HO-1
Genipin inhibits TNF-α-induced vascular smooth muscle cell proliferation and migration via induction of HO-1.
... by HO-1 knockdown. Our findings clearly demonstrate that HO-1 induction at least dominantly, if not totally, mediates genipin-induced deactivation of ...
11
Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2–HO-1 pathway in renal proximal tubular cells of transgenic mice
... and HO-1 protein expression in the RPTCs was observed in the kidney of Agt-Tg mice, implicating their possible role in the pathogenesis of hypertension and ...
12
Heme oxygenase-1 (HO-1) expression in prostate cancer cells modulates the oxidative response in bone cells.
... of HO-1 in the interaction between PC3 cells and bone, the main site of this disease ...with HO-1-induced PC3 cells decreased the expression of osteoclast-modulating factors in ...
14
Preoperative HO-1 levels as prognostic factor for adverse cardiac events in elder patients undergoing non-cardiac surgery.
... ventricular systolic dysfunction and it has been utilized in the diagnosis of acute coronary syndrome, heart failure, and other cardiac disorders. Research had examined its use as a biomarker for cardiac events in ...
6
Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2 -induced oxidative stress in mouse liver
... in HO-1 activation. The synthesis of HO-1 protein and the activation and translocation of Nrf2 were reported to be regulated by p38 ...of HO-1 also activated protein phos- ...
10
Regulation and novel action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1.
... Unexpectedly, we observed inhibition of the proliferation of NCI-H292 cells overexpressing TP in vitro and attenuation of their migratory potential. It was opposite to what has been observed in other tumor types ...
12
Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet.
... of HO-1 in mice fed a HFr ...of HO-1 ...of HO-1 attenuate adiposity in mice fed high-fat diet by reprogramming adipocyte phenotype to functional health adipocyte ...[55]. ...
22
Caracterização estrutural preliminar e efeitos na inflamação da lectina da alga marinha de Caulerpa cupressoides
... A HO-1 é uma enzima microssomal que catalisa a degradação do grupo heme em monóxido de carbono (CO), biliverdina (BVD) e ferro (ABRAHAM et ...de HO-1, a forma induzida da HO, resulta em ...
115
Proteção funcional da enzima heme-oxigenase-1 na lesão renal aguda isquêmica e tóxica.
... de HO-1 atenuou a lesão em ambos os modelos, enquanto que a administração do inibidor não demonstrou efeito significativo nessas ...de HO-1 nas lesões renais isquêmica e ...
4
Overexpression of Heme Oxygenase-1 Prevents Renal Interstitial Inflammation and Fibrosis Induced by Unilateral Ureter Obstruction.
... and HO-1 overexpression decreased the loss of ...by HO-1 may be associated with an increase in circulating endothelial progenitor cells derived from the bone ...whether HO-1 is ...
18
Heme oxygenase-1 deletion affects stress erythropoiesis.
... [3,4]. HO-1 facilitates iron reutilization in mammals [5] and modulates the expression of cytokines [6] and adhesion molecules ...[7,8]. HO activity has been implicated in the control of ...
8
Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis.
... The process of heme iron recycling after EP in macrophages is not completely understood. This is due in part to the use of various cellular models of EP which are described in the literature [3]. They are commonly based ...
13
Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina Orientador: Doutor Michel Kranendonk - FCMUNL
... que HO-1 funcionava como um monómero, no entanto um estudo anterior indicou que HO-1 se encontra em oligómeros no retículo endoplasmático, e que esses aglomerados são estruturalmente ...
88
Effects of heme oxygenase-1 recombinant Lactococcus lactis on the intestinal barrier of hemorrhagic shock rats
... the HO-1 expression increased significantly and the intestinal barrier was better after two LL-HO-1 ...the HO-1 protection is dependent on the HO-1 expression, and ...
6
Efeito inibitório do pré isquêmico a distância sobre a migração de neutrófilos : mecanismos e mediadores
... µmol/kg, ip)) em pré-tratamento de 30 min antes do PCI. Após peritonite, o sangue foi colhido e a expressão de CD11bem neutrófilos foi determinada por citometria de fluxo. Para análise estatística, utilizou-se ...
140
Perfil imunohistoquímico da expressão de ativadores com e sem pré com lalanilglutamina em modelo de isquemia e reperfusão em cérebros de gerbils
... diluição 1:200; anticorpo primário de rato monoclonal NF-kB, diluição 1:200; anticorpo primário de rato monoclonal HO-1 diluição 1:200 Santa Cruz® (o controle negativo não recebe ...
100
Repositório Institucional UFC: Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels
... Moreover, HO-1 can be modulated by cytokines, since the pro-inflammatory cytokines IL-1β and TNF-α down-reg- ulate this protein, whereas the anti-inflammatory cytokine IL-10 opposes such effect ...expressed ...
16
Modelo experimental de hipernocicepção facial e artrite na articulação induzida por zymosan em ratos e estudo da via da hemeoxigenase1bilidinamonóxido de carbono
... de HO- 1, TNFα e IL-1 no gânglio tigeminal, foi realizado estudo por imunohistoquímica em que se observou que tanto o corpo celular do neurônio aferente primário quanto as células satélites da glia ...
165
Rev. bras. farmacogn. vol.26 número2
... including HO-1, also pro- motes cell survival in oxidizing environments via enhancement of free radical metabolism, inhibition of cytokine-mediated inflam- mation, and recognition of damaged DNA (Surh et ...
7
A lectin from the green seaweed Caulerpa cupressoides reduces mechanical hypernociception and inflammation in the rat joint during zymosaninduced arthritis
... The slides were incubated with a secondary antibody LSAB Kit (DAKO®, Carpinteria, CA, EUA) for 10 min at ambient temperature. The slides were then incubated with a biotinylated goat anti-rabbit an- tibody diluted ...
10