Mammalian target of rapamycin
Influência das HSPs (heat shock proteins) e do mTORC-1 (mammalian target of rapamycin...
... O objetivo deste trabalho foi contribuir para o melhor entendimento dos mecanismos intracelulares envolvidos na regeneração muscular esquelética, através do estudo da influência das proteínas de choque térmico (HSPs) e ...
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A new functional role for mechanistic/mammalian target of rapamycin complex 1 (mTORC1) in the circadian regulation of L-type voltage-gated calcium channels in avian cone photoreceptors.
... expression of L-VGCCs are significantly higher at night than during the ...mechanisms of circadian regulation of L- VGCCs in the retina are not completely ...mechanistic/mammalian ...
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Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through Mammalian Target of Rapamycin Signal Cascade.
... induction of endoplasmic reticulum stress to activate mammalian target of rapamycin (MTOR) ...association of metabolic syndrome with HBV-related HCC raises the possibility that ...
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Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy.
... models of temporal lobe epilepsy (TLE) indicates that dysregulation of the mammalian target of rapamycin (mTOR) pathway is involved in seizures and ...role of the mTOR ...
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The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway.
... regulators of synaptic development and underlie the interaction between epilepsy and ...The mammalian Target of Rapamycin (mTOR) modulates protein translation and is dysregulated in ...
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Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1).
... their rapamycin-sensitive proteins [48], just as we ...only rapamycin-sensitive phosphorylation events common to our dataset and theirs were the well-characterized ribosomal protein S6 ...a ...
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Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment.
... Exposure of mouse embryonic fibroblasts (MEF) to anti- cancer agents - such as doxorubicin or histone deacetylase inhibitors - also led to increased phosphorylation of eIF2α, albeit a sustained rather than ...
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Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners.
... Akt/mammalian target of rapamycin complex 1 (mTORC1) pathway is also suggested to be required for the type I IFN response to CpG-A in ...event of Akt, and can phosphorylate the ribosome ...
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Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma.
... expression of important proteins including vascular endothelial growth factor (VEGF-A), glucose transporter 1 (GLUT1), catalytic enzymes such as carbonic anhydrase IX (CAIX) and pro-apoptotic BCL-2/ adenovirus E1B ...
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Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury.
... Autophagy of postmitotic cells is an important protective mechanism that is essential for maintaining the homeostasis of ...model of passive Heymann nephritis and an in vitro model of ...
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Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice.
... acceleration of skeletal muscle senescence is less severe in female TauTKO than ...Treatment of metoformin, an anti- diabetic drug, extends lifespan in female mice but not male ...[50,51]. Target ...
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Resistance exercise: A non-pharmacological strategy to minimize or reverse sleep deprivation-induced muscle atrophy
... activity of synthetic pathways over degradation pathways results in muscle fiber hypertrophy, and the opposite situation results in muscle atrophy ...activation of translation factors (eukaryotic ...
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The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
... combination of mammalian target of rapamycin (mTOR) inhibitor RAD001 (everolimus) and Akt inhibitor MK-2206 exerted synergistic cytotoxic effects against low-phosphatase and tensin ...
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Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
... objective of the present study was to assess the effects of the immunosuppressant rapamycin (Rapamune ® , Sirolimus) on both resistance vessel responsiveness and atherosclerosis in apolipoprotein ...
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Rev. Bras. Cardiol. Invasiva vol.22 número4
... cases of occurrence of some adverse event, assessments were performed directly in the documentation-source, and subsequently adjudicated by the independent Clinical Events ...sisted of morphology ...
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LITERATURE AS A FACILITATOR OF TARGET CULTURE LEARNING
... terms of style, and way of ...the target culture facilitates the learning process of any foreign language because any language does not involve only lexical structures to establish ...studies ...
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Drug-induced regulation of target expression.
... development of drug ...analysis of drug- induced differential expression of drug targets using the Connectivity Map, a resource that contains the genome- wide expression profiles of 1309 ...
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Interaction between attention and bottom-up saliency mediates the representation of foreground and background in an auditory scene.
... aspects of our environment while ignoring ...object of attention) from unattended clutter, or ...basis of this phenomenon by engaging listeners to attend to different components of a complex ...
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Three-dimensional computer modeling of birds proepicardium on different stages of embryogenesis
... Myocardial heterogeneity in permissiveness for epicardium-derived cells and endothelial precursor cells along the developing heart tube at the onset of coronary vascularization / Heleen Lie-Venema, Is- mail Eralp, ...
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A hybrid model of mammalian cell cycle regulation.
... elegance of the Boolean representation of the switching network, while introducing continuous variables for cell size, cell age, and cyclin composition, in order to create a model that can be compared in ...
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