Post-translational modifications
Identification and characterization of HTLV-1 HBZ post-translational modifications.
... by post-translational modifications (PTMs) that affect specific signaling pathways important for disease ...seven modifications of HBZ for the first ...
10
Post-translational modifications modulate ligand recognition by the third PDZ domain of the MAGUK protein PSD-95.
... and post-translational modifications, the latter of which is the most efficient method of accelerating cellular responses to environmental changes in ...succinimidation ...
11
Asymmetric post-translational modifications regulate the intracellular distribution of unstimulated STAT3 dimers
... Asymmetric post-translational modifications change the intracellular distribution of STAT3 homodimers more strikingly than symmetric ...by post- translational modifications ...
58
Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.
... and modifications are more likely to occur on the surface of the protein, then their coincidental location on the protein alone might explain the significant relationship we ...and modifications that cannot ...
14
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications.
... The global problem of microbial resistance to antibiotics has resulted in an urgent need to develop new antimicrobial agents. Natural antimicrobial peptides are considered promising candidates for drug development. ...
25
Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response.
... Causes of lower induction of Hsp70 in neurons during heat shock are still a matter of de- bate. To further inquire into the mechanisms regulating Hsp70 expression in neurons, we studied the activity of Heat Shock Factor ...
16
Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output.
... For the redundant repressor protein Dig1, we utilized a sensitized genetic background in which CFP-tagged Ste12 requires Dig1 for its full activity to increase the likelihood of revealing functional roles for Dig1 ...
11
Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A review
... these modifications, as well as their biological significance in the parasite life cycle and their interactions with its vertebrate and invertebrate hosts remains to be ...
8
Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations.
... E . coli giant spheroplasts were generated and used in patch-clamp experiments as described previously [13]. Excised, inside-out patches were examined at room temperature under sym- metrical conditions using a buffer ...
23
Cloning and Functional Assessment of the Recombinant Human Hepcidin-25 in the Baculovirus Expression System
... production. Post-translational modifications such as glycosylation, acylation, amidation, carboxymethylation, and phosphorylation in BES are similar to those found in mammalian cells (Patterson et ...
6
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.
... various post-translational modifications, occurs predominantly during hypoxic conditions [8], which influences stability of HIF-1α and its transcriptional activity ...
25
Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms
... by post-transcriptional and post-translational modifications (PTM), which may differ between non-neoplastic and neoplastic ...several modifications such as N-glycosylation, N-Glycation, ...
10
The role of the small GTPase Saci_1563 in archaellum regulation
... mings. Maracci, Cristina, and Marina V. ‘Review: Translational GTPases: Translational GTPases’. ‘Isolation and Characterization of a Dominant Negative Mutant of Bacillus Subtilis GTP-Bi[r] ...
102
Epigenetic Modifications: Therapeutic Potential in Cancer
... histone modifications is another hallmark of ...histone modifications can be deregulated by over- expression, mutations and/or chromosomal translocations of any of the histone acetylation/deacetyaltion ...
14
Rev. Bras. Psiquiatr. vol.34 número1
... Employment: University of Alberta, Alberta Hospital Edmonton, Canada; INCT-TM (National Institute for Translational Medicine). Glen Baker[r] ...
2
Translational control in plant antiviral immunity
... sion of global in vivo translation and decreased loading of host mRNA in actively translating polysomes (PS) frac- tions. Likewise, induction of T474D expression through a dexamethasone-inducible promoter also impairs ...
13
Microwave oven modifications for laboratory applications.
... MICROWAVE OVEN MODIFICATIONS FOR LABORATORY APPLICATIONS. Domestic mi- crowave oven was modified for laboratory applications. Electronic system was made for control- ling magnetron irradiation time. Exhaustion and ...
4
miRNA-dependent translational repression in the Drosophila ovary.
... miRNA-dependent translational repression at the level of initiation, it does leave open the possibility that action of miRNAs after initiation of translation may be more prominent in this setting than in cells ...
9
Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells.
... We then confronted these functional data with the quantification of CFTR protein amount: N-WASP depletion resulted in only a small decrease, while Cdc42 indeed elicited a 37% in- crease of total CFTR amount (Fig. 8A and ...
23
Arthropod Vectors and Disease Transmission: Translational Aspects.
... Environmental modifications such as the draining of swamps are not feasible everywhere and are extremely costly, in addition to having potentially devastating effects on the ...
11