NMDA receptors
Localization of NMDA receptors in the cerebral cortex: a schematic overview
... NMDA receptors are preferentially ex- pressed by pyramidal ...paragraph, NMDA receptors are pref- erentially located on dendritic spines, which is a typical, though not exclusive, attribute of ...
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Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors.
... of NMDA receptors on PFC neurons that provide top-down control of VTA DA neuron ...As NMDA-mediated EPSCs in mutant mice were clearly less inhibited by intoxicating concentrations of ethanol as ...
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Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons.
... network, NMDA receptors are abundant at the recurrent synapses but scarce at the mossy fiber ...which NMDA receptors were abolished in hippocampal CA3 pyramidal neurons by postnatal day ...
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Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment.
... that NMDA antagonists, like ketamine, exert an antidepressant effect at preclinical and clinical ...the NMDA receptor complex, in adult rats, and to establish whether concomitant antidepressant treatment ...
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The A-current modulates learning via NMDA receptors containing the NR2B subunit.
... dendritically, where they act as crucial regulators of postsynaptic excitability [9–11] and modulators of synaptic plasticity [12–17]. DREAM is a multifunctional Ca 2+ -binding protein of the EF-hand subfamily of ...
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An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.
... NMDA receptors (NMDARs) form glutamate-gated ion channels that play a critical role in CNS physiology and ...kainate receptors, NMDARs are known to operate as tetrameric complexes with four membrane- ...
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MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
... The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs), are im- portant for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, ...
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Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats
... postsynaptic NMDA receptors in a RVLM neuron (NOS ...both NMDA and AMPA receptors to promote cardiovascular responses however, NO selectively modulate NMDA receptors in the RVLM ...
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In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer ’s disease
... these receptors [28]. Molecular docking was performed for NMDA receptors for both humans and ...the receptors in order to let them bind freely anywhere on the ...
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Palmitoylation at two cysteine clusters on the C-terminus of GluN2A and GluN2B differentially control synaptic targeting of NMDA receptors.
... Palmitoylation of NMDARs occurs at two distinct cysteine clusters in the carboxyl-terminus of GluN2A and GluN2B subunits that differentially regulates retention in the Golgi apparatus and surface expression of NMDARs. ...
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N-Methyl D-Aspartic Acid (NMDA) Receptors and Depression
... through NMDA receptor. Both standard antidepressants and NMDA receptor antagonists are able to prevent stress-induced neuronal ...damage. NMDA antagonists are effective in widely used animal models ...
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Characterisation of the expression of NMDA receptors in human astrocytes.
... express receptors capable of responding to endogenous neurotransmitters has resulted in the need to reassess astrocytic ...of NMDA receptors (NMDARs) in primary human astrocytes, and investigate ...
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Role of NMDA receptors in the trigeminal pathway, and the modulatory effect of magnesium in a model of rat joint arthritis
... of NMDA-R ...reduced NMDA-mediated hyperalgesia induced by peripheral injury (34), and NR1 subunit knockout mice exhibited a reduction in hypernociception and allodynia ...
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Current and calcium responses to local activation of axonal NMDA receptors in developing cerebellar molecular layer interneurons.
... Axonal Ca 2+ Responses to Local NMDAR Activation Next we tested whether local axonal glutamate uncaging (Fig. 5A, blue arrowhead) could produce Ca 2+ transients that would be associated with the current responses. Local ...
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The Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor Activation.
... Hippocampal GRs were significantly decreased both early (24 h) and long after (1 month) pilocarpine treatment. These effects have parallels to studies in which rats exposed to a single prolonged stress also show ...
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Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons.
... Sensory and motor information processed by the cortex and thalamus passes through the striatum where it is modulated by two largely antagonistic classes of MSNs that express distinct dopamine receptors and ...
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NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization.
... the NMDA component could be obtained by subtracting the AMPA current remaining after AP5 application from the control current, as ...the NMDA current was ...Average NMDA current measured as described ...
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Electrophysiological evidence for the presence of NR2C subunits of
... non- NMDA ionotropic receptors in second-or- der neurons within the NTS ...of NMDA and non-NMDA recep- tors in synaptic transmission in the NTS is not well ...non-NMDA receptors ...
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Clinics vol.66 suppl.1
... by NMDA receptors. A hypofunction of the NMDA receptor bearing on inhibitory GABAergic interneurons gives rise to reduced GABAergic inhibitory ...cholinergic receptors with subsequent cell ...
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Arq. NeuroPsiquiatr. vol.66 número4
... – NMDA and non-NMDA receptors are involved in spinal transmission of nociceptive information in physiological and pathological ...of NMDA and non- NMDA receptor antagonists on pain ...
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