Multidrug resistance
The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.
... It is striking that of the core set of Mrr1p target genes (i.e., the 14 genes that were upregulated by the mutated MRR1 alleles in the SC5314 background as well as upregulated in the drug-resistant isolates F5 and G5 and ...
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Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance.
... Multidrug resistance (MDR) is a major impediment to curative cancer ...mitoxantrone resistance due to its dramatic sequestration in ...level resistance to topotecan, imidazoacridinones and ...
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NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance.
... of resistance to chemotherapy [2]. The inevitable development of multidrug resistant cancer cells during the course of treatment is a major fundamental obstacle associated with cancer ...cross ...
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Identification of microRNAs and mRNAs associated with multidrug resistance of human laryngeal cancer Hep-2 cells
... Multidrug resistance (MDR) poses a serious impediment to the success of chemotherapy for laryngeal ...a multidrug-resistant human laryngeal cancer subline, designated Hep-2/v, by exposing Hep-2 cells ...
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Expression of P-glycoprotein, multidrug resistance-associated protein, glutathione-S-transferase pi and p53 in canine transmissible venereal tumor
... of multidrug resistance (MDR) (Di Pietro et ...cross resistance to seve- ral other compounds unrelated structurally or functionally (Thomas & Coley ...Drug resistance may be related to ...
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P-glycoprotein and multidrug resistance: structure-activity relationships of modulators.
... AND MULTIDRUG RESISTANCE: STRUCTURE-ACTIVITY RELATIONSHIPS OF ...MODULATORS. Multidrug resistance, MDR is a major obstacle for cancer ...
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The Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding Domains.
... ABC transporters are integral membrane pumps that are responsible for the import or export of a diverse range of molecules across cell membranes. ABC transporters have been impli- cated in many phenomena of medical ...
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Integron mediated multidrug resistance in extended spectrum beta-lactamase producing clinical isolates of Klebsiella pneumoniae
... not resistance genes are contained within the integrons, the results presented here indicate wide dissemination of ARIs in ESBL producing ...drug resistance rates as well as multidrug resis- ...
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Determination of multidrug resistance mechanisms in Clostridium perfringens type A isolates using RNA sequencing and 2D-electrophoresis
... a multidrug-resistant isolate strain of Clostridium perfringens by RNA ...in multidrug resis- tance (MDR) in the isolate strain: drug transport, drug response, hydrolase activity, transmembrane transporter, ...
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Modulation of P-Glycoprotein Mediated Multidrug Resistance (Mdr) in Cancer Using Chemosensitizers.
... of resistance to a wide spectrum of drugs occurred through a variety of ...of multidrug resistance ...drug resistance, the best-studied mechanism of MDR is related to the over expression of ...
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Antineoplastic therapy - multidrug resistance
... Multidrug resistance (MDR) in oncology stand as one of the main challenges in clinical treatment, as a result of several concomitant yet different mechanisms developed by carcinoma stem cells ...multiple ...
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The master activator of IncA/C conjugative plasmids stimulates genomic islands and multidrug resistance dissemination.
... Schematic representation of SGI1 from S. enterica Typhimurium DT104 and MGIVmi1 from V. mimicus VM573. The left and right junctions (attL and attR) within the host chromosome are indicated. SGI1 (42 596 bp, Genbank ...
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Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer.
... tidrug resistance, through regulation the expression level of multidrug resistance protein, such as P-glycoprotein(ABCB1) and MRP1(ABCC1) ...ABCG2-mediated multidrug resistance in colon ...
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Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa
... unknown. Multidrug-resistance protein (MRP)–like adenosine triphosphate (ATP)–binding cassette transporters are known to be related to multidrug resistance in many ...
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Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus
... quinolone resistance level, previously correlated with an increased efflux activity, which was also associated with increased resistance to biocides and ...
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Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR.
... low-level resistance to last-line agents such as vancomycin and ...vancomycin resistance was experi- mentally confirmed using bi-directional allelic exchange experi- ...
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The Age of Multidrug Resistance: Ten Year Incidence in a Neonatal Intensive Care Unit
... No entanto, ao comparar a taxa de letalidade por BMR (10,9%) calculada no presente estudo com a taxa de mortalidade global (4,4%) e com a taxa de letalidade por infeções assoc[r] ...
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The role of the efflux mechanisms in multidrug resistance in Mycobacterium tuberculosis
... macrolide resistance in reference and clinical MAC strains isolated from AIDS ...high-level resistance also results from efflux activity, as already suggested by the reduction of MICs for clarithromycin and ...
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Positive Epistasis Drives the Acquisition of Multidrug Resistance
... antibiotic resistance but also reveal an extra layer of complexity on epistatic patterns previously unpredicted, since it is hidden in genome-wide studies of genetic interactions using gene ...antibiotic ...
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Multidrug resistant bacteria isolated from septic arthritis in horses
... drug resistance of ...high resistance rate (>70% resistance) was observed to penicillin ...considered multidrug resistant ...the multidrug resistance of ...with ...
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