PI3K–AKT signaling
Photofrin based photodynamic therapy and miR-99a transfection inhibited FGFR3 and PI3K/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo.
... Glioblastoma is the most common malignant brain tumor in humans. We explored the molecular mechanisms how the efficacy of photofrin based photodynamic therapy (PDT) was enhanced by miR-99a transfection in human ...
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The role of PI3K/AKT signaling on the formation of the epaxial myotome of the mouse (Mus musculus) embryo
... the PI3K/Akt pathway, a pathway which has been shown to be involved in a multitude of cellular signaling processes, including promoting differentiation and conferring differentiating cells a ...
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Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling.
... Citation: Gherzi R, Trabucchi M, Ponassi M, Ruggiero T, Corte G, Moroni C, et al. (2015) Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT ...
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Selenium protects against LPS-induced MC3T3-E1 cells apoptosis through modulation of microRNA-155 and PI3K/Akt signaling pathways
... the PI3K/Akt signaling is an important pathway involved in preventing MC3T3-E1 against oxidative stress and apop- tosis (Jin et ...of PI3K/Akt signaling ...phosphorylated ...
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K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis.
... Since hematopoietic stem cells and angioblasts originate from bipotential precursors and thus the blood and blood vessel formation are closely connected in early stage [13], we set out to examine if the ...
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Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes.
... PIγK/Akt signaling seems to dominate this effect and the subsequent Epo/VEGF ...baicalein-activated Akt via class I PIγK does not contribute to its Epo/VEGF-inducing effect while the effect was ...
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Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.
... PI3K/Akt signaling pathway plays a major role in the control of cell proliferation, survival, metabolism and nutrient uptake in a cell-type-specific manner through a variety of downstream targets ...
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IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway.
... the PI3K/Akt signaling pathway, in turn leads to upregulation of the key transcription factor Brn-4, thereby promoting NSCs differentiation along neuronal ...
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ANÁLISE DA ALTERAÇÃO DO NÚMERO DE CÓPIAS DE GENES ENVOLVIDOS NA VIA DE SINALIZAÇÃO CELULAR EGFR/PI3K/AKT/PTEN EM CÂNCER PENIANO.
... require PI3K/Akt signaling for their survival, and this is often achieved by upstream receptor tyrosine over activity, by mutational activation of PI3K, or inactivation of PTEN (CAMPBELL et ...
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Quercetin Protects against Okadaic Acid-Induced Injury via MAPK and PI3K/Akt/GSK3β Signaling Pathways in HT22 Hippocampal Neurons.
... that PI3K/Akt/Bad/Bcl signaling pathway involved in Aβ-induced neuronal apo- ptosis in rat cortex ...by PI3K/Akt signaling pathway ...via PI3K/Akt/GSK3β ...
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PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia.
... the PI3K/Akt signaling pathway in our ...the PI3K/Akt signaling pathway, which is consistent with our previous reports in acute leukemia ...PTEN, PI3K/Akt pathway, ...
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Dexmedetomidine reduces isoflurane-induced neuroapoptosis partly by preserving PI3K/Akt pathway in the hippocampus of neonatal rats.
... of Akt activity and Bcl-xL/Bad ratio, which may contribute to the increased stabilization of the inner mitochondrial membrane and inhibiting neuroapoptosis provoked by ...the PI3K inhibitor LY294002 in the ...
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Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells.
... ROS signaling is involved in breast carcinogenesis is not clear? While higher doses of ROS induce oxidative damage in the genome of cells leading to cell apoptosis, exposure of low levels of ROS produce genomic ...
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ESTUDO DA VIA DE SINALIZAÇÃO PI3K-Akt E GSK3β EM CARCINOMAS EPIDERMOIDES METASTÁTICOS E NÃO METASTÁTICOS DE CAVIDADE BUCAL
... Furthermore, AKT total, pAKT1-Thr308, pAKT-Ser473, GSK3 β and pGSK3β- Ser9 expression were related to the clinic-pathologic factors, including sex, family cancer history, localization, histological grade and ...
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Roles of PI3K/Akt and c-Jun signaling pathways in human papillomavirus type 16 oncoprotein-induced HIF-1α, VEGF, and IL-8 expression and in vitro angiogenesis in non-small cell lung cancer cells.
... via PI3K/Akt signaling pathway in human cervical cancer cells ...of PI3K/Akt signaling pathway in NSCLC ...activated PI3K/Akt signaling Figure ...
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βig-h3 promotes human osteosarcoma cells metastasis by interacting with integrin α2β1 and activating PI3K signaling pathway.
... that PI3K/AKT signaling pathway is involved in big-h3-induced human osteosarcoma cells metastasis ...a2b1-mediated PI3K/AKT signal ...
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A dual-color fluorescence-based platform to identify selective inhibitors of Akt signaling.
... activated Akt signaling and that spare control cells, we have combined the use of co-cultured isogenic cell lines with fluorescent ...of Akt which constitutively localizes to the plasma membrane, ...
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The role and therapeutic potencial of regulators and effectors of PI3K/Akt pathway in T-cell leukemia
... A via de sinalização Notch está implicada em eventos como diferenciação, proliferação e apoptose, sendo fundamental durante a embriogénese. Existem diversos receptores Notch e também diversos ligandos. Canonicamente, ...
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PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.
... of Akt in animal models [44] and other human organs ...TGFb-induced Akt pathway in myofibroblast differentiation ...TGFb-induced PI3K-Akt pathway involving ...
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Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics
... the PI3K/Akt/mTOR pathway are can- cer-associated events that may hold potential for patient stratification and guided ...of Akt (pAkt), mTOR (pmTOR), S6 (pS6) and PTEN, related with the activation ...
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