CD8(+) T cells
Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function.
... specific CD8+ T cells may harbor a regulatory population that may be absent in the CD8+ T cells generated against foreign antigens like ...avidity CD8+ regulatory T ...
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Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes
... studies, CD8+ T cells were retrieved and characterized using different methodological approaches in terms of patient groups or murine models, biological samples, and study ...antigen-producing ...
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miRNA profiling of naive, effector and memory CD8 T cells.
... antigen-induced T cell differentiation, the role of miRNAs in the process is not ...memory CD8+ T cells using 3 different methods-small RNA cloning, miRNA microarray analysis and real-time ...
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Phenotypic changes induced by IL-15 in human CD8+ T cells in vitro
... Blood samples (i.e., phlebotomies) from hereditary hemochromatosis (HH) patients (n=7; all males; mean age 48 years; range 31-57), secondary hemochromatosis (SH) patients (n=2; mean age 67 years; both man and same age) ...
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The role of CD8+ T cells during allograft rejection
... In a model of aorta transplant in mice (36) it was shown that anti-CD40L and anti- CD4 therapy could delay but not prevent the graft from developing transplant arterioscle- rosis. Anti-CD8 antibody caused a ...
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Local induction of immunosuppressive CD8+ T cells in the gut-associated lymphoid tissues.
... 27. von BH (2007) Oral tolerance: is it all retinoic acid? J Exp Med 204: 1737–1739. 28. Endharti AT, Rifa’I M, Shi Z, Fukuoka Y, Nakahara Y, et al. (2005) Cutting edge: CD8+CD122+ regulatory T cells ...
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Modulation of CD4(+) T Cell-Dependent Specific Cytotoxic CD8(+) T Cells Differentiation and Proliferation by the Timing of Increase in the Pathogen Load
... In initial studies we investigated the development of T. cruzi parasitemia in wild type C57BL/6 mice challenged i.p. with different doses of trypomastigotes (10 2 , 10 3 , 10 4 or 10 5 parasites per mouse). As ...
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Phenotypic and functional aspects of CD8 + T cells in atopy: from populations to cells
... Both CD8+ T cell subpopulations showed similar proliferation capacity in atopic and non-atopic individuals, and did not show suppressor ...blood T cells do not share the same cellular ...
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Viral sequestration of antigen subverts cross presentation to CD8(+) T cells.
... assays, cells were incubated on ice with Fc block containing 20% normal mouse serum (Sigma) for 20 min prior to ...noted. Cells were stained with anti-CD8 PE-Cy5 (Clone ...Fixed cells were ...
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Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites
... Recently, it has been determined that, in fact, there is a shift in the sporozoite forms from the arthropod vector to the mam- malian host that is responsible for the activation of the steady- state form of the parasite ...
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Characterization of a novel single-chain bispecific antibody for retargeting of T cells to tumor cells via the TCR co-receptor CD8.
... the CD8 co- receptor is normally not part of the T cell receptor ...the T cell receptor complex. As CD3 is not only part of the T cell receptor complex but directly involved in the creation ...
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Immunotherapy for Visceral Leishmaniasis: Ability of Factors Produced during Anti-leishmania Responses of Skin Test Positive Adults to Inhibit Peripheral Blood Mononuclear Cell Activities Associated with Visceral Leishmaniasis
... and CD8+ T suppressor (Ts) cell ...CD4+ T cell immunodominant responses against ...the CD8+ Ts cells associated with ...mononuclear cells derived from skin test posi- tive adults ...
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Efeito do exercício físico regular e intenso no sistema imune de idosos
... the T-cell subsets, increased percentages of effector memory T-cells and decreased percentages of terminally differentiated T-cells; higher proliferation of naive CD4+T ...
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Dysregulation of T lymphocyte proliferative responses in autoimmunity.
... T cells are critically dependent on cellular proliferation in order to carry out their effector ...uncontrolled T cell proliferation; however, in the murine model of autoimmune diabetes, hypo- ...
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CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA.
... reactive CD8 T cells was important for protection from the ...in T and B cells (Rag 2/2) to separate antiviral CD8 T cell activity from protective antibody ...polyclonal ...
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Uncovering the role of IFNAR1 in Experimental Cerebral malaria
... system cells that were then used in transfer ...the T cell profiles of C57BL/6 mice that received iRBC against mice that received irradiated iRBC (Figure ...that CD8 + T cells numbers ...
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Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.
... detection, cells were first stained for surface markers, fixed and permeabilized with Cytofix/ Cytoperm (BD Biosciences), then stained for intracellular markers for 30 minutes at 4 ...5 CD8 T cell ...
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CD8+ T cell control of HIV--a known unknown.
... that CD8+ T cell control of HIV infection acts via non-cytolytic mechanisms such as the production of cytokines and/or chemo- kines, and make that our new ...of CD8+ T cells to produce ...
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Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.
... and T cell cytotoxicity (Granzyme B expres- sion) in the ...+ CD8 + T cells were significantly reduced in the brain of infected PI3Kγ -/- mice when compared to infected wild type ...in ...
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Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines
... immune cells to elimi- nate tachyzoites of ...on CD8 T cells, it was plausible to assume that the IFN-γ was secreted in part by these ...
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