Protective role
Sulfasalazine-induced renal and hepatic injury in rats and the protective role of taurine
... a protective role in sulfasalazine‑induced renal and liver injury prob‑ ably by attenuating oxidative stress and its consequences in these ...of protective properties of taurine against sulfasala‑ ...
6
A localized PCR inhibitor in a porcelain crab suggests a protective role
... In this study, we report the presence of a yet-unknown inhibitory molecule that is local- ized in the foregut of the porcelain crab Petrolisthes rufescens (Anomura: Porcellanidae). This species is a filter feeder ...
19
Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction.
... Interestingly, we found that the DOX-treated SMP30 KO mice showed depressed left ventricular systolic function compared with the DOX-treated WT mice, suggesting the absence of SMP30 caused more progressive cardiac ...
8
Lead Nitrate Induced Testicular Toxicity in Diabetic and Non-Diabetic Rats: Protective Role of Sodium Selenite
... In the present study, even though lead nitrate was given orally at low dose to diabetic and non- diabetic rats, histopathological and enzymatic changes were observed in the rat testis tissues, but none of the rats died ...
7
Biological evidence of the protective role of regucalcin in breast cancer
... regulation of multiple intracellular signaling pathways such as cell proliferation, apoptosis and metabolism. RGN also has been identified as a hormonally regulated gene, which includes the sex steroids androgens. ...
145
Does the eosinophil have a protective role in amebiasis?
... philia in gerbils (M. unguiculatus) through four injections of an innocuous Toxocara canis antigen, prior to the induction of experimental AAL with 1 x 10 5 intraportally injected ameba trophozoites (Velázquez et al. ...
4
Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity
... Various studies suggest that the irreversible glycation of the cytoskeletal proteins in axons of peripheral nerves is responsible for the formation of cross-links and for the occurrence of functional alterations in ...
13
Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine
... β-naphtoflavone induces different CYP enzymes, mainly CYP1A family. 24 Phenobarbital causes different type of CYP enzyme induction such as CYP 2C9 and 1AC. 25 Since a wide range of metabolic enzymes are induced by these ...
8
The protective role of transcription factor NRF2 against liver injury in human and mouse models of Hereditary Hemochromatosis
... The liver is capable of accumulating high amounts of iron. The excess free iron leads to liver damage due to ROS formation. NRF2 upregulates many cytoprotective enzymes that take part in the antioxidant response and ...
99
Copper-induced changes of lipid peroxidation and hemato-biochemical parameters in rat blood: Protective role of flavonoids
... showed protective efects on hematological ...the protective efects of Qe and ec are likely due to their ability to capture ROS and thereby prevent erythrocyte damage and ...
10
The protective role of sulfated polysaccharides from green seaweed Udotea flabellum in cells exposed to oxidative damage
... Abstract: Seaweed is a rich source of bioactive sulfated polysaccharides. We obtained six sulfated polysaccharide-rich fractions (UF-0.3, UF-0.5, UF-0.6, UF-0.7, UF-1.0, and UF-2.0) from the green seaweed Udotea ...
16
Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin.
... crucial role of melatonin in the prevention of oxidative mitochondrial damage due to its direct influence on free radical removal, cardiolipin peroxidation and cytochrome c release from mitochondria ...
8
Influence of normal mammary epithelium on breast cancer progression: the protective role of early pregnancy
... the role of cell differentiation, which is maintained after involution, and hypothesizes that luminal cells may have a decreased ability to proliferate, hence becoming less susceptible to carcinogenic stimuli 11 ...
5
Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice.
... Funding: This work was supported by an Action de Recherche Concerte´e of the Communaute´ Franc¸aise de Belgique, an Interuniversity Attraction Pole grant from the Politique Scientifique Fe´de´rale (IAP-P6/30), Prime ...
6
Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient
... This prompted our interest to investigate the protective effects of a standardized aqueous extract from fruiting bodies of H. erinaceus (HESAE) against oxidative damage induced by L-Buthionine sulfoximine (BSD) in ...
9
Human leukocyte antigens and systemic lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03.
... Genotyping of HLA-DRB1 and DQB1 was performed by a polymerase chain reaction technique using sequence-specific oligonucleotide probes (WAKFlow HLA typing kits, Wakunaga, Hiroshima, Japan), using a Bio-Plex 200 system ...
7
The protective role of adiponectin for lipoproteins in end-stage renal disease patients: relationship with diabetes and body mass index
... less protective CVD risk profile, with significantly lower HDLc, % of large HDL, and adiponectin and signifi- cantly higher (%) small HDLc subfractions and ...
12
Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients.
... relevant role of IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714 in the development of several inflammatory conditions such as IBD and ankylosing spondylitis has been proposed ...
8
Hypericum perforatum phenolic compounds : protective role in the toxicity induced by heterologous expression of α-synuclein and huntingtin in yeast cells
... In fact, the brain is inclined to ROS production and oxidative stress due to its elevated metabolic rate, combined with the content of oxidizable molecules, such as dopamine and neuromelanin, whose metabolism generates ...
64
Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.
... Considering that RAGE signaling results in sustained cellular activation we were interested to study the role of RAGE in lung inflammation during Klebsiella pneumonia. Thus, we analyzed lung tissue slides obtained ...
15