Mouse model
Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
... Low bone mass and increased fracture risk are recognized complications of cystic fibrosis (CF). CF-related bone disease (CFBD) is characterized by uncoupled bone turnover—impaired osteoblastic bone formation and enhanced ...
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BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease.
... We began our studies asking whether vaccination with tyrosine hydroxylase (TH), a neuronal protein involved in dopamine synthesis, could protect striatal dopaminergic neurons to a greater extent than CopaxoneH in the ...
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Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions.
... clinically [30,32,61]. L-838,417, thought to be non-sedative compared with other clinically effective BZDs [62], indeed reduced fear expression in HAB mice. At this stage it should be mentioned that we cannot completely ...
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FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia.
... 1-month-old mouse tissues (as shown in Fig 1C and 1D) in order to preempt any phenotypic manifestations in the YG8sR mouse and thus potentially representing all cell types including those that would be lost ...
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A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection
... animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective ...a mouse model in which bacteria are ...
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Neuropathologic study of a transgenic mouse model of Machado-Joseph disease
... Machado-Joseph Disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the ATXN3 gene product, ataxin-3 protein. Clinically, MJD is a ...
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Intact olfaction in a mouse model of multiple system atrophy.
... transgenic mouse model with targeted oligoden- droglial overexpression of haSYN driven by the PLP promoter [14] featuring MSA-like inclusion ...mouse model. This finding is in contrast to a ...
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Restoring retinal function in a mouse model of hereditary blindness.
... mice show an early onset rod–cone dystrophy and, as in the human disorder, have disease confi ned to the eye. The mouse model appears to faithfully reproduce the phenotype seen in humans with Lrat defi ...
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Analgesic effects of lappaconitine in leukemia bone pain in a mouse model
... Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic ...
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Anti-CD3 Antibody Ameliorates Transfusion-Associated Graft-Versus-Host Disease in a Chemotherapy-Based Mouse Model With Busulfan and Fludarabine
... a mouse model relevant to clinical practice, we combined the chemo-reagent busulfan and the nucleotide analog fludarabine, which are common drugs used to condition patients undergoing bone marrow ...
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Mangiferin ameliorates the intestinal inflammatory response and the impaired motility in mouse model of postoperative ileus
... Mangiferin (1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy- 6-(hydroxymethyl)oxan-2-yl]xanthen-9-one) (MGF) is a nat- ural polyphenol found in many plant species, among which the mango tree (Mangifera indica) is one of the ...
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A mouse model of the human Fragile X syndrome I304N mutation.
... Syndrome mouse model in which the endogenous Fmr1 gene harbors the I304N ...null mouse, as assessed by testicular size, behavioral phenotyping, and electrophysiological assays of synaptic ...new ...
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Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.
... First, the physical interaction between MeCP2 and its interacting partners identified in our study are independent of any nucleic acid, suggesting that MeCP2 does not need to bind to RNA in order to regulate splicing. ...
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Eeyore: a novel mouse model of hereditary deafness.
... novel mouse model of non-syndromic sensorineural hearing loss with linkage to a region on chromosome ...new model of hereditary sensorineural deafness and will be an important tool in the search for ...
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Allergen-Specific Immunotherapy with Monomeric Allergoid in a Mouse Model of Atopic Dermatitis.
... Atopic dermatitis (AD) is a widespread and difficult to treat allergic skin disease and is a tough challenge for healthcare. In this study, we investigated whether allergen-specific immunotherapy (ASIT) with a monomeric ...
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Prostatic inflammation induces fibrosis in a mouse model of chronic bacterial infection.
... There is accumulating evidence for the contribution of increased collagen deposition and fibrosis to the pathogenesis of BPH/LUTS [3–5,62]; however, the underlying cause of increased collagen deposition in this common ...
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A new mouse model to study acquired lymphedema.
... new model provides opportunities to identify sets of genes previously unsuspected to be involved in acquired ...tadpole model of lymphangiogenesis, may accelerate the functional screening of such candidates ...
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Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression.
... Mood disorders are one of the most prevalent causes of disability worldwide and depression is diagnosed in women at roughly twice the incidence of men in the general population [5,6]. While HD is an autosomal dominant ...
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A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.
... the mouse model then those normally clini- cally administered to ensure the development of late cerebral RN in all ...this mouse model truly illustrates late-onset injury, which is a hallmark ...
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Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model
... Moreover, because the MWF is defined as a fraction of total water in a voxel, it is obvious that a change in the absolute amount of IE-water will by definition change the MWF, although there has been no change in the ...
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