Merozoite surface protein 1
Serological detection of Plasmodium vivax malaria using recombinant proteins corresponding to the 19-kDa C-terminal region of the merozoite surface protein-1
... Background: Serological tests to detect antibodies specific to Plasmodium vivax could be a valuable tool for epidemiological studies, for screening blood donors in areas where the malaria is not endemic and for diagnosis ...
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Molecular identification of a malaria merozoite surface sheddase.
... Plasmodium merozoite enters its host cell by an active invasion process that is mediated by adhesive receptor–ligand interactions and driven by an actinomyosin motor ...the merozoite such that its apical ...
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Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens.
... vivax merozoite surface protein 1 (pvmsp-1) and Plasmodium vivax circumsporozoite protein ...to merozoite antigens from ...
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Seleção e desenvolvimento de adjuvantes para uso em imunizações com proteínas recombinantes de Plasmodium
... Recently, we generated two bacterial recombinant proteins expressing 89 amino acids of the C-terminal domain of the Plasmodium vivax merozoite surface protein-1 and the hexa-histidine tag (His ...
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Érika Martins Braga, Melissa da Silva Bastos, Gerhard Wunderlich, José Rodrigues Coura
... the merozoite surface protein (MSP)-1 of both Plasmodium vivax (PvMSP-1 19 ) and Plasmodium falciparum (PfMSP-1 19 ) in remote malaria-exposed populations of the Amazon ...
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BM5 - SEQUENCE DIVERSITY, ANTIBODY RECOGNITION AND EVOLUTION OF THE MALARIA VACCINE CANDIDATE ANTIGEN MEROZOITE SURFACE PROTEIN-2 (MSP-2) OF PLASMODIUM FALCIPARUM
... from non-normalized and normalized cDNA libraries of CL Brener epimastigotes (Urmenyi et al., 1999) and were kindly provided by Dr. W. Degrave and Dr. A. Brandão (FIOCRUZ, Rio de Janeiro, Brazil). Search for similarity ...
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A multifunctional serine protease primes the malaria parasite for red blood cell invasion
... portant merozoite surface molecules and so effectively prim- ing the parasite for ...site 1 occurs faster than cleavage at site 2, a distinction shared by peptide substrates based on these sites ...
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Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2.
... Previous studies of structured antigens have established that increased epitope flexibility tends to increase antigenicity [65,66], in contrast to the current findings. An important distinc- tion is that these studies ...
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Expression and Evaluation of Recombinant Plasmodium knowlesi Merozoite Surface Protein-3 (MSP-3) for Detection of Human Malaria.
... genes [1]. Ethical approval for this study was obtained from the University of Malaya Medical Centre Ethic Committee (MEC Ref. No. 817.18) and informed verbal consent from the donor or the next of kin was obtained ...
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Antigenicity and Immunogenicity of Plasmodium vivax Merozoite Surface Protein-3
... 1 Departamento de Ana´lises Clı´nicas e Toxicolo´gicas, Faculdade de Cieˆncias Farmaceˆuticas, Universidade de Sa˜o Paulo, Sa˜o Paulo, Brazil, 2 Departamento de Gene´tica, Evoluc¸a˜o e Bioagentes, Instituto de ...
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Evaluation of nanoporous materials for biotoxin capture
... high surface area, a very good stability in several solvents, including organic solvents and some even in water, tunable structures and pore size, low density, high pore homogeneity, versatile building units, high ...
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Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.
... Cells were washed two times with PBS, placed in lysis solution (1% Nonidet P-40 containing 2 mM phenylmethylsulfonyl fluo- ride, 10 m g/ml aprotinin, 2 m g/ml, pepstatin, 10 mM iodoaceta- mide, 0.1 mM EDTA, 0.1 mM ...
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Understanding ion exchange chromatography adsorption mechanisms under different conditions
... the protein electrical double layer ...the protein must be partially ...a protein increases with size and exposed hydrophobicity surface ...
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Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi.
... through surface-exposed lipoproteins, collec- tively called ‘‘CRASPs’’ (complement regulator-acquiring surface proteins) ...Each protein has different relative affinity for each of the three human ...
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Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome
... In GO function annotation, some genes involved with regulation of neurological system processes were enriched in Down syndrome samples. Also, during KEGG pathway annotation, there were some genes related to Alzheimer’s ...
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Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 –
... It has been demonstrated that Mipu1 has a high expression in rat heart and is mainly located in the nuclei of H9c2 myogenic cells (25). The expression pattern and nuclear localization suggest that Mipu1 plays a role in ...
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Protein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1.
... chameleon protein that is able to adopt distinct conformations in a way independent of mutations ...same surface of the ATX1 AXH domain can host palindromic interactions that determine partner recognition ...
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Severe malaria and Plasmodium
... the surface of the syncytiotrophoblast, thereby providing a clear advantage over previous cell models or commercial CSA preparations from various non-placental sources ...the surface of endo- thelial ...
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Malaria parasite invasion of the mosquito salivary gland requires interaction between the Plasmodium TRAP and the Anopheles saglin proteins.
... Plasmodium protein with similarity to the peptide, we reasoned that SM1 conformation, rather than primary amino acid sequence, is related to a sporozoite ...essential protein for gliding motility and ...
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Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway.
... Impairment of endothelium-dependent vasodilatation has been described in diabetic patients [25,26] and animal models of diabetes and spontaneous hypertension [18,24,27]. It has been reported there is a close relationship ...
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