miRNAs are involved in the pathogenesis of several human diseases, including cancer. An increasing number of in vitro studies have demonstrated an important role of ...
14
Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.
... breast cancer cases ...breast cancer specific survival [28]. Recently two further small breast cancer studies have confirmed the association of reduced Microcephalin expression with tumour ...
14
Identification of novel glycosylation patterns in cancer and their role in cancer progression and metastasis
... in cancer, such as the epithelial-mesenchymal ...cycle progression, tumour growth, angiogenesis and invasion, as well as proinflammatory cytokines, including IL-1β and IL-6, whose expression was assessed by ...
50
MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha.
... breast cancer [29], colorectal cancer [30], gastric cancer [31], and pancreatic cancer ...and progression of ...lung cancer cell, indicating its important biological role in ...
9
Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
... According to the Lauren's classification two main types of gastric carcinomas, well differentiated (intestinal type) and diffuse types, has been defined. In the diffuse variant, single cells or poorly cohesive clusters ...
12
Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression.
... lung cancer patients, possibly due to epigenetic silencing ...breast cancer suggested that SATB1 expression did not promote breast cancer progression and was not associated with disease ...
11
Mecanismos moleculares da progressão do cancro da bexiga e modulação metabólica induzida pelo extrato de chá branco
... other cancer types, the Warburg Effect has also been verified in urinary bladder tumors, reflected in altered levels of glycolysis intervenients, such as pyruvate, enzymes and GLUTs (Langbein, et ...bladder ...
95
Is there a role for voltage-gated Na
... during cancer progression must be considered and further ...tumor progression because of their role in increasing extracel- lular matrix degradation, cathepsins are also involved in apoptosis ...
10
ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer.
... Most bladder cancers express elevated levels of the epidermal growth factor receptor (EGFR) [5,6,7]. EGFR modulates cell growth and proliferation as well as regulating gene expression, angiogenesis, motility and ...
18
Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells.
... prostate cancer aggressiveness, as indicated by Gleason score, with highest expression in metastasis samples (Figure ...prostate cancer tissue microarrays, which consist of 14 castration resistant (CRPC) ...
14
Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer.
... significant overexpression of both HFE [21], and TFR1 [21–23] in HNSCC patient samples, demonstrating that this is indeed a commonly dysregulated pathway in this disease. Moreover, HFE was also overexpressed in other ...
14
Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells.
... Akt is a serine/threonine protein kinase regulating inhibition of apoptosis and stimulation of cell proliferation. Up-regulation of PI3K/Akt activity is associated with poor clinical outcome of prostate cancer ...
12