DNA Damage
Assessment of the DNA Damage in Human Sperm and Lymphocytes Exposed to the Carcinogen Food Contaminant Furan with Comet Assay
... The DNA is the critical target for lethal, carcinogenic, teratogenic and mutagenic effects of ionizing radiation and other environmental ...monitoring DNA damage, particularly in mammalian ...the ...
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Senescence of primary amniotic cells via oxidative DNA damage.
... induced DNA damage in amnion ...more DNA strand breaks compared to levels in unstimulated control cells (p ...prevented DNA strand damage by ,60% ...base damage was decreased to ...
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CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.
... cause DNA damage which promotes predominantly ATR activation, while b-amyloid peptide mainly stimulates ATM activity ...three DNA damaging agents, we hypothesized that the ATM/ATR pathway could be ...
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Evaluation of prevention of DNA damage and induction of DNA repair by natural compounds
... of damage. The balance between DNA damage-causing stress and DNA repair capacity is crucial for ...Once DNA damage is sensed the cell cycle is arrested so that molecular repair ...
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DNA damage and postural balance in multiple sclerosis patients
... evaluated DNA damage using the comet assay and the postural balance by dynamic posturography through six sensory organization ...between DNA damage index and two of the tests ...
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Recognition memory and DNA damage in undernourished young rats
... to DNA damage in leukocytes between marasmic undernourished children and a group of children in the eutrophic ...decrease DNA damage, data in agreement with the results of our study (for ...
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Metformin (dimethyl-biguanide) induced DNA damage in mammalian cells
... with DNA damage was higher when CHO-K1 cells were treated with both metformin con- centrations, although the frequency of DNA-strand breaks was only perceived at the lower concentration (Table ...as ...
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Thermodynamics of the DNA damage repair steps of human 8-oxoguanine DNA glycosylase.
... and DNA substrates during the catalytic cycles using fluorescence detection ...the DNA substrates have been detected during catalytic cycle at single-turnover ...the DNA complex with enzyme ...into ...
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DNA damage in children and adolescents with cardiovascular disease risk factors
... primary DNA damage, but they did not differ in terms of permanent DNA ...primary DNA damage ...permanent DNA damage, ...chromosome DNA damage in adults with ...
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DNA damage in canine transmissible venereal tumor cells
... placed into a horizontal electrophoresis unit filled with fresh alkaline buffer (1mM EDTA and 300 mM NaOH, pH>13) and left for 20 minutes. Then, electrophoresis was carried out for 20 minutes, at 25V and 300mA. At the ...
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Yeast transcription termination factor Rtt103 functions in DNA damage response.
... in damage response and other chromosomal functions since Rtt103 interacts genetically with a plethora of genes involved in chromatin or genome stability [38] For example, rtt103D show increased Rad52 foci, a mark ...
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Study of DNA damage induced by dental bleaching agents in vitro
... nification using a fluorescence microscope (Olym- pus, Orangeburg, USA) connected through a black and white camera to an image analysis system (Comet Assay II, Perceptive Instruments, Sufolk, Haverhill, UK). A ...
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DNA damage Evaluation in a Nursing Team Occupationally Exposed to Ionizing Radiation
... evaluate DNA damage in lymphocytes and cognitive deficits in a nursing team occupationally exposed to ionizing radiation in a university hospital in southern ...and DNA damage in lymphocytes ...
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Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate
... We analyzed the consequences of aerial spraying with glyphosate added to a surfactant solution in the northern part of Ecuador. A total of 24 exposed and 21 unexposed control individuals were investigated using the comet ...
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High consumption of sucrose induces DNA damage in male Wistar rats
... and DNA damage are typical findings in diabetic patients (Al-Aubaidy and Jelinek 2011, Binici et ...of DNA damage in blood cells and the sucrose ...of DNA damage in the ...
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Effects of melatonin on DNA damage induced by cyclophosphamide in rats
... CP-induced DNA damage in peripheral lymphocytes, additionally increased in the presence of ...oxidative damage induced by pinealectomy was also ...mobilizing DNA repair ...either DNA ...
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Key words: diazinon, Allium test, DNA damage, genotoxicty, RAPD-PCR
... Organophosphorous pesticides (OPs) posses a great potential of acute toxicity for exposed animals and men. To evaluate the toxic potential of the organophosphate diazinon on root meristematic cells of Allium cepa L., was ...
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Antimicrobial-induced DNA damage and genomic instability in microbial pathogens.
... antibiotic bleomycin, which binds DNA and directly induces double-strand breaks by a mecha- nism that is not fully understood [5]. Second, antimicrobials may interact with their target pro- tein in a manner that ...
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XRN2 Links Transcription Termination to DNA Damage and Replication Stress.
... Loss of XRN2 results in increased DSBs and genomic instability We next wished to examine a potential role for XRN2 in the DDR. For this, we employed an XRN2-specific shRNA to generate an immortalized human fibroblast ...
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DNA DAMAGE INDUCED BY ACRYLAMIDE: ROLE OF GENETIC POLYMORPHISMS IN DNA DAMAGE LEVELS Marta Sofia Pereira Pingarilho Fazendeiro
... Several reports have shown the sensitization potential of GSH depletion for the toxicity of physical and chemical agents (reviewed in [29]). As far as AA is concerned, there are few reports focusing on its toxicity in ...
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