Motor neuron degeneration
Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
... Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by a progressive loss of lower motor neurons in the spinal cord. The incretin hormone, glucagon-like peptide-1 (GLP-1), ...
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Arq. NeuroPsiquiatr. vol.70 número7
... upper motor neuron degeneration in amyotrophic lateral sclerosis/primary lateral sclerosis or merely a useful paraclinical tool to exclude mimic syndromes? A critical review of imaging applicability ...
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Arq. NeuroPsiquiatr. vol.73 número4
... upper motor neuron degeneration in amyotrophic lateral sclerosis/primary lateral sclerosis or merely a useful paraclinical tool to exclude mimic syndromes? A critical review of imaging applicability ...
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Exploring deregulated signals involved in Motor neuron-Microglia cross-talk in ALS
... of motor neuron degeneration in ALS, one of the most recent proposals to therapy concerning neurodegenerative disorders is replacement of microglial cells (Cartier et ...protect motor neurons ...
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Arq. NeuroPsiquiatr. vol.75 número5
... Despite all this clinical and etiopathogenic complexity, some faces of ALS, including FTD-MND continnum, have been elucidated by magnetic resonance imaging (MRI) techniques, which have proved to be useful to reveal ...
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Arq. NeuroPsiquiatr. vol.73 número12 X anp X20150161
... upper motor neuron degeneration in the frontal lobe (mainly Betz giant cells in the motor cortex), corticospinal and corticobulbar tracts (in the spinal cord, internal cap- sule and cerebral ...
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Arq. NeuroPsiquiatr. vol.68 número2
... “motor neuron diseases” which encompasses other clinical entities such as progressive spinal atrophy, progressive bulbar atrophy and primary lateral ...
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Fernanda Marques de Souza Godinho 1,2 , Hugo Bock 1,2 , Tailise Conte Gheno 1,3 and Maria Luiza Saraiva-Pereira 1,2,3,4
... Spinal muscular atrophy (SMA) is a genetic disorder characterized by symmetric proximal muscle weakness due to degeneration of the anterior horn cells of the spinal cord. Based on the severity of symptoms and age ...
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Rev. Bras. Anestesiol. vol.67 número6
... It is transmitted from mother to child, by sexual contact, blood transfusions, or sharing contaminated needles. Two diseases are associated with this infection: adult T-cell leukemia/lymphoma (ATL) and tropical spastic ...
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Action potential energy efficiency varies among neuron types in vertebrates and invertebrates.
... each neuron is using its combination of channels to produce its particular ...leg motor neuron axon, CA [9], a mouse (Mus musculus) fast spiking GABAergic cortical interneuron, MFS [10], a worker ...
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Arq. NeuroPsiquiatr. vol.75 número4
... Acute muscle weakness in children is a pediatric emergency. During the diagnostic approach, it is crucial to obtain a detailed case history, including: onset of weakness, history of associated febrile states, ingestion ...
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Arq. NeuroPsiquiatr. vol.73 número3
... cellular degeneration and system level degeneration have been better elucidated, providing a roadmap for devel- oping novel treatments based on specific targeting of gene ...
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J. Pediatr. (Rio J.) vol.86 número4 en a04v86n4
... prepublication for the journal Neurology of Disease, showed that cultures of motor neurons from mice with SMA I that were treated with valproic acid also increased SMN protein expression. However, unexpectedly, ...
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Facial grimacing as a clue for the diagnosis of GM1 type 3 gangliosidosis
... his report highlights that unusual phenotypes such as an ataxia-parkinsonism-motor neuron disease syn- drome may be found in SCA 2 individuals. his raises several questions such as whether or not patients ...
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Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
... Impaired proteasome function has been implicated in neurode- generative disorders including FTLD-U and ALS, resulting in decreased clearance of mislocalized and misfolded proteins [43]. Given that only proteasome ...
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Arq. NeuroPsiquiatr. vol.59 número3A
... recorded and she scored 26 points at the MMSE, with a poor performance on motor tasks because of ideomotor and constructive apraxias. Left side parkinsonism was present and the AHS appeared one year later. It was ...
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Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study.
... lower motor neuron signs) [32]. Patients with a progressive lower motor neuron disorder with no upper motor neuron signs were classified as having sporadic progressive muscular ...
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Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy.
... positive motor neurons, Tuj1 positive neurons, and GFAP positive astrocytes ...HB9 motor neuron-specific promoter in iPSCs in conjunction with co-culture assays will address this ...
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Transplantation of Xenopus laevis tissues to determine the ability of motor neurons to acquire a novel target.
... a motor neuron to reroute to target a novel tissue that is transplanted into its trajectory; however, the nervous system is not completely plastic and not every motor neuron can interact with ...
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Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord.
... injury. Neuron-restricted precursor cells differentiate into mature neuronal subtypes when transplanted into adult non-injured spinal cord, but fail to differentiate when transplanted into injured spinal cord ...
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