ERK1/2
Neuronal differentiation dictates estrogen-dependent survival and ERK1/2 kinetic by means of caveolin-1.
... have demonstrated the link between the status of proliferation and differentiation and the different activation of ERK1/2. Caveolae are v-shaped lipidic rafts [41], located on the plasma membrane of many ...
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Tryptanthrin inhibits angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway.
... VEGFR2-mediated ERK1/2 signalling pathway in HMEC-1 cells and molecular docking simulation indicated that tryptanthrin could bound to the ATP-binding site of ...VEGFR2-mediated ERK1/2 ...
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Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.
... VEGF-A is a crucial regulator of embryonic and pathological hemangiogenesis. Inactivation of a single allele of VEGF-A in mice leads to lethality around embryonic day 11.5 because of severe defects in blood vessel ...
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Distinct pathways of ERK1/2 activation by hydroxy-carboxylic acid receptor-1.
... mediate ERK1/2 activation ...the ERK1/2 pathway mediated by angiotensin II type 1A (AT1A) [34], b2-adrenergic [35], vasopressin 2 [36], and parathyroid hormone (PTH) [37] receptors, ...
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Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells.
... by ERK1/2 phosphorylation in mouse fibroblast cells ...H 2 S and NAC protected PC12 cells against CoCl 2 -induced mitochondrial ...CoCl 2 , cells were treated with 600 mmol/L CoCl ...
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Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
... that ERK1/2 responds to different stimuli and mediates the expression and activation of c-Myc in a plethora of cell types; examples are AngII-induced c-Myc expression in astrocytes [51], and serum- or ...
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Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta
... tor, hydroxyflutamide (1 µmol/l) was used. To inhibit DHT-induced extracellular signal-regulated kinases (ERK)1/2 mitogen activated protein (MAP) kinase, p38 MAP kinase, or transforming growth factor (TGF)β ...
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Testosterona e Exercício Voluntário, Individualmente ou em Conjunto, Aumentam a Ativação Cardíaca de AKT e ERK1/2 em Ratos Diabéticos.
... Ao final do estudo, os tecidos cardíacos foram excisados e congelados em nitrogênio líquido imediatamente. Amostras de tecidos do ventrículo esquerdo foram armazenadas em temperatura de -70 °C até a medição de fosfo-AKT ...
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CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network.
... This study revealed a dose-dependent effect of CCN2 on collagen gene regulation. The stimulatory effects were only observed at low doses of CCN2, in the range of those induced by TGF-b, while at high doses CCN2 inhibited ...
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Aristolochia manshuriensis Kom inhibits adipocyte differentiation by regulation of ERK1/2 and Akt pathway.
... Aristolochia manshuriensis Kom (AMK) is a traditional medicinal herb used for the treatment of arthritis, rheumatism, hepatitis, and anti-obesity. Because of nephrotoxicity and carcinogenicity of AMK, there are no ...
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P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway.
... Cells were rinsed twice with ice-cold PBS and lysed in lysis buffer containing 20 mM Tris-HCl (pH 7.5), 250 mM NaCl, 4 mM EDTA, 0.5% NP-40, 20 mM β-Glycerophosphate, 1 mM NaF with protease inhibitors (Roche, Mannheim, ...
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The anti-apoptotic and cardioprotective effects of salvianolic acid a on rat cardiomyocytes following ischemia/reperfusion by DUSP-mediated regulation of the ERK1/2/JNK pathway.
... between ERK1/2 and JNK, with these reports focusing on tumor cells and immune response ...of ERK1/2-mediated Ser 446 in human cervical cancer cells and ...addition, ERK1/2 can ...
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Inhibition of ERK1/2 worsens intestinal ischemia/reperfusion injury.
... [β5]. ERK1/β has been shown to regulate the mTOR/p70S6K pathway ...of ERK1/β activity also suppressed the activity of p70S6K under our experimental Figure ...of ERK1/2 and p70S6K by U0126 ...
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Adiponectin Upregulates MiR-133a in Cardiac Hypertrophy through AMPK Activation and Reduced ERK1/2 Phosphorylation.
... reduced ERK1/2 phosphorylation in cardiomyocytes stimulated with Ang II, revealing a previously undemonstrated and important link between APN and ...
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ERK is involved in the reorganization of somatosensory cortical maps in adult rats submitted to hindlimb unloading.
... and ERK1/2 activation are activity-dependent phenomena (see above), a return to a normal amount of activity Figure ...increases ERK1/2 phosphorylation in layer II/III of the somatosensory ...
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Targeting Cell Division Cycle 25 Homolog B To Regulate Influenza Virus Replication
... and ERK1/2, both known targets of CDC25B phosphatase activity, were evaluated in mock- or influenza A/WSN/33 virus-infected BEAS2B cells in the presence or absence of ...and ERK1/2 proteins in ...
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Campylobacter jejuni pdxA affects flagellum-mediated motility to alter host colonization.
... Vitamin B6 (pyridoxal-5’-phosphate, PLP) is linked to a variety of biological functions in prokaryotes. Here, we report that the pdxA (putative 4-hydroxy-L-threonine phosphate dehydrogenase) gene plays a pivotal role in ...
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PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.
... (phospholylated) ERK1/2 was significantly reduced in all PTK6-gene-silenced pancreatic cancer cells compared to their corresponding control cells, while forced overexpression of PTK6 induced activation of ...
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Acidic environment leads to ROS-induced MAPK signaling in cancer cells.
... acidosis-induced ERK1/2 phosphorylation activates a rescue program preventing necrotic cell ...acidosis-induced ERK1/2 activation followed by necrosis takes place in all cell lines as a ...
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An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.
... and ERK1/2 ...increases ERK1/2 activation via a cholera toxin–sensitive pathway ...on ERK1/2 ...phosphorylated/total ERK1/2 that was used as an indicator of ...
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