Cannabinoid Receptor
Activation of Type 1 Cannabinoid Receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures
... 1 cannabinoid receptor (CB1R) activation on self-renewal, proliferation and neuronal differentiation in mouse neonatal subventricular zone (SVZ) stem/progenitor cell ...
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Genetic variations in the human cannabinoid receptor gene are associated with happiness.
... human cannabinoid receptor 1 gene is associated with sensitivity to positive emotional ...human cannabinoid receptor 1 genotypes, are closely related to the two aspects of ...human ...
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The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.
... of Cannabinoid Receptor type 2 (CB2) expression levels in human Mesenchymal Stromal Cells from passage 3, ...(B) Cannabinoid Receptor type 1 (CB1) expression levels showed a significant ...
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Loss of cannabinoid receptor CB1 induces preterm birth.
... Background: Preterm birth accounting approximate 10% of pregnancies in women is a tremendous social, clinical and economic burden. However, its underlying causes remain largely unknown. Emerging evidence suggests that ...
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Characterization of the affective behavioral effects of chronic adolescent exposure to the cannabinoid receptor agonist HU-210 in female rats
... of cannabinoid receptor agonists, one may be at risk of ignoring the totality of the possible effects of ECS modulation and of forming possibly erroneous conclusions, extrapolated from data obtained with ...
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A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain.
... We have previously shown that genetic variability in CNR1 is associated with low HDL dyslipidemia in a multigenerational obesity study cohort of Northern European descent (209 families, [r] ...
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Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells.
... hippocampal neurons is the mTOR/p70S6K pathway, which mediates the modulatory effects of eCBs on long-term memory [17]. Thus, we investigated the phosphorylation levels of ERK1/2 and of the ribosomal protein S6 (rpS6), ...
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Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice.
... Imbalance in the ratio of the T cell subgroups and inflammatory monocytes as well as in their effector cytokines can modulate atherogenesis and plaque composition in mice [36,37]. Several studies have shown that THC ...
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Modulation of pilocarpine-induced seizures by cannabinoid receptor 1.
... Induction of SE causes many changes in the brain, including increased neurogenesis, gliosis, mossy fiber sprouting, and cell death [10,11]. We confirmed that pilocarpine-induced SE caused the expected increases in cell ...
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Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.
... the cannabinoid receptor 1 antagonist rimonabant (SR1, 3 mg/kg) and the peroxisome proliferator-activated receptor alpha antagonist GW6471 (4 ...the cannabinoid receptor 2 antagonist ...
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Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.
... The cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2) are members of the G-protein coupled receptor (GPCR) family, that are activated by endogenous ligands, the ...
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Identification and pharmacological evaluation of surrogate ligands of cannabinoid receptors
... a cannabinoid receptor is also supported by studies that found that the phytocannabinoid Δ 9 -THC and the synthetic cannabinoids abn-CBD and O-1602 act ...
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CB2 cannabinoid receptors contribute to bacterial invasion and mortality in polymicrobial sepsis.
... One view holds that immune dysfunction during sepsis is a result of autocrine/paracrine immunoregulatory mediators that are produced primarily at the site of infection/injury (including the bloodstream) and suppress ...
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Expressão gênica de adipocinas em ovelhas alimentadas com resíduos da indústria do biodiesel da mamona.
... Bonnet et al. (2009) verificaram que a substituição parcial do concentrado comercial por alimentos alternativos à base de óleo de girassol oleico e/ou óleo de linhaça, durante 21 dias, não alterou os níveis de RNAm para ...
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Braz. oral res. vol.23 número4
... 10. Fan CY, Melhem MF, Hosal AS, Grandis JR, Barnes EL. Expression of androgen receptor, epidermal growth fac- tor receptor, and transforming growth factor alpha in sali- vary duct carcinoma. Arch ...
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Fatores hormonais e genéticos na próstata normal e neoplásica.
... Entre esses mecanismos, estão os sinais desencadeados pelos fatores de crescimento e pelo receptor de andrógenos, as alterações que aumen- tam ou tornam a atividade desse receptor indepe[r] ...
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Pereira, Carlos Victor Montefusco
... With the occurrence of synthetic cannabinoids in commercial herbal blends from 2008, various research cores have use liquid or gas chromatography with mass spectrometry (LCMS; GC-MS) in order to point out its presence on ...
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Colaboração entre quimiocinas e peptídeos mitocondriais no recrutamento e ativação de neutrófilos durante a lesão hepática estéril
... alvos para uma terapêutica alternativa e mais eficaz. Assim, decidimos quantificar alguns mediadores inflamatórios estabelecidos, como as citocinas IL- 1β, IL-6, TNFα e as quimiocinas CXCL1 e CXCL2, cujo papel no ...
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Rev. Bras. Psiquiatr. vol.39 número2
... consider the effects of exogenous and endogenous canna- binoid compounds alike on the brain. It is well established that the psychogenic properties of cannabis are mainly mediated by delta-9-tetrahydrocannabinol (THC) ...
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Estudo comparativo morfológico e imunoistoquímico entre citoinclusão e espécime cirúrgico de carcinoma primário da mama
... Com o advento da ultrassonografia, a realização do diagnóstico mais precoce do câncer de mama tornou-se viável, possibilitando a identificação de lesões muito menores. Isso impossibilitou, em muitos casos, a obtenção de ...
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