Protease-activated receptor (PAR)-2
Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells.
... Protease-Activated Receptor-2 (PAR2) has been implicated through genetic knockout mice with cytokine regulation and arthritis ...endogenous protease that activates PAR2) and a PAR2 ...
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Protease-activated receptor 2 mediates mucus secretion in the airway submucosal gland.
... This study was approved by the Committee on Animal Research at Yonsei Medical Center, and all experiments with animals were performed under appropriate guidelines. Pig tracheas were harvested from 18 juvenile Yorkshire ...
8
Granzyme K activates protease-activated receptor-1.
... Because fibroblasts are a major component of connective tissues and fibroblasts proliferation is an important process in wound healing, we examined the functional consequences of GrK- induced signaling on fibroblast ...
9
Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.
... for receptor binding, we next investigated the ability of KLK1 in the activation of PAR-4 using calcium mobilization ...KLK1 activated PAR-4 and desensitized it from the subsequent agonist ...
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Participação da tripsina e do receptor ativado por protease (PAR)-4 no recrutamento de neutrófilos em modelo de pleurisia experimental
... As serinoproteases agem através da clivagem do grupamento amino terminal de receptores acoplados à proteína G denominados PAR (proteinase activated receptors, PARs). Após clivagem, a porção restante de aminoácidos ...
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Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1).
... Cancers that spread (metastasize) from their original site to another area of the body, are called metastatic cancers. metastatic cancers have poor prognosis and high mortality [1]. A full understanding of the biological ...
10
Estudo do papel do receptor ativado por protease (PAR)-2 no recrutamento de eosinófilos induzido por triptase em modelo de pleurisia em camundongos
... (proteinase-activated receptor, PAR) fazem parte de uma família de receptores acoplados à proteína G que são ativados por serino-proteases através da clivagem proteolítica de uma sequência específica de ...
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Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma
... (USA) and antibodies against PAR-1 were from Santa Cruz Biotechnology (USA) (#sc-13503; 1:10). All sections were subjected to heat-induced epitope retrieval in citrate buf- fer, pH 6.0, for 3 min, followed by inhibition ...
7
Increased expression of protease-activated receptor 4 and Trefoil factor 2 in human colorectal cancer.
... Human colorectal cancer cell lines LoVo and HT-29 were from the American Type Culture Collection (Manassas, VA, USA). The LoVo cells overexpressing PAR4 (LoVo-PAR4) and the cells transfected with a mock plasmid ...
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A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity
... nyl fluoride, and 1% NP-40) containing a protease inhibitor cocktail (Sigma). Whole-cell lysates were incubated on ice for 30 minutes and then cleared at 13,000 rpm for 20 minutes at 4°C. The immune complexes were ...
10
Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.
... Synthesized cDNA was used for real-time PCR with specific primer sequences for the pro-inflammatory cytokines, IL-1b (Fwd: 5 9-CAC CTC TCA AGC AGA GCA CAG-39, Rev: 59-GGG TTC CAT GGT GAA GTC AAC-3 9) and TNFa (Fwd: ...
14
Effects of a PPARG gene variant on obesity characteristics in Brazil
... Since PPARγ plays a key role in adipo- genesis and lipogenesis and treatment with PPARγ-agonists alters plasma lipid profiles (14-16), the possible association between the Pro12Ala polymorphism and plasma li- pid levels ...
6
Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors
... In some cases, viral infections can cause inhibition of host protein synthesis whilst in other cases a virus- induced differential expression of host proteins has been found. ECwt infection of villus cells induced the ...
15
Regulation of Adipocyte Differentiation via MicroRNAs
... 2 stem cells expresses and secretes BMP-4 at the same time point when exogenous BMP-4 is added to C3H10T1/2 cells for adipogenic differentiation. Furthermore, exposure of A33 cells to noggin, a naturally ...
14
Arq Bras Endocrinol Metab vol.57 número8
... leptin receptor (LEPR), adiponectin (APM1), peroxisome proliferator-activated receptor gamma (PPARG) and uncoupling protein 1 – with anthropometric, metabolic, and dietary parameters in a Southern ...
9
Different feeding habits influence the activity of digestive enzymes in freshwater fish
... ABSTRACT: The aim of this study was to verify the activity of some digestive enzymes in four fish species with different feeding habits. Knowledge of these enzymatic activities can help us to understand the species’ ...
7
ReFlexIn: a flexible receptor protein-ligand docking scheme evaluated on HIV-1 protease.
... the receptor structure, in the present case, along the series of different bound HIV-1 protease ...the receptor conformation variable lambda indicates into which bound structure (or intermediate ...
13
Eclet. Quím. vol.31 número4
... the activated carbon depends on the surface characteristics, such as surface area, pore structure and surface acidity and solutions ...the activated carbons show surface areas of about 560 m 2 g -1 , ...
7
Caracterização bioquímica e molecular da hipercolesterolemia familiar na Região Norte e Centro de Portugal
... Esta mutação é conhecida por ter uma ampla distribuição geográfica na Europa apresentando desiguais distribuições. Actualmente, a percentagem de mutações no gene APOB identificadas em Portugal é de 2% [54] muito ...
104
Estudos sobre a interação parasito-hospedeiro: papel das amastinas de Trypanosoma cruzi
... cada receptor é conferida pela cadeia , a qual apresenta características distintas entre os receptores de IL-2 e ...do receptor de ambas citocinas são estruturalmente similares, pois ambos são ...
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