Protein dynamics
Protein dynamics in individual human cells: experiment and theory.
... the dynamics of protein circuits in living human ...the dynamics and variability of a protein over time? Here, we address this experimentally and theoretically, by means of accurate ...
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Protein dynamics: hydration and cavities
... Previous study by our group has shown that insulin fibrils are also stable to pressures of at least 1.2 GPa (54). Foguel and co- workers (55), on the other hand, found that amyloid fibrils of full-length TTR and α- ...
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Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.
... Hsa21 protein coding genes and 5 microRNA genes ...50 protein coding genes that are not ortho- logs of Hsa21 genes ...Hsa21 protein coding genes and being trisomic for a substantial set of irrelevant ...
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Protein dynamics governed by interfaces of high polarity and low packing density.
... A third common type of equilibrium intermediates is that found in chemical unfolding. The role of LIPs in chemical intermediates can be exemplified by the equilibrium intermediate accumulating in the urea unfolding of ...
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Is protein folding sub-diffusive?
... folding dynamics is often described as diffusion on a free energy surface considered as a function of one or few reaction ...coordinate, protein dynamics is ...the dynamics is ...diffusive ...
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Comparison of the Internal Dynamics of Metalloproteases Provides New Insights on Their Function and Evolution
... of protein internal dynamics and its role in enzyme function, we are interested in assessing how the structural heterogeneity of metallopro- teases translates into their ...type protein thermolysin, ...
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Mixed quantum-classical dynamics of an amide-I vibrational excitation in a protein a-helix
... the protein, resulting in pro- tein activation or ...in protein dynamics, but also isolated vibrations have extremely short lifetimes of on the order of 10 −13 ...
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Atomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer.
... tant protein hydrophobicity relative to the wt protein could profoundly affect the stiochio- chemistry of hydrogen bond formation between the enzyme and DNA, as is evident from S5 ...
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Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules.
... 21–24) induced SG, in which dFMRP co-localizes with the canonical SG markers deIF4E (Fig. 1C; panels 8 and 12), dPABP (Fig. 1C; panels 20 and 24 ), GFP-eIF4A and with poly(A)+mRNA (Fig. S1; panel 8 and data not shown). ...
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Membrane topology and cellular dynamics of foot-and-mouth disease virus 3A protein.
... truncated protein lacking the N-terminal region of 3A (DN-ter), and iv) truncated proteins lacking the C-terminal region and maintaining (DC-ter) or not (DHR-C-ter) the ...
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Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.
... actin-binding protein that regulates the actin cytoskeleton through diverse mechanisms ...actin dynamics through its barbed-end capping and bundling activities ...actin dynamics and ...
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Model for the peptide-free conformation of class II MHC proteins.
... molecular dynamics models for the peptide- free ...molecular dynamics may provide a useful model for the peptide-free conformation, none of the available conformational probes directly addresses the key ...
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Changes in protein interaction networks between normal and cancer conditions: Total chaos or ordered disorder?
... molecules. Here the interactions were considered among the 722 signaling proteins, other predicted interacting proteins were excluded. Thus 609 proteins were found to show total 8359 possible interactions among them. ...
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Concerted spatio-temporal dynamics of imported DNA and ComE DNA uptake protein during gonococcal transformation.
... membrane is not the only bottleneck for transformation and the accumulation of DNA in the periplasm is not likely to be caused by pilV deletion. Our experiments show that the gonococcal periplasm is saturable with DNA ...
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microRNA as a potential vector for the propagation of robustness in protein expression and oscillatory dynamics within a ceRNA network.
... the protein level is small (below the threshold needed to generate of cellular response) (see ...the protein level is above the threshold with high levels of TF ...RNA, protein and miRNA are shown in ...
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Predicting protein phenotypes based on protein-protein interaction network.
... Because of the complexity of phenotype research, we selected the budding yeast Saccharomyces cerevisiae (a well studied model organism [25,26]) as a model system. The protein data used here was taken from CYGD ...
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Heterochromatin dynamics.
... Asdiscussedbytheauthorsofboth studies,severalimportantconclusions canbedrawn.Instrikingcontrastto previousmodels,HP1appearstobea verymobilemolecule.Theformat[r] ...
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Composition of Overlapping Protein-Protein and Protein-Ligand Interfaces.
... of protein interfaces to those of overlapping pro- tein-ligand interfaces should aid in targeting protein-protein interaction ...for protein interfaces and ...
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Reverse-engineering post-transcriptional regulation of gap genes in Drosophila melanogaster.
... We have created a quantitative mRNA expression dataset with high spatial and temporal resolution for the trunk gap genes Kru¨ppel (Kr), knirps (kni) and giant (gt), which spans the entire duration of the blastoderm stage ...
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Labor Earnings Dynamics in Post-Stabilization Brazil
... After the covariance structure of the log of real weekly wages is estimated and the variance of the log of real weekly wages is decomposed into its permanent and transitory components, w[r] ...
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