NF-κB
p-cresol mas não p-cresil sulfato estimulam a produção de MCP-1 via NF-κB p65 em células vasculares musculares lisas humanas.
... Reconhecemos que o presente estudo apresenta algumas limitações e que mais trabalhos se fazem necessários. Em primeiro lugar, há outras vias de ativação e subunidades do NF- κB imbricadas na expressão de ...
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Effects of Cinnamon extract on biochemical enzymes, TNF-α and NF-κB gene expression levels in liver of broiler chickens inoculated with Escherichia coli
... E. coli is one of the major bacteria causing burden to poultry industry. Pathogenic E. coli can cause colibacillosis, a local or systemic disease which in very acute and serious form may lead to the septicemia and ...
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TLR2 ligands induce NF-κB activation from endosomal compartments of human monocytes.
... neither TNF nor IL-6 in response to high dose of LPS [β5], and that, pharmacological inhibition of TRAM and endocytosis impaired NF-κB activation and IL-6 production in LPS-treated cells [β,β6]. With regard ...
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Resveratrol attenuates CoCl2-induced cochlear hair cell damage through upregulation of Sirtuin1 and NF-κB deacetylation.
... Silence information regulation 1 (Sirt1), a NAD-dependent histone deacetylase, is extensively expressed in the cytoplasm and nucleus. Sirtuin1 plays an important role in cellular transcription and metabolism, and it has ...
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Resveratrol Attenuates LPS-induced Apoptosis via Inhibiting NF-κB Activity in Chicken Peripheral Lymphocyte Cultures
... of NF-κB, and consequently downregulated the transcription and biological syntheses of Fas and Caspase-8, leading to the protection of the chicken peripheral lymphocytes from LPS-induced ...
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A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice.
... of NF-κB in a number of cancers, and the lack of clarity regarding the role of NF-κB in skin carcinogenesis, we examined the tumorigenic potential of skin with enhanced NF-κB ...
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Quantification of cellular NEMO content and its impact on NF-κB activation by genotoxic stress.
... induce NF-κB signaling in response to genotoxic agents (reviewed in ...of NF-κB sig- naling [16–18], it is important to control the amount of NEMO expressed in different cell systems in order ...
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Targeting the NF-κB Pathway as a Combination Therapy for Advanced Thyroid Cancer.
... Increased NF-κB signaling in cancer cells is known to block apoptosis ...[30]. NF-κB pathway inhibition has been shown to sensitize cells to the pro-apoptotic effect of TNFα ...drug/ ...
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Effect of Wntβ-catenin and NF-κB Signaling Pathways on Mucus Secretion with Hypertonicity in 16HBE Cells
... One day before the transfection, the cells were plated in growth medium without antibiotics per well. Therefore, they were 90–95% confluent at the time of transfection. Next, the cells were transfected with siRNA (either ...
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Alternative NF-κB Isoforms in the Drosophila Neuromuscular Junction and Brain.
... Drosophila NF-κB protein Dorsal is expressed at the larval neuromuscular junction, where its expression appears unrelated to known Dorsal functions in embryonic patterning and innate ...insect ...
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Roles of PPARγ/NF-κB signaling pathway in the pathogenesis of intrahepatic cholestasis of pregnancy.
... with NF-kB, causing inhibition of its signaling pathway or reducing the activated levels of NF-kB and subsequent inflamma- tion ...and NF-kB [33,34]. PPARc could inhibit activation of NF-kB ...
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Celastrol blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cells.
... the NF-kB response element within IL-6 promoter area since mutation of the NF-kB response element from AAATGTCCCATTTTCCC to AAATGTTACATTTTCCC by site-directed mutagenesis abolished the inhibition of ...
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Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-κB regulated ATM expression.
... the NF-kB pathway ...putative NF-kB binding sites in the ATM promoter ...the NF-kB pathways, which resulted in the change of radiosensitivity in ...the NF-kB pathway and inhibition of LMP1 ...
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Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation.
... factor NF-kB, a property that is essential for EBV-transformed lymphoblastoid cell ...higher NF-kB activation levels compared to the prototype B95-8 LMP1 by some ...LMP1-mediated NF-kB activation ...
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IKKε knockout prevents high fat diet induced arterial atherosclerosis and NF-κB signaling in mice.
... of NF-kB dimers, the P65/P50 heterodimer is the most common form and plays the most important role in the activation of downstream targeted genes ...activate NF-kB ...as NF-kB, interferon regulatory ...
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The synergistic repressive effect of NF-κB and JNK inhibitor on the clonogenic capacity of Jurkat leukemia cells.
... of NF-kB signaling alone might not be sufficient to eliminate most leukemic cells because other survival/proliferative signaling might be also activated by these oncogenic mutations and microenvironmental ...when ...
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The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB.
... The fungal and the animal kingdom are related as they both belong to the ophistokonts with a common ancestor existing about 1 billion years ago [1,2]. Animals have evolved with an elaborate inflammation and immune system ...
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Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation.
... the NF-kB system is that perturbation of its functions can have broad deleterious ...of NF-kB function through targeted inactivation of critical components, such as Rel or IkB kinase (IKK-a and -b) genes, ...
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Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice.
... Another interesting finding of this study is the improvement in renal lipid metabolism by celastrol treatment. In diabetic mice, mRNA expression levels of enzymes involved in cholesterol synthesis, such as HMG-CoA ...
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Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagy.
... The omega-3 (v3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1b production through poorly understood molecular mechanisms. Here, we show that DHA reduces macrophage IL-1b production ...
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