ligand binding
Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site.
... putative ligand-binding ...any ligand to these extra ...the binding space in the canonical binding site is occupied by the b5-b6 loop of the neighboring molecule (Figure 1B and ...
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Electrostatically induced recruitment of membrane peptides into clusters requires ligand binding at both interfaces.
... ligand binding sites and the intracellular docking sites for G- protein both contain charges. These charges are conserved throughout the G protein-coupled receptor family. For example, negative charges are ...
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pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins.
... for binding sites on an ensemble of MD-sampled target ...and ligand competitive saturation ...membrane binding for their biological activity ...allosteric ligand binding site ...
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Exploring the composition of protein-ligand binding sites on a large scale.
... protein-ligand binding sites is of great importance to gain insight into the functional diversity of the ...valid binding site, helping the ligand maintain the correct binding mode and ...
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Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar Lonomia obliqua.
... Coupled oxidation of myoglobin has been found to differ mechanistically from the heme oxygenase reaction. Coupled Figure 4. Analysis of ligand binding to BBPLo. (a) Spectral analysis of BBPLo from L.obliqua ...
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Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure.
... identify ligand binding sites based on pocket ...identifying ligand binding sites from apo ...identifying ligand binding ...identifying ligand binding ...uncovering ...
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Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
... synthetic ligand that binds PPARd more than 300-fold more tightly than PPARa or PPARc but the structural basis of PPARd:GW0742 interactions and reasons for strong selectivity are not ...hormone binding ...
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Ligand photo-isomerization triggers conformational changes in iGluR2 ligand binding domain.
... molecule binding properties increases our understanding of the central nervous system and a variety of associated ...flexible ligand binding domains which undergoes large conformational changes upon ...
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Electron Transfer and Ligand Binding Properties of Cytochromes
... relative binding affinities of the ligands through electrostatic interactions with the nearby aminoacids and/or steric ...on binding that change the active/inactive state of the ...the ligand ...
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Low Resolution Structures of the Retinoid X Receptor DNA-binding and Ligand-binding Domains Revealed by Synchrotron X-ray Solution Scattering
... Nuclear receptors are ligand-inducible transcription factors that share structurally related DNA-binding (DBD) and ligand-binding (LBD) domains. Biochemical and structural studies have ...
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An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity.
... a ligand: Tyr342 forms a clamp near the base of the DII loop while Trp350, Trp353, Trp354, Pro355, and His357 all anchor the tip of the DII loop into the TgAMA1 apical groove (Fig ...of binding TgAMA1 in ...
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Structural dynamics of the cereblon ligand binding domain.
... The binding pocket is not formed and essentially all regions previously identified to be flexible are dramati- cally different from the thalidomide-bound conformation: In the first flexible region, the loop ...
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Proteomic-coupled-network analysis of T877A-androgen receptor interactomes can predict clinical prostate cancer outcomes between White (non-Hispanic) and African-American groups.
... the ligand-binding domain, that results in a receptor capable of promiscuous binding and activation by a variety of steroid hormones and ligands including estrogens, progestins, glucocorticoids, and ...
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Direct interaction between EgFABP1, a fatty acid binding protein from Echinococcus granulosus, and phospholipid membranes.
... that binding of FAs gives EgFABP1 significant relative protection against ...that ligand-binding results in a different exposure of proteolytic ...that binding of ligands involves ...
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GPCRDB: information system for G protein-coupled receptors
... Predicting the effects of mutations. We have started to create a service where users can predict the effects of a point mutation. As for now, predictions are mainly based on human knowledge that is stored in a computer ...
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Ionotropic Receptors Identified within the Tentacle of the Freshwater Snail Biomphalaria glabrata, an Intermediate Host of Schistosoma mansoni.
... conserved ligand-gated ion channel domain encoded by Pfam domains PF10613 and PF00060 ...The ligand-gated ion channel domain is made up of a combination of three transmembrane (TM) regions, an ion channel ...
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Structure of beta-cinnamomin, a protein toxic to some plant species
... In -CIN the dimer interface is based on a central core of hydrophobic interactions between residues located on helix 1 and on the beak-like motif, and one hydrogen bond between residues Thr77A and Ser20B. In the case of ...
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Geometric algorithms for cavity detection on protein surfaces
... Detecting and analysing protein cavities provides significant information about active sites for biological processes (e.g. protein– protein or protein–ligand binding) in molecular graphics and modelling. ...
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Mechanism of selective VEGF-A binding by neuropilin-1 reveals a basis for specific ligand inhibition.
... arginine binding cleft of the Nrp1-b1 domain is formed by three loops which are a common feature among coagulation factor ...this binding pocket differ between Nrp1 and Nrp2 and may contribute to the ...
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Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor.
... extracellular ligand binding, which promotes EGFR dimerization and ...activation. Ligand-binding measurements are consistent with a negatively cooperative model in which the ...
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